메뉴 건너뛰기




Volumn 17, Issue 33, 2011, Pages 3802-3809

Rebamipide promotes healing of colonic ulceration through enhanced epithelial restitution

Author keywords

Experimental colitis; Extracellular signal regulated kinase; Intestinal epithelial cells; Rebamipide; Rho kinase

Indexed keywords

ENEMA; MITOGEN ACTIVATED PROTEIN KINASE; REBAMIPIDE; RHO KINASE; TRINITROBENZENESULFONIC ACID;

EID: 80053896854     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i33.3802     Document Type: Article
Times cited : (27)

References (44)
  • 1
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007; 448: 427-434
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 2
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998; 115: 182-205
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 3
    • 0032875139 scopus 로고    scopus 로고
    • Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: The best offense is a good defense
    • Podolsky DK. Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense. Am J Physiol 1999; 277: G495-G499
    • (1999) Am J Physiol , vol.277
    • Podolsky, D.K.1
  • 4
    • 25644456042 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of the epithelial repair in IBD
    • Okamoto R, Watanabe M. Cellular and molecular mechanisms of the epithelial repair in IBD. Dig Dis Sci 2005; 50 Suppl 1: S34-S38
    • (2005) Dig Dis Sci , vol.50 , Issue.SUPPL. 1
    • Okamoto, R.1    Watanabe, M.2
  • 5
    • 10844272960 scopus 로고    scopus 로고
    • Small therapeutic molecules for the treatment of inflammatory bowel disease
    • van Deventer SJ. Small therapeutic molecules for the treatment of inflammatory bowel disease. Gut 2002; 50 Suppl 3: III47-III53
    • (2002) Gut , vol.50 , Issue.SUPPL. 3
    • van Deventer, S.J.1
  • 6
    • 77953282758 scopus 로고    scopus 로고
    • Rebamipide: A gastrointestinal protective drug with pleiotropic activities
    • Naito Y, Yoshikawa T. Rebamipide: a gastrointestinal protective drug with pleiotropic activities. Expert Rev Gastroen-terol Hepatol 2010; 4: 261-270
    • (2010) Expert Rev Gastroen-terol Hepatol , vol.4 , pp. 261-270
    • Naito, Y.1    Yoshikawa, T.2
  • 7
    • 70449487657 scopus 로고    scopus 로고
    • Diagnostic and treatment algorithms of ul-cerative colitis in Ukraine
    • Skrypnyk IN. Diagnostic and treatment algorithms of ul-cerative colitis in Ukraine. Dig Dis 2009; 27: 550-554
    • (2009) Dig Dis , vol.27 , pp. 550-554
    • Skrypnyk, I.N.1
  • 8
    • 0033915609 scopus 로고    scopus 로고
    • Anti-inflammatory effect of rebamipide enema on proctitis type ulcerative colitis: A novel therapeutic alternative
    • Makiyama K, Takeshima F, Kawasaki H, Zea-Iriarte WL. Anti-inflammatory effect of rebamipide enema on proctitis type ulcerative colitis: a novel therapeutic alternative. Am J Gastroenterol 2000; 95: 1838-1839
    • (2000) Am J Gastroenterol , vol.95 , pp. 1838-1839
    • Makiyama, K.1    Takeshima, F.2    Kawasaki, H.3    Zea-Iriarte, W.L.4
  • 9
    • 30844471588 scopus 로고    scopus 로고
    • Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: A prospective study report
    • Makiyama K, Takeshima F, Hamamoto T. Efficacy of rebamipide enemas in active distal ulcerative colitis and proctitis: a prospective study report. Dig Dis Sci 2005; 50: 2323-2329
    • (2005) Dig Dis Sci , vol.50 , pp. 2323-2329
    • Makiyama, K.1    Takeshima, F.2    Hamamoto, T.3
  • 10
    • 25644451201 scopus 로고    scopus 로고
    • Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis
    • Miyata M, Kasugai K, Ishikawa T, Kakumu S, Onishi M, Mori T. Rebamipide enemas-new effective treatment for patients with corticosteroid dependent or resistant ulcerative colitis. Dig Dis Sci 2005; 50 Suppl 1: S119-S123
