Staphylococcus lugdunensis: The coagulase-negative staphylococcus you don't want to ignore

Expert Review of Anti-Infective Therapy

Volumn 9, Issue 10, 2011, Pages 901-907

  Babu, Elizabeth ^a   Oropello, John ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

coagulase negative; CoNS; endocarditis; invasive; Staphylococcus lugdunensis

Indexed keywords

AMINOGLYCOSIDE; CEFTAZIDIME; CIPROFLOXACIN; ERYTHROMYCIN; GENTAMICIN; MACROLIDE; PENICILLIN G; RIFAMPICIN; STREPTOMYCIN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; BACTERIAL ARTHRITIS; BACTERIAL ENDOCARDITIS; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; CARDIOVASCULAR INFECTION; CLINICAL FEATURE; COAGULASE NEGATIVE STAPHYLOCOCCUS; DISEASE ASSOCIATION; GEOGRAPHIC DISTRIBUTION; HUMAN; INFECTION RISK; MORTALITY; NONHUMAN; PROGNOSIS; REVIEW; RISK ASSESSMENT; RISK FACTOR; SPONDYLITIS; STAPHYLOCOCCUS LUGDUNENSIS;

ABSCESS; ANTI-BACTERIAL AGENTS; ARTHRITIS, INFECTIOUS; BACTERIAL PROTEINS; BACTERIAL TYPING TECHNIQUES; COAGULASE; DISEASE MANAGEMENT; ENDOCARDITIS, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; OSTEOMYELITIS; SHOCK, SEPTIC; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS LUGDUNENSIS; TREATMENT OUTCOME; UNITED STATES;

EID: 80053624356     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.11.110     Document Type: Review

References (89)

1. Pfaller MA, Jones RN, Doern GV, Sader HS, Kugler KC, Beach ML. Survey of blood stream infections attributable to Gram-positive cocci: Frequency of occurrence and antimicrobial susceptibility of isolates collected in 1997 in the United States, Canada, and Latin America from the SENTRY Antimicrobial Surveillance Program. SENTRY Participants Group. Diagn. Microbiol. Infect. Dis. 33(4), 283-297 (1999 (Pubitemid 29142369)
2. Jarlov JO, Hojbjerg T, Busch-Sorensen C et al. Coagulase-negative staphylococci in Danish blood cultures: Species distribution and antibiotic susceptibility. J. Hosp. Infect. 32(3), 217-227 (1996 (Pubitemid 26135146)
3. Shin JH, Jung HJ, Lee HR, Kim JH, Kim HR, Lee JN. Prevalence, identification, and antimicrobial susceptibility of Staphylococcus lugdunensis from various clinical specimens in Korea. Jpn J. Infect. Dis. 60(5), 312-313 (2007 (Pubitemid 47516882)
4. Choi SH, Chung JW, Lee EJ et al. Incidence, characteristics, and outcomes of Staphylococcus lugdunensis bacteremia. J. Clin. Microbiol. 48(9), 3346-3349 (2010
5. Kawamura Y, Hou XG, Sultana F et al. Distribution of Staphylococcus species among human clinical specimens and emended description of Staphylococcus caprae. J. Clin. Microbiol. 36(7), 2038-2042 (1998 (Pubitemid 28277798)
6. De Paulis AN, Predari SC, Chazarreta CD, Santoianni JE. Five-test simple scheme for species-level identification of clinically significant coagulase-negative staphylococci. J. Clin. Microbiol. 41(3), 1219-1224 (2003 (Pubitemid 36307131)
7. Kleeman KT, Bannerman TL, Kloos WE. Species distribution of coagulase-negative staphylococcal isolates at a community hospital and implications for selection of staphylococcal identification procedures. J. Clin. Microbiol. 31(5), 1318-1321 (1993 (Pubitemid 23129468)
8. Kleiner E, Monk AB, Archer GL, Forbes BA. Clinical significance of Staphylococcus lugdunensis isolated from routine cultures. Clin. Infect. Dis. 51(7), 801-803 (2010
