Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin

World Journal of Gastroenterology

Volumn 17, Issue 33, 2011, Pages 3836-3841

  Fahim, Mohamed A ^a   Kataya, Hazem ^a   El Kharrag, Rkia ^a   Amer, Dena Am ^a   Al Ramadi, Basel ^a   Karam, Sherif M ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Gastrointestinal cell proliferation; Gastrointestinal mucosal damage; Ghrelin

Indexed keywords

BROXURIDINE; DOXORUBICIN; GHRELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; DUODENUM; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; MOUSE; NONHUMAN; OSMOTIC PUMP; STEM CELL; STOMACH; STOMACH EPITHELIUM; STOMACH PROTECTION; TISSUE REGENERATION; TREATMENT DURATION;

EID: 80053894731     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i33.3836     Document Type: Article

References (31)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kan-gawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660
2. Tomasetto C, Karam SM, Ribieras S, Masson R, Lefèbvre O, Staub A, Alexander G, Chenard MP, Rio MC. Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide. Gastroenterology 2000; 119: 395-405
3. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M. The tissue distribution of the mRNA of ghre-lin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988
4. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Oga-wa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000; 85: 4908-4911
5. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198
6. Camina JP, Carreira MC, Micic D, Pombo M, Kelestimur F, Dieguez C, Casanueva FF. Regulation of ghrelin secretion and action. Endocrine 2003; 22: 5-12
7. Poitras P, Tomasetto C. The potential of ghrelin as a proki-netic. Regul Pept 2009; 155: 24-27
8. Nagaya N, Kangawa K. Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure. Regul Pept 2003; 114: 71-77
9. Xu G, Li Y, An W, Zhang W. Ghrelin and cell differentiation. Acta Biochim Biophys Sin (Shanghai) 2008; 40: 841-847
10. Johansson I, Destefanis S, Aberg ND, Aberg MA, Blomgren K, Zhu C, Ghè C, Granata R, Ghigo E, Muccioli G, Eriksson PS, Isgaard J. Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells. Endocrinology 2008; 149: 2191-2199
11. Moon M, Kim S, Hwang L, Park S. Ghrelin regulates hip-pocampal neurogenesis in adult mice. Endocr J 2009; 56: 525-531
12. Duxbury MS, Waseem T, Ito H, Robinson MK, Zinner MJ, Ashley SW, Whang EE. Ghrelin promotes pancreatic adeno-carcinoma cellular proliferation and invasiveness. Biochem Biophys Res Commun 2003; 309: 464-468
13. Kim MS, Yoon CY, Jang PG, Park YJ, Shin CS, Park HS, Ryu JW, Pak YK, Park JY, Lee KU, Kim SY, Lee HK, Kim YB, Park KS. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 2004; 18: 2291-2301
14. Nanzer AM, Khalaf S, Mozid AM, Fowkes RC, Patel MV, Burrin JM, Grossman AB, Korbonits M. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J En-docrinol 2004; 151: 233-240
15. Levin F, Edholm T, Ehrström M, Wallin B, Schmidt PT, Kirchgessner AM, Hilsted LM, Hellström PM, Näslund E. Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat. Regul Pept 2005; 131: 59-65
16. Sibilia V, Lattuada N, Rapetti D, Pagani F, Vincenza D, Bulgarelli I, Locatelli V, Guidobono F, Netti C. Ghrelin inhibits infammatory pain in rats: involvement of the opioid system. Neuropharmacology 2006; 51: 497-505
17. Karam SM, Li Q, Gordon JI. Gastric epithelial morphogenesis in normal and transgenic mice. Am J Physiol 1997; 272(5 Pt 1): G1209-1220
18. Syder AJ, Karam SM, Mills JC, Ippolito JE, Ansari HR, Fa-rook V, Gordon JI. A transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotype. Proc Natl Acad Sci USA 2004; 101: 4471-4476
19. Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci USA 2004; 101: 8227-8232
20. Sibilia V, Rindi G, Pagani F, Rapetti D, Locatelli V, Torsello A, Campanini N, Deghenghi R, Netti C. Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 2003; 144: 353-359
21. Brzozowski T, Konturek PC, Konturek SJ, Kwiecień S, Drozdowicz D, Bielanski W, Pajdo R, Ptak A, Nikiforuk A, Pawlik WW, Hahn EG. Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage. Regul Pept 2004; 120: 39-51
22. Sibilia V, Pagani F, Rindi G, Lattuada N, Rapetti D, De Luca V, Campanini N, Bulgarelli I, Locatelli V, Guidobono F, Netti C. Central ghrelin gastroprotection involves nitric oxide/ prostaglandin cross-talk. Br J Pharmacol 2008; 154: 688-697
23. Karam SM, John R, Alpers DH, Ponery AS. Retinoic acid stimulates the dynamics of mouse gastric epithelial progenitors. Stem Cells 2005; 23: 433-441
24. Cohn SM, Lieberman MW. The use of antibodies to 5-bro-mo-2'-deoxyuridine for the isolation of DNA sequences containing excision-repair sites. J Biol Chem 1984; 259: 12456-12462
25. Karam SM. Lineage commitment and maturation of epithelial cells in the gut. Front Biosci 1999; 4: D286-D298
26. Liu YL, Malik NM, Sanger GJ, Andrews PL. Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents. Cancer Chemother Pharmacol 2006; 58: 326-333
27. Brzozowski T, Konturek PC, Sliwowski Z, Pajdo R, Droz-dowicz D, Kwiecien S, Burnat G, Konturek SJ, Pawlik WW. Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury. J Pharmacol Exp Ther 2006; 319: 477-487
28. Wu R, Dong W, Ji Y, Zhou M, Marini CP, Ravikumar TS, Wang P. Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion. PLoS One 2008; 3: e2026
29. Adami M, Pozzoli C, Leurs R, Stark H, Coruzzi G. Hista-mine H(3) receptors are involved in the protective effect of ghrelin against HCl-induced gastric damage in rats. Pharmacology 2010; 86: 259-266
30. Maccarinelli G, Sibilia V, Torsello A, Raimondo F, Pitto M, Giustina A, Netti C, Cocchi D. Ghrelin regulates proliferation and differentiation of osteoblastic cells. J Endocrinol 2005; 184: 249-256
31. Sato M, Nakahara K, Goto S, Kaiya H, Miyazato M, Date Y, Nakazato M, Kangawa K, Murakami N. Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord. Biochem Biophys Res Commun 2006; 350: 598-603