    • (2005) Dig Dis Sci , vol.50 , Issue.SUPPL. 1
    • Miyata, M.1    Kasugai, K.2    Ishikawa, T.3    Kakumu, S.4    Onishi, M.5    Mori, T.6
  • 11
    • 53449085492 scopus 로고    scopus 로고
    • Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: Open label study
    • Matsumoto S, Tsuji K, Shirahama S. Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers: open label study. World J Gastroenterol 2008; 14: 4059-4064
    • (2008) World J Gastroenterol , vol.14 , pp. 4059-4064
    • Matsumoto, S.1    Tsuji, K.2    Shirahama, S.3
  • 12
    • 0033902814 scopus 로고    scopus 로고
    • Intestinal restitution: Progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing
    • Lotz MM, Rabinovitz I, Mercurio AM. Intestinal restitution: progression of actin cytoskeleton rearrangements and inte-grin function in a model of epithelial wound healing. Am J Pathol 2000; 156: 985-996
    • (2000) Am J Pathol , vol.156 , pp. 985-996
    • Lotz, M.M.1    Rabinovitz, I.2    Mercurio, A.M.3
  • 15
    • 9844228499 scopus 로고    scopus 로고
    • Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis
    • Ameho CK, Adjei AA, Harrison EK, Takeshita K, Morioka T, Arakaki Y, Ito E, Suzuki I, Kulkarni AD, Kawajiri A, Yamamoto S. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis. Gut 1997; 41: 487-493
    • (1997) Gut , vol.41 , pp. 487-493
    • Ameho, C.K.1    Adjei, A.A.2    Harrison, E.K.3    Takeshita, K.4    Morioka, T.5    Arakaki, Y.6    Ito, E.7    Suzuki, I.8    Kulkarni, A.D.9    Kawajiri, A.10    Yamamoto, S.11
  • 16
    • 0034610997 scopus 로고    scopus 로고
    • Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells
    • Petit V, Boyer B, Lentz D, Turner CE, Thiery JP, Vallés AM. Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol 2000; 148: 957-970
    • (2000) J Cell Biol , vol.148 , pp. 957-970
    • Petit, V.1    Boyer, B.2    Lentz, D.3    Turner, C.E.4    Thiery, J.P.5    Vallés, A.M.6
  • 17
    • 0028898281 scopus 로고
    • Disruption of colonic electrolyte transport in experimental colitis
    • Bell CJ, Gall DG, Wallace JL. Disruption of colonic electrolyte transport in experimental colitis. Am J Physiol 1995; 268: G622-G630
    • (1995) Am J Physiol , vol.268
    • Bell, C.J.1    Gall, D.G.2    Wallace, J.L.3
  • 19
    • 25644442415 scopus 로고    scopus 로고
    • Direct autoradio-graphic evidence that rebamipide interacts with neutrophils in dextran sulfate sodium induced colitis in rats
    • Nakamura M, Takahashi T, Matsumoto T, Atsuda K, Hibi N, Matsui H, Yamada H, Tsuchimoto K. Direct autoradio-graphic evidence that rebamipide interacts with neutrophils in dextran sulfate sodium induced colitis in rats. Dig Dis Sci 2005; 50 Suppl 1: S113-S118
    • (2005) Dig Dis Sci , vol.50 , Issue.SUPPL. 1
    • Nakamura, M.1    Takahashi, T.2    Matsumoto, T.3    Atsuda, K.4    Hibi, N.5    Matsui, H.6    Yamada, H.7    Tsuchimoto, K.8
  • 20
    • 17144371877 scopus 로고    scopus 로고
    • Protective effect of intra-rectal administration of rebamipide on dextran sulfate sodium-induced rat colitis
    • Okayama M, Tsubouchi R, Nishio H, Kato S, Takeuchi K. Protective effect of intra-rectal administration of rebamipide on dextran sulfate sodium-induced rat colitis. Digestion 2004; 70: 240-249
    • (2004) Digestion , vol.70 , pp. 240-249
    • Okayama, M.1    Tsubouchi, R.2    Nishio, H.3    Kato, S.4    Takeuchi, K.5
  • 21
    • 0041355284 scopus 로고    scopus 로고
    • Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet' s disease: A randomised, double-blind, placebo-controlled study
    • Matsuda T, Ohno S, Hirohata S, Miyanaga Y, Ujihara H, In-aba G, Nakamura S, Tanaka S, Kogure M, Mizushima Y. Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet' s disease: a randomised, double-blind, placebo-controlled study. Drugs R D 2003; 4: 19-28