9. Herchline TE, Ayers LW. Occurrence of Staphylococcus lugdunensis in consecutive clinical cultures and relationship of isolation to infection. J. Clin. Microbiol. 29(3), 419-421 (1991
10. Bieber L, Kahlmeter G. Staphylococcus lugdunensis in several niches of the normal skin flora. Clin. Microbiol. Infect. 16(4), 385-388 (2010
11. Freney J. Staphylococcus lugdunensis sp. nov. and Staphylococcus schleiferi sp. nov., two species from human clinical specimens. Int. J. Syst. Bacteriol. 38(2), 168-172 (1988
12. Pirila L, Soderstrom KO, Hietarinta M, Jalava J, Kyto V, Toivanen A. Fatal myocardial necrosis caused by Staphylococcus lugdunensis and cytomegalovirus in a patient with scleroderma. J. Clin. Microbiol. 44(6), 2295-2297 (2006 (Pubitemid 43902199)
13. Bhanot N, Sahud AG, Bhat S, Lane S, Manyam H, Chan-Tompkins NH. Fever of unknown origin: A case of cardiac myxoma infected with Staphylococcus lugdunensis. South. Med. J. 103(7), 697-700 (2010
14. Patil R, Patil T, Hussain KM. Staphylococcus lugdunensis native tricuspid valve endocarditis: A case report and review of literature. J. Gen. Intern. Med. DOI: 10.1007/s11606-011-1718-5 (2011) (Epub ahead of print
15. Longauerova A. Coagulase negative staphylococci and their participation in pathogenesis of human infections. Bratisl. Lek. Listy 107(11-12), 448-452 (2006
16. Liu PY, Huang YF, Tang CW et al. Staphylococcus lugdunensis infective endocarditis: A literature review and analysis of risk factors. J. Microbiol. Immunol. Infect. 43(6), 478-484 (2010
17. Van Hoovels L, De Munter P, Colaert J et al. Three cases of destructive native valve endocarditis caused by Staphylococcus lugdunensis. Eur. J. Clin. Microbiol. Infect. Dis. 24(2), 149-152 (2005 (Pubitemid 40487386)
18. De Hondt G, Ieven M, Vandermersch C, Colaert J. Destructive endocarditis caused by Staphylococcus lugdunensis. Case report and review of the literature. Acta. Clin. Belg. 52(1), 27-30 (1997 (Pubitemid 27132500)
19. Koh TW, Brecker SJ, Layton CA. Successful treatment of Staphylococcus lugdunensis endocarditis complicated by multiple emboli: A case report and review of the literature. Int. J. Cardiol. 55(2), 193-197 (1996 (Pubitemid 26246917)
20. Anguera I, Del Rio A, Miro JM et al. Staphylococcus lugdunensis infective endocarditis: Description of 10 cases and analysis of native valve, prosthetic valve, and pacemaker lead endocarditis clinical profiles. Heart 91(2), e10 (2005
21. Baddour LM, Bettmann MA, Bolger AF et al. Nonvalvular cardiovascular device-related infections. Clin. Infect. Dis. 38(8), 1128-1130 (2004 (Pubitemid 38951259)
22. Kamaraju S, Nelson K, Williams DN, Ayenew W, Modi KS. Staphylococcus lugdunensis pulmonary valve endocarditis in a patient on chronic hemodialysis. Am. J. Nephrol. 19(5), 605-608 (1999
23. Matthews PC, Missouris CG, Jordaan J, Lessing MP. Staphylococcus lugdunensis endocarditis following cardiac catheterisation. Int. J. Cardiol. 130(1), 87-88 (2008
24. Polenakovik H, Herchline T, Bacheller C, Bernstein J. Staphylococcus lugdunensis endocarditis after angiography. Mayo Clin. Proc. 75(6), 656-657 (2000
