Preparation of triazolobenzodiazepine derivatives as Vasopressin V1a antagonists

Tetrahedron Letters

Volumn 52, Issue 45, 2011, Pages 5913-5917

  Beal, David M ^a   Bryans, Justin S ^a   Johnson, Patrick S ^a   Newman, Julie ^a   Pasquinet, Christelle ^a   Peakman, Torren M ^a   Ryckmans, Thomas ^a   Underwood, Toby J ^a   Wheeler, Simon ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Atropisomer; Triazole; Triazolobenzodiazepines; Tricyclic; Vasopressin V1a

Indexed keywords

BENZODIAZEPINE DERIVATIVE; TRIAZOLE DERIVATIVE; TRIAZOLOBENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG; VASOPRESSIN RECEPTOR ANTAGONIST; VASOPRESSIN V1A RECEPTOR ANTAGONIST;

ALKYLATION; ARTICLE; CYCLIZATION; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 80053605025     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.08.011     Document Type: Article

References (16)

1. T. Ryckmans Annu. Rep. Med. Chem. 44 2009 129
2. G. Cignarella, S. Villa, and D. Barlocco Farmaco 48 1993 1439
3. S. Liras, M.P. Allen, and B.E. Segelstein Synth. Commun. 30 2000 437
4. E.M. Burgess, H.R. Penton, and E.A. Taylor J. Org. Chem. 38 1973 26
5. C.T. Brain, J.M. Paul, Y. Loong, and P.J. Oakley Tetrahedron Lett. 40 1999 3275
6. P. Sabbatini, P. Wellendorph, S. Hoeg, M.H.F. Pedersen, H. Brauner-Osborne, L. Martiny, B. Froelund, and R.P. Clausen J. Med. Chem. 53 2010 6506
7. L. Pignataro, S. Carboni, M. Civera, R. Colombo, U. Piarulli, and C. Gennari Angew. Chem., Int. Ed. 49 2010 6633
8. H. Günther NMR Spectroscopy. Basic Principles, Concepts, and Applications in Chemistry 2nd ed. 1995 John Wiley and Sons Chichester p 335
9. E.L. Eliel, and S.H. Wilen Stereochemistry of Organic Compounds 1994 John Wiley and Sons New York p 1142
10. R. Guryn Polish. J. Chem. 63 1989 265
11. M. Uskokovic, G. Grethe, J. Iacobelli, and W. Wenner J. Org. Chem. 30 1965 3111
12. A. Ben-Haida, H.M. Colquhoun, P. Hodge, J. Raftery, A.J.P. White, and D.J. Williams Org. Biomol. Chem. 7 2009 5229
13. K.S. Ravikumar, Y.M. Zhang, J. Begue, and D. Bonnet-Delpon Eur. J. Org. Chem. 1998 2937
14. Genet, Alain; Lagrange, Alain. (L'Oreal, Fr.). Eur. Pat. Appl. (1999), EP 911317 A1 19990428.
15. L. Fumagalli, C. Bolchi, S. Colleoni, M. Gobbi, B. Moroni, M. Pallavicini, A. Pedretti, L. Villa, G. Vistoli, and E. Valoti Bioorg. Med. Chem. 13 2005 2547
16. F. Hirayama, H. Koshio, N. Katayama, T. Ishihara, H. Kaizawa, Y. Taniuchi, K. Sato, Y. Sakai-Moritani, S. Kaku, H. Kurihara, T. Kawasaki, Y. Matsumoto, S. Sakamoto, and S. Tsukamoto Bioorg. Med. Chem. 11 2003 367