    • (2003) Drugs R D , vol.4 , pp. 19-28
    • Matsuda, T.1    Ohno, S.2    Hirohata, S.3    Miyanaga, Y.4    Ujihara, H.5    In-Aba, G.6    Nakamura, S.7    Tanaka, S.8    Kogure, M.9    Mizushima, Y.10
  • 22
    • 0035742787 scopus 로고    scopus 로고
    • The inhibitory mechanism of re-bamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions
    • Ro JY, Kim JY, Kim KH. The inhibitory mechanism of re-bamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. Pharmacology 2001; 63: 175-184
    • (2001) Pharmacology , vol.63 , pp. 175-184
    • Ro, J.Y.1    Kim, J.Y.2    Kim, K.H.3
  • 23
    • 0033840088 scopus 로고    scopus 로고
    • The effect of re-bamipide on cisplatin-induced nephrotoxicity in rats
    • Saad SY, Najjar TA, Al-Sohaibani MO. The effect of re-bamipide on cisplatin-induced nephrotoxicity in rats. Pharmacol Res 2000; 42: 81-86
    • (2000) Pharmacol Res , vol.42 , pp. 81-86
    • Saad, S.Y.1    Najjar, T.A.2    Al-Sohaibani, M.O.3
  • 24
    • 0031667687 scopus 로고    scopus 로고
    • Effect of rebamipide on liver damage and increased tumor necrosis factor in a rat model of endotoxin shock
    • Hong KW, Kim KE, Rhim BY, Lee WS, Kim CD. Effect of rebamipide on liver damage and increased tumor necrosis factor in a rat model of endotoxin shock. Dig Dis Sci 1998; 43: 154S-159S
    • (1998) Dig Dis Sci , vol.43
    • Hong, K.W.1    Kim, K.E.2    Rhim, B.Y.3    Lee, W.S.4    Kim, C.D.5
  • 25
    • 0029587399 scopus 로고
    • Rebamipide ameliorates hepatic dysfunction induced by ischemia/reperfusion in rats
    • Lee SM, Kim KH. Rebamipide ameliorates hepatic dysfunction induced by ischemia/reperfusion in rats. Eur J Pharmacol 1995; 294: 41-46
    • (1995) Eur J Pharmacol , vol.294 , pp. 41-46
    • Lee, S.M.1    Kim, K.H.2
  • 27
    • 33746673364 scopus 로고    scopus 로고
    • OPC-12759 increases proliferation of cultured rat conjuncti-val goblet cells
    • Ríos JD, Shatos M, Urashima H, Tran H, Dartt DA. OPC-12759 increases proliferation of cultured rat conjuncti-val goblet cells. Cornea 2006; 25: 573-581
    • (2006) Cornea , vol.25 , pp. 573-581
    • Ríos, J.D.1    Shatos, M.2    Urashima, H.3    Tran, H.4    Dartt, D.A.5
  • 28
    • 3342957097 scopus 로고    scopus 로고
    • Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treat-ed in vivo model
    • Urashima H, Okamoto T, Takeji Y, Shinohara H, Fujisawa S. Rebamipide increases the amount of mucin-like substances on the conjunctiva and cornea in the N-acetylcysteine-treat-ed in vivo model. Cornea 2004; 23: 613-619
    • (2004) Cornea , vol.23 , pp. 613-619
    • Urashima, H.1    Okamoto, T.2    Takeji, Y.3    Shinohara, H.4    Fujisawa, S.5
  • 29
    • 0037900711 scopus 로고    scopus 로고
    • Cy-toprotective effects of rebamipide and carteolol hydrochlo-ride against ultraviolet B-induced corneal damage in mice
    • Tanito M, Takanashi T, Kaidzu S, Yoshida Y, Ohira A. Cy-toprotective effects of rebamipide and carteolol hydrochlo-ride against ultraviolet B-induced corneal damage in mice. Invest Ophthalmol Vis Sci 2003; 44: 2980-2985
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 2980-2985
    • Tanito, M.1    Takanashi, T.2    Kaidzu, S.3    Yoshida, Y.4    Ohira, A.5
  • 30
    • 0031695095 scopus 로고    scopus 로고
    • Protection by rebamipide against acetic acid-induced colitis in rats: Relationship with its antioxidative activity
    • Sakurai K, Osaka T, Yamasaki K. Protection by rebamipide against acetic acid-induced colitis in rats: relationship with its antioxidative activity. Dig Dis Sci 1998; 43: 125S-133S
    • (1998) Dig Dis Sci , vol.43
    • Sakurai, K.1    Osaka, T.2    Yamasaki, K.3
  • 31