25. Fervenza FC, Contreras GE, Garratt KN, Steckelberg JM. Staphylococcus lugdunensis endocarditis: A complication of vasectomy? Mayo Clin. Proc. 74(12), 1227-1230 (1999
26. Patel R, Piper KE, Rouse MS, Uhl JR, Cockerill FR 3rd, Steckelberg JM. Frequency of isolation of Staphylococcus lugdunensis among staphylococcal isolates causing endocarditis: A 20-year experience. J. Clin. Microbiol. 38(11), 4262-4263 (2000 (Pubitemid 32233241)
27. Kragsbjerg P, Bomfim-Loogna J, Tornqvist E, Soderquist B. Development of antimicrobial resistance in Staphylococcus lugdunensis during treatment-report of a case of bacterial arthritis, vertebral osteomyelitis and infective endocarditis. Clin. Microbiol. Infect. 6(9), 496-499 (2000 (Pubitemid 34966068)
28. Karchmer AW, Longworth DL. Infections of intracardiac devices. Cardiol. Clin. 21(2), 253-271, vii (2003
29. Greig JM, Wood MJ. Staphylococcus lugdunensis vertebral osteomyelitis. Clin. Microbiol. Infect. 9(11), 1139-1141 (2003 (Pubitemid 37428055)
30. Cooke RP, James SE, Sallomi DF. Infective discitis due to Staphylococcus lugdunensis-a case of missed opportunity. Br. J. Biomed. Sci. 60(3), 162-164 (2003 (Pubitemid 37204577)
31. Guttmann G, Garazi S, Van Linthoudt D. Spondylodiscitis due to Staphylococcus lugdunensis. Clin. Exp. Rheumatol. 18(2), 271-272 (2000
32. Murdoch DR, Everts RJ, Chambers ST, Cowan IA. Vertebral osteomyelitis due to Staphylococcus lugdunensis. J. Clin. Microbiol. 34(4), 993-994 (1996 (Pubitemid 26091527)
33. Thomas S, Hoy C, Capper R. Osteomyelitis of the ear canal caused by Staphylococcus lugdunensis. J. Infect. 53(5), e227-e229 (2006 (Pubitemid 44524710)
34. Mei-Dan O, Mann G, Steinbacher G, Ballester SJ, Cugat RB, Alvarez PD. Septic arthritis with Staphylococcus lugdunensis following arthroscopic ACL revision with BPTB allograft. Knee Surg. Sports Traumatol. Arthrosc. 16(1), 15-18 (2008
35. Sampathkumar P, Osmon DR, Cockerill FR 3rd. Prosthetic joint infection due to Staphylococcus lugdunensis. Mayo. Clin. Proc. 75(5), 511-512 (2000 (Pubitemid 30252374)
36. Weightman NC, Allerton KE, France J. Bone and prosthetic joint infection with Staphylococcus lugdunensis. J. Infect. 40(1), 98-99 (2000 (Pubitemid 30157785)
37. Zinkernagel AS, Zinkernagel MS, Elzi MV et al. Significance of Staphylococcus lugdunensis bacteremia: Report of 28 cases and review of the literature. Infection 36(4), 314-321 (2008
38. Woznowski M, Quack I, Bolke E et al. Fulminant Staphylococcus lugdunensis septicaemia following a pelvic varicella-zoster virus infection in an immune-deficient patient: A case report. Eur. J. Med. Res. 15(9), 410-414 (2010
39. Castro JG, Dowdy L. Septic shock caused by Staphylococcus lugdunensis. Clin. Infect. Dis. 28(3), 681-682 (1999 (Pubitemid 29242553)
40. Pareja J, Gupta K, Koziel H. The toxic shock syndrome and Staphylococcus lugdunensis bacteremia. Ann. Intern. Med. 128(7), 603-604 (1998 (Pubitemid 28177677)
41. Fadel HJ, Patel R, Vetter EA, Baddour LM. Clinical significance of a single Staphylococcus lugdunensis-positive blood culture. J. Clin. Microbiol. 49(4), 1697-1699 (2011
42. Tan TY, Ng SY, Ng WX. Clinical significance of coagulase-negative staphylococci recovered from nonsterile sites. J. Clin. Microbiol. 44(9), 3413-3414 (2006 (Pubitemid 44413792)
