Population pharmacokinetic model of digoxin in older Chinese patients and its application in clinical practice

Acta Pharmacologica Sinica

Volumn 31, Issue 6, 2010, Pages 753-758

  Zhou, Xiao Dan ^a,b   Gao, Yan ^a   Guan, Zheng ^c   Li, Zhong Dong ^a   Li, Jun ^b  

^a AIR FORCE GENERAL HOSPITAL   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Aging; Digoxin; NONMEM; Population pharmacokinetics; Retrospective studies

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CREATININE; DIGOXIN; DILTIAZEM; NIFEDIPINE; NITRATE; PROPAFENONE; SPIRONOLACTONE;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHINESE; CLINICAL PRACTICE; CREATININE BLOOD LEVEL; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; FEMALE; HUMAN; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; POPULATION MODEL; RETROSPECTIVE STUDY; UREA NITROGEN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ANTI-ARRHYTHMIA AGENTS; ASIAN CONTINENTAL ANCESTRY GROUP; COMPUTER SIMULATION; DIGOXIN; FEMALE; HEART FAILURE; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MODELS, BIOLOGICAL; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SOFTWARE;

EID: 77953244326     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.51     Document Type: Article

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