    • 0031669038 scopus 로고    scopus 로고
    • Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short- and long-term administration of rebamipide
    • Iwai A, Iwashita E. Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short- and long-term administration of rebamipide. Dig Dis Sci 1998; 43: 143S-147S
    • (1998) Dig Dis Sci , vol.43
    • Iwai, A.1    Iwashita, E.2
  • 32
    • 0033831051 scopus 로고    scopus 로고
    • Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats
    • Kishimoto S, Haruma K, Tari A, Sakurai K, Nakano M, Nakagawa Y. Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats. Dig Dis Sci 2000; 45: 1608-1616
    • (2000) Dig Dis Sci , vol.45 , pp. 1608-1616
    • Kishimoto, S.1    Haruma, K.2    Tari, A.3    Sakurai, K.4    Nakano, M.5    Nakagawa, Y.6
  • 33
    • 25644432759 scopus 로고    scopus 로고
    • Rebamipide enema is effective for treatment of experimental dextran sulfate sodium induced colitis in rats
    • Nakashima T, Maeda T, Nagamoto H, Kumakura T, Takai M, Mori T. Rebamipide enema is effective for treatment of experimental dextran sulfate sodium induced colitis in rats. Dig Dis Sci 2005; 50 Suppl 1: S124-S131
    • (2005) Dig Dis Sci , vol.50 , Issue.SUPPL. 1
    • Nakashima, T.1    Maeda, T.2    Nagamoto, H.3    Kumakura, T.4    Takai, M.5    Mori, T.6
  • 34
    • 0242684448 scopus 로고    scopus 로고
    • Gastric restitution is inhibited by dexametha-sone, which is reversed by hepatocyte growth factor and re-bamipide
    • Takahashi M, Takada H, Takagi K, Kataoka S, Soma R, Ku-wayama H. Gastric restitution is inhibited by dexametha-sone, which is reversed by hepatocyte growth factor and re-bamipide. Aliment Pharmacol Ther 2003; 18 Suppl 1: 126-132
    • (2003) Aliment Pharmacol Ther , vol.18 , Issue.SUPPL. 1 , pp. 126-132
    • Takahashi, M.1    Takada, H.2    Takagi, K.3    Kataoka, S.4    Soma, R.5    Ku-Wayama, H.6
  • 35
    • 0041837509 scopus 로고    scopus 로고
    • Trefoil factors: Initiators of muco-sal healing
    • Taupin D, Podolsky DK. Trefoil factors: initiators of muco-sal healing. Nat Rev Mol Cell Biol 2003; 4: 721-732
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 721-732
    • Taupin, D.1    Podolsky, D.K.2
  • 36
    • 0034030123 scopus 로고    scopus 로고
    • Peptide gene expression in gastrointestinal mucosal ulceration: Ordered sequence or redundancy?
    • Wong WM, Playford RJ, Wright NA. Peptide gene expression in gastrointestinal mucosal ulceration: ordered sequence or redundancy? Gut 2000; 46: 286-292
    • (2000) Gut , vol.46 , pp. 286-292
    • Wong, W.M.1    Playford, R.J.2    Wright, N.A.3
  • 37
    • 40949121441 scopus 로고    scopus 로고
    • Transcrip-tional profling defnes the roles of ERK and p38 kinases in epidermal keratinocytes
    • Gazel A, Nijhawan RI, Walsh R, Blumenberg M. Transcrip-tional profling defnes the roles of ERK and p38 kinases in epidermal keratinocytes. J Cell Physiol 2008; 215: 292-308
    • (2008) J Cell Physiol , vol.215 , pp. 292-308
    • Gazel, A.1    Nijhawan, R.I.2    Walsh, R.3    Blumenberg, M.4
  • 40
    • 2642585688 scopus 로고    scopus 로고
    • Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions
    • Cetin S, Ford HR, Sysko LR, Agarwal C, Wang J, Neal MD, Baty C, Apodaca G, Hackam DJ. Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions. J Biol Chem 2004; 279: 24592-24600
    • (2004) J Biol Chem , vol.279 , pp. 24592-24600
    • Cetin, S.1    Ford, H.R.2    Sysko, L.R.3    Agarwal, C.4    Wang, J.5    Neal, M.D.6    Baty, C.7    Apodaca, G.8    Hackam, D.J.9
  • 41
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • Hall A. Rho GTPases and the actin cytoskeleton. Science 1998; 279: 509-514
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.