43. Arias M, Tena D, Apellaniz M et al. Skin and soft tissue infections caused by Staphylococcus lugdunensis: Report of 20 cases. Scand. J. Infect. Dis 42(11-12), 879-884 (2010
44. Bellamy R, Barkham T. Staphylococcus lugdunensis infection sites: Predominance of abscesses in the pelvic girdle region. Clin. Infect. Dis. 35(3), E32-E34 (2002
45. Bocher S, Tonning B, Skov RL, Prag J. Staphylococcus lugdunensis, a common cause of skin and soft tissue infections in the community. J. Clin. Microbiol. 47(4), 946-950 (2009
46. Asnis DS, St John S, Tickoo R, Arora A. Staphylococcus lugdunensis breast abscess: Is it real? Clin. Infect. Dis. 36(10), 1348 (2003 (Pubitemid 36629950)
47. Lina B, Vandenesch F, Reverdy ME, Greenland T, Fleurette J, Etienne J. Non-puerperal breast infections due to Staphylococcus lugdunensis. Eur. J. Clin. Microbiol. Infect. Dis. 13(8), 686-687 (1994 (Pubitemid 24286875)
48. Matthews PC, Lazarus R, Protheroe A, Milford C, Bowler IC. Acute necrotizing sinusitis caused by Staphylococcus lugdunensis. J. Clin. Microbiol. 49(7), 2740-2742 (2011
49. Shaaban HS, Choo HF, Sensakovic JW. A case of Staphylococcus lugdunensis related pyomyoma occurring after cesarean section. J. Glob. Infect. Dis. 3(1), 101-102 (2011
50. Bello C, Eskandar M, El GR, Sobande A, Nour H, Shafiq H. Staphylococcus lugdunensis endometritis: A case report. West Afr. J. Med. 26(3), 243-245 (2007
51. Tamdy A, El Louali F, Ounzar M et al. Multiple mycotic aneurysms reveal Staphylococcus lugdunensis endocarditis in a young patient. Heart Lung 40(4), 352-357 (2011
52. Spanu T, Rigante D, Tamburrini G et al. Ventriculitis due to Staphylococcus lugdunensis: Two case reports. J. Med. Case Reports 2, 267 (2008
53. Elliott SP, Yogev R, Shulman ST. Staphylococcus lugdunensis: An emerging cause of ventriculoperitoneal shunt infections. Pediatr. Neurosurg. 35(3), 128-130 (2001 (Pubitemid 32973986)
54. Sandoe JA, Longshaw CM. Ventriculoperitoneal shunt infection caused by Staphylococcus lugdunensis. Clin. Microbiol. Infect. 7(7), 385-387 (2001 (Pubitemid 34960322)
55. Fleurette J, Bes M, Brun Y et al. Clinical isolates of Staphylococcus lugdunensis and S. schleiferi: Bacteriological characteristics and susceptibility to antimicrobial agents. Res. Microbiol. 140(2), 107-118 (1989 (Pubitemid 19129860)
56. Ludlam H, Phillips I. Staphylococcus lugdunensis peritonitis. Lancet 2(8676), 1394 (1989 (Pubitemid 20003002)
57. Bannerman TL, Rhoden DL, Mcallister SK, Miller JM, Wilson LA. The source of coagulase-negative staphylococci in the Endophthalmitis Vitrectomy Study. A comparison of eyelid and intraocular isolates using pulsed-field gel electrophoresis. Arch. Ophthalmol. 115(3), 357-361 (1997
58. Chiquet C, Pechinot A, Creuzot-Garcher C et al. Acute postoperative endophthalmitis caused by Staphylococcus lugdunensis. J. Clin. Microbiol. 45(6), 1673-1678 (2007 (Pubitemid 46933890)
59. Giese B, Glowinski F, Paprotka K et al. Expression of d-toxin by Staphylococcus aureus mediates escape from phago-endosomes of human epithelial and endothelial cells in the presence of b-toxin. Cell Microbiol. 13(2), 316-329 (2011
