Structure of artificial and natural VE-cadherin-based adherens junctions

Biochemical Society Transactions

Volumn 36, Issue 2, 2008, Pages 189-193

  Taveau, Jean Christophe ^a   Dubois, Mathilde ^a   Le Bihan, Olivier ^a   Trépout, Sylvain ^a   Almagro, Sébastien ^b   Hewat, Elizabeth ^c   Durmort, Claire ^c   Heyraud, Stéphanie ^b   Gulino Debrac, Danielle ^b   Lambert, Olivier ^a  

^a CNRS   (France)

^b CEA GRENOBLE   (France)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

Annexin 2; Cryoelectron microscopy; Endothelial junction; Three dimensional reconstruction; Vascular endothelial cadherin (VE cadherin)

Indexed keywords

CATENIN; LIPOCORTIN 2; LIPOSOME; VASCULAR ENDOTHELIAL CADHERIN;

CELL ADHESION; CELL JUNCTION; CONFERENCE PAPER; CRYSTAL STRUCTURE; CYTOSKELETON; ENDOTHELIUM CELL; HUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN STRUCTURE; STRUCTURAL PROTEOMICS; X RAY CRYSTALLOGRAPHY;

ACTINS; ADHERENS JUNCTIONS; ANIMALS; CADHERINS; CELL ADHESION; CRYOELECTRON MICROSCOPY; ENDOTHELIUM, VASCULAR; HUMANS; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR;

EID: 42449163879     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360189     Document Type: Conference Paper

References (27)

1. Lampugnani, M.G., Resnati, M., Raiteri, M., Pigott, R., Pisacane, A., Houen, G., Ruco, L.P. and Dejana, E. (1992) A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J. Cell Biol. 118, 1511-1522
2. Dawes-Hoang, R.E., Parmar, K.M., Christiansen, A.E., Phelps, C.B., Brand, A.H. and Wieschaus, E.F. (2005) Folded gastrulation, cell shape change and the control of myosin localization. Development 132, 4165-4178
3. Gulino, D., Delachanal, E., Concord, E., Genoux, Y., Morand, B., Valiron, M.O., Sulpice, E., Scaife, R., Alemany, M. and Vernet, T. (1998) Alteration of endothelial cell monolayer integrity triggers resynthesis of vascular endothelium cadherin. J. Biol. Chem. 273, 29786-29793
4. Gory-Faure, S., Prandini, M.H., Pointu, H., Roullot, V., Pignot-Paintrand, I., Vernet, M. and Huber, P. (1999) Role of vascular endothelial-cadherin in vascular morphogenesis. Development 126, 2093-2102
5. Carmeliet, P., Lampugnani, M.G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oostuyse, B., Dewerchin, M. et al. (1999) Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98, 147-157
6. Corada, M., Zanetta, L., Orsenigo, F., Breviario, F., Lampugnani, M.G., Bernasconi, S., Liao, F., Hicklin, D.J., Bohlen, P. and Dejana, E. (2002) A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood 100, 905-911
7. May, C., Doody, J.F., Abdullah, R., Balderes, P., Xu, X., Chen, C.P., Zhu, Z., Shapiro, L., Kussie, P., Hicklin, D.J. et al. (2005) Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood 105, 4337-4344
8. Hatta, K., Nose, A., Nagafuchi, A. and Takeichi, M. (1988) Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family. J. Cell Biol. 106, 873-881
9. Takeichi, M. (1990) Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem. 59, 237-252
10. Gumbiner, B.M. (1996) Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84, 345-357
11. Shapiro, L., Fannon, A.M., Kwong, P.D., Thompson, A., Lehmann, M.S., Grubel, G., Legrand, J.F., Als-Nielsen, J., Colman, D.R. and Hendrickson, W.A. (1995) Structural basis of cell-cell adhesion by cadherins. Nature 374, 327-337
12. Overduin, M., Harvey, T.S., Bagby, S., Tong, K.I., Yau, P., Takeichi, M. and Ikura, M. (1995) Solution structure of the epithelial cadherin domain responsible for selective cell adhesion. Science 267, 386-389
13. Boggon, T.J., Murray, J., Chappuis-Flament, S., Wong, E., Gumbiner, B.M. and Shapiro, L. (2002) C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science 296, 1308-1313
14. Patel, S.D., Ciatto, C., Chen, C.P., Bahna, F., Rajebhosale, M., Arkus, N., Schieren, I., Jessell, T.M., Honig, B., Price, S.R. and Shapiro, L. (2006) Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell 124, 1255-1268
15. Parisini, E., Higgins, J.M., Liu, J.H., Brenner, M.B. and Wang, J.H. (2007) The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism. J. Mol. Biol. 373, 401-411
16. Shapiro, L., Love, J. and Colman, D.R. (2007) Adhesion molecules in the nervous system: structural insights into function and diversity. Annu. Rev. Neurosci. 30, 451-474
17. 2+-dependent hexameric structure. J. Biol. Chem. 276, 3581-3588
18. Bibert, S., Jaquinod, M., Concord, E., Ebel, C., Hewat, E., Vanbelle, C., Legrand, P., Weidenhaupt, M., Vernet, T. and Gulino-Debrac, D. (2002) Synergy between extracellular modules of vascular endothelial cadherin promotes homotypic hexameric interactions. J. Biol. Chem. 277, 12790-12801
19. Lambert, O., Taveau, J.C., Him, J.L.K., Al Kurdi, R., Gulino-Debrac, D. and Brisson, A. (2005) The basic framework of VE-cadherin junctions revealed by cryo-EM. J. Mol. Biol. 346, 1193-1196
20. Al-Amoudi, A., Norlen, L.P. and Dubochet, J. (2004) Cryo-electron microscopy of vitreous sections of native biological cells and tissues. J. Struct. Biol. 148, 131-135
21. Yap, A.S., Brieher, W.M., Pruschy, M. and Gumbiner, B.M. (1997) Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr. Biol. 7, 308-315
22. Hewat, E.A., Durmort, C., Jacquamet, L., Concord, E. and Gulino-Debrac, D. (2007) Architecture of the VE-cadherin hexamer. J. Mol. Biol. 365, 744-751
23. Sivasankar, S., Brieher, W., Lavrik, N., Gumbiner, B. and Leckband, D. (1999) Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains. Proc. Natl. Acad. Sci. U.S.A. 96, 11820-11824
24. Drochmans, P., Freudenstein, C., Wanson, J.C., Laurent, L., Keenan, T.W., Stadler, J., Leloup, R. and Franke, W.W. (1978) Structure and biochemical composition of desmosomes and tonofilaments isolated from calf muzzle epidermis. J. Cell Biol. 79, 427-443
25. He, W., Cowin, P. and Stokes, D.L. (2003) Untangling desmosomal knots with electron tomography. Science 302, 109-113
26. Yamada, S., Pokutta, S., Drees, F., Weis, W.I. and Nelson, W.J. (2005) Deconstructing the cadherin-catenin-actin complex. Cell 123, 889-901
27. Heyraud, S., Jaquinod, M., Durmort, C., Dambroise, E., Concord, E., Schaal, J.P., Huber, P. and Gulino-Debrac, D. (2008) Contribution of annexin 2 to the architecture of mature endothelial adherens junctions. Mol. Cell. Biol. 28, 1657-1668