Determination of digoxin clearance in Japanese elderly patients for optimization of drug therapy: A population pharmacokinetics analysis using nonlinear mixed-effects modelling

Drugs and Aging

Volumn 28, Issue 10, 2011, Pages 831-841

  Yukawa, Miho ^a   Yukawa, Eiji ^b   Suematsu, Fumihiro ^c   Takiguchi, Takako ^b   Ikeda, Hirohito ^a   Aki, Hatsumi ^a   Mimemoto, Masao ^d  

^a FUKUOKA UNIVERSITY   (Japan)

^b DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^c Yufuin Kosei Nenkin Hospital   (Japan)

^d KYUSHU KOSEI NENKIN HOSPITAL   (Japan)

Author keywords

Cardiac glycosides; Digoxin; Elderly

Indexed keywords

CREATININE; DIGOXIN; DILTIAZEM; NIFEDIPINE; SPIRONOLACTONE; VERAPAMIL;

AGE; AGED; AGED HOSPITAL PATIENT; ARTICLE; BODY WEIGHT; COMPUTER PROGRAM; CONGESTIVE HEART FAILURE; CREATININE BLOOD LEVEL; DOSE CALCULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REGIMEN; DRUG MONITORING; ELDERLY CARE; FEMALE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; MODEL; NONLINEAR MIXED EFFECT MODELLING; OUTCOME ASSESSMENT; PARAMETER; PATIENT CHARACTERISTIC; PREDICTIVE VALUE; PRIORITY JOURNAL; SEX DIFFERENCE; STEADY STATE; TABLET; THERAPY EFFECT;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; DIGOXIN; FEMALE; HUMANS; MALE; NONLINEAR DYNAMICS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SOFTWARE; USER-COMPUTER INTERFACE;

EID: 80053896844     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11594230-000000000-00000     Document Type: Article

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