60. Bera A, Biswas R, Herbert S, Gotz F. The presence of peptidoglycan O-acetyltransferase in various staphylococcal species correlates with lysozyme resistance and pathogenicity. Infect. Immun. 74(8), 4598-4604 (2006 (Pubitemid 44157247)
61. Paulsson M, Petersson AC, Ljungh A. Serum and tissue protein binding and cell surface properties of Staphylococcus lugdunensis. J. Med. Microbiol. 38(2), 96-102 (1993 (Pubitemid 23057132)
62. Zhang YQ, Ren SX, Li HL et al. Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228). Mol. Microbiol. 49(6), 1577-1593 (2003
63. Von Eiff C, Peters G, Heilmann C. Pathogenesis of infections due to coagulase-negative staphylococci. Lancet Infect. Dis. 2(11), 677-685 (2002 (Pubitemid 35265063)
64. Stout RD, Ferguson KP, Li YN, Lambe DW Jr. Staphylococcal exopolysaccharides inhibit lymphocyte proliferative responses by activation of monocyte prostaglandin production. Infect. Immun. 60(3), 922-927 (1992
65. Grant CE, Sewell DL, Pfaller M, Bumgardner RV, Williams JA. Evaluation of two commercial systems for identification of coagulase-negative staphylococci to species level. Diagn. Microbiol. Infect. Dis 18(1), 1-5 (1994 (Pubitemid 24117052)
66. Kloos WE, George CG. Identification of Staphylococcus species and subspecies with the MicroScan Pos ID and Rapid Pos ID panel systems. J. Clin. Microbiol. 29(4), 738-744 (1991
67. Mateo M, Maestre JR, Aguilar L et al. Genotypic versus phenotypic characterization, with respect to susceptibility and identification, of 17 clinical isolates of Staphylococcus lugdunensis. J. Antimicrob. Chemother. 56(2), 287-291 (2005 (Pubitemid 41158515)
68. Carroll KC, Weinstein MP. Manual of Clinical Microbiology. ASM Press, Washington DC, USA (2007
69. Leung MJ, Nuttall N, Pryce TM, Coombs GW, Pearman JW. Colony variation in Staphylococcus lugdunensis. J. Clin. Microbiol. 36(10), 3096-3098 (1998 (Pubitemid 28429452)
70. Fadel HJ, Patel R, Vetter EA, Baddour LM. The clinical significance of a single positive blood culture for Staphylococcus lugdunensis. J. Clin. Microbiol. 49(4), 1697-1699 (2011
71. Pinsky BA, Samson D, Ghafghaichi L, Baron EJ, Banaei N. Comparison of real-time PCR and conventional biochemical methods for identification of Staphylococcus lugdunensis. J. Clin. Microbiol. 47(11), 3472-3477 (2009
72. Arciola CR, Campoccia D, An YH et al. Prevalence and antibiotic resistance of 15 minor staphylococcal species colonizing orthopedic implants. Int. J. Artif. Organs 29(4), 395-401 (2006
73. Vandenesch F, Etienne J, Reverdy ME, Eykyn SJ. Endocarditis due to Staphylococcus lugdunensis: Report of 11 cases and review. Clin. Infect. Dis. 17(5), 871-876 (1993 (Pubitemid 23321906)
74. Higaki S, Kitagawa T, Morohashi M, Yamagishi T. Distribution and antimicrobial susceptibility of coagulase-negative staphylococci from skin lesions. J. Int. Med. Res. 27(4), 191-195 (1999 (Pubitemid 29520894)
75. Goldstein EJ, Citron DM, Merriam CV, Warren YA, Tyrrell KL, Fernandez HT. In vitro activity of ceftobiprole against aerobic and anaerobic strains isolated from diabetic foot infections. Antimicrob. Agents Chemother. 50(11), 3959-3962 (2006 (Pubitemid 44684928)
76. Woods W, Ramotar K, Lem P, Toye B. Oxacillin susceptibility testing of coagulase-negative staphylococci using the disk diffusion method and the Vitek GPS-105 card( small star, filled). Diagn. Microbiol. Infect. Dis 42(4), 291-294 (2002 (Pubitemid 34460583)
77. Van Der Mee-Marquet N, Achard A, Mereghetti L, Danton A, Minier M, Quentin R. Staphylococcus lugdunensis infections: High frequency of inguinal area carriage. J. Clin. Microbiol. 41(4), 1404-1409 (2003 (Pubitemid 36428080)
78. Hellbacher C, Tornqvist E, Soderquist B. Staphylococcus lugdunensis: Clinical spectrum, antibiotic susceptibility, and phenotypic and genotypic patterns of 39 isolates. Clin. Microbiol. Infect. 12(1), 43-49 (2006 (Pubitemid 43372238)
79. Frank KL, Reichert EJ, Piper KE, Patel R. In vitro effects of antimicrobial agents on planktonic and biofilm forms of Staphylococcus lugdunensis clinical isolates. Antimicrob. Agents Chemother. 51(3), 888-895 (2007 (Pubitemid 46355272)
80. Tee W. Staphylococcus lugdunensis carrying the mecA gene causes catheter-associated bloodstream infection in premature neonate. J. Clin. Microbiol. 41(1), 519-520 (2003 (Pubitemid 36098640)
81. Becker K, Pagnier I, Schuhen B et al. Does nasal cocolonization by methicillin-resistant coagulase-negative staphylococci and methicillin- susceptible Staphylococcus aureus strains occur frequently enough to represent a risk of false-positive methicillin-resistant S. aureus determinations by molecular methodŝ J. Clin. Microbiol. 44(1), 229-231 (2006 (Pubitemid 43100608)
82. Pereira EM, Schuenck RP, Nouer SA, Santos KR. Methicillin-resistant Staphylococcus lugdunensis carrying SCCmec type V misidentified as MRSA. Braz. J. Infect. Dis. 15(3), 293-295 (2011
83. Kawaguchi E, Minamide W, Mori H, Igimi H. [The taxonomic distribution, characteristic and susceptibility against antimicrobial agents of methicillin-resistant staphylococci isolated from blood]. Kansenshogaku Zasshi 70(11), 1147-1153 (1996
84. Wu AB, Wang MC, Tseng CC et al. Clinical and microbiological characteristics of community-acquired Staphylococcus lugdunensis infections in Southern Taiwan. J. Clin. Microbiol. 49(8), 3015-3018 (2011
85. Kotsakis SD, Tzouvelekis LS, Zerva L, Liakopoulos A, Petinaki E. Staphylococcus lugdunensis strain with a modified PBP1A/1B expressing resistance to b-lactams. Eur. J. Clin. Microbiol. Infect. Dis. DOI: 10.1007/s10096-011- 1289-8 (2011) (Epub ahead of print
86. Wilson W, Taubert KA, Gewitz M et al. Prevention of infective endocarditis: Guidelines from the American Heart Association: A guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation 116(15), 1736-1754 (2007
87. Mendes RE, Sader HS, Jones RN. Activity of telavancin and comparator antimicrobial agents tested against Staphylococcus spp. isolated from hospitalised patients in Europe (2007-2008). Int. J. Antimicrob. Agents 36(4), 374-379 (2010
88. Merino P, Arribi A, Gestoso I, Picazo J, Gimeno L, Del Potro E. Linezolid treatment of a prosthetic joint infection with Staphylococcus lugdunensis in a patient with multiple myeloma. Int. J. Antimicrob. Agents 35(2), 203-204 (2010
89. Baddour LM, Wilson WR, Bayer AS et al. Infective endocarditis: Diagnosis, antimicrobial therapy, and management of complications: A statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: Endorsed by the Infectious Diseases Society of America. Circulation 111(23), e394-e434 (2005).