Asymptomatic macrothrombocytopenia in a young pure-bred beagle dog: A case report

Toxicologic Pathology

Volumn 39, Issue 6, 2011, Pages 980-987

  Bodié, Karen ^a   Gagne, Gerard D ^b   Sramek, Mary K ^b   Desmond, David J ^b   Abel, Stephen J ^b   Fagerland, Jane A ^b  

^a ABBOTT GMBH AND CO KG   (Germany)

^b ABBOTT LABORATORIES   (United States)

Author keywords

clinical pathology; dog; genotyping; macrothrombocytopenia; ultrastructure

Indexed keywords

ANTINUCLEAR ANTIBODY; GLUCOCORTICOID; PREDNISONE; TUBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; BLEEDING TIME; BORRELIA BURGDORFERI; CONTROLLED STUDY; DOG; EHRLICHIA CANIS; ENDOPLASMIC RETICULUM; GENE MUTATION; GENOTYPE; MALE; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; RICKETTSIA RICKETTSII; THROMBOCYTE COUNT; THROMBOCYTOPENIA; WILD TYPE;

ANIMALS; BLOOD PLATELETS; BORRELIA BURGDORFERI; DOGS; EHRLICHIA CANIS; ERYTHROCYTES; GENOTYPE; GLUCOCORTICOIDS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PLATELET COUNT; PREDNISONE; RICKETTSIA RICKETTSII; THROMBOCYTOPENIA;

BORRELIA BURGDORFERI; CANIS FAMILIARIS; EHRLICHIA CANIS; MOROCCAN PEPPER VIRUS; RICKETTSIA RICKETTSII;

EID: 80053598135     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311416261     Document Type: Article

References (29)

1. Adhikari P., Hegde B. M., Pereira P., Bhat P., Chowta N., Ramesh K. V., Venkatadri T. V.. Evaluation of safety and efficacy of azithromycin in lower respiratory tract infections (LRTI)*. Indian J Med Sci. 1996 ; 50: 313-17
2. Aster R. H.. Can drugs cause autoimmune thrombocytopenic purpura?. Semin Hematol. 2000 ; 37 (3). 229-38 (Pubitemid 30612901)
3. Aster R. H., Bougie D. W.. Drug-induced immune thrombocytopenia. N Engl J Med. 2007 ; 357: 580-87 (Pubitemid 47236283)
4. Bulla C., Kiomi Takahira R., Pessoa Araújo J., Trinca L. A., Souza Lopes R., Edward Wiedmeyer C.. The relationship between the degree of thrombocytopenia and infection with Ehrlichia canis in an endemic area. Vet Res. 2004 ; 35: 141-46 (Pubitemid 38380156)
5. Côté E. Clinical Veterinary Advisor: Dogs and Cats. St Louis, MO: Mosby Elsevier ; 2007 :
6. Cowan S. M., Bartges J. W., Gompf R. E., Hayes J. R., Moyers T. D., Snider C. C., Gerard D. A., Craft R. M., Muenchen R. A., Carroll R. C.. Giant platelet disorder in the Cavalier King Charles Spaniel. Exp Hematol. 2004 ; 32: 344-50 (Pubitemid 38410910)
7. Dameron G. W., Weingand K. W., Duderstadt J. M., Odioso L. W., Dierckman T. A., Schwecke W., Baran K.. Effect of bleeding site on clinical laboratory testing of rats: Orbital venous plexus versus posterior vena cava. Lab Anim Sci. 1992 ; 42 (3). 299-301
8. Davis B., Toivio-Kinnucan M., Schuller S., Boudreaux M. K.. Mutation in β1-Tubulin correlates with macrothrombocytopenia in Cavalier King Charles Spaniels. J Vet Intern Med. 2008 ; 22: 540-45
9. Dodds W. J.. Vaccine protocols for dogs predisposed to vaccine reactions. J Am An Hos Ass. 2001 ; 37: 1-4
10. Grindem C. B., Breitschwerdt E. B., Perkins P. C., Cullins L. D., Thomas T. J., Hegarty B. C.. Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky Mountain spotted fever and ehrlichiosis. J Am Anim Hosp Assoc. 1999 ; 35: 56-61 (Pubitemid 129761584)
11. Handagama P. J., Feldman B. F.. Drug-induced thrombocytopenia. Vet Res Com. 1986 ; 10: 1-20 (Pubitemid 16181496)
12. Jackson M. L., Kruth S. A.. Immune-mediated hemolytic anemia and thrombocytopenia in the dog: A retrospective study of 55 cases diagnosed from 1969 through 1983 at the Western College of Veterinary Medicine. Can Vet J. 1985 ; 26: 245-50
13. Kuter D. J., Hunt P., Sheridan W., Zucker-Franklin D. Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology. Totowa, NJ: Humana Press ; 1997 :
14. Lewis D. C., Meyers K. M.. Canine Idiopathic Thrombocytopenic Purpura. J Vet Intern Med. 1996a ; 10: 207-18 (Pubitemid 126701141)
15. Lewis D. C., Meyers K. M.. Studies of platelet-bound and serum platelet-bindable immunoglobulins in dogs with idiopathic thrombocytopenic purpura. Exp Hematol. 1996b ; 24: 696-701 (Pubitemid 26182834)
16. Maldonado J. E., Pintado T., Pierre R. V.. Dysplastic platelets and circulating megacaryocytes in chronic myeloproliferative disease. I. The platelets: Ultrastructure and peroxidase reaction. Blood. 1974 ; 43 (3). 797-809
17. McGuire B. Small Animal Physical Diagnosis and Clinical Procedures. McCurnin D. M. Poffenbarger E. M., ed. Philadelphia, PA: W.B. Saunders ; 1991: 192-94.
18. Mhawech P., Saleem A.. Inherited giant platelet disorders classification and literature review. Am J Clin Pathol. 2000 ; 113: 176-90 (Pubitemid 30212549)
19. Pantonawitz L.. Mechanisms of thrombocytopenia in tick-borne diseases. Internet J Infect Dis. 2003 ; 2 ( 2 ):
20. Pedersen H. D., Häggström J., Olsen L. H., Christensen K., Selin A., Burmeister M. L., Larsen H.. Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive trait. J Vet Intern Med. 2002 ; 16: 169-73 (Pubitemid 135746941)
21. Putsche J. C., Kohn B.. Primary immune-mediated thrombocytopenia in 30 dogs (1997-2003). J Am Anim Hosp Assoc. 2008 ; 44: 250-57
22. Russel K. E., Grindem C. B. Schalm's Veterinary Hematology. Feldmann B. F. Zinkel J. G. Jain N. C., ed. Philadelphia, PA: Lippincott Williams & Wilkins ; 2000: 487-95.
23. Scott M. A. Schalm's Veterinary Hematology. Feldmann B. F. Zinkel J. G. Jain N. C., ed. Philadelphia, PA: Lippincott Williams & Wilkins ; 2000: 478-86.
24. Singh M. K., Lamb W. A.. Idiopathic thrombocytopenia in Cavalier King Charles Spaniels. Aust Vet J. 2005 ; 83: 700-3
25. Tablin F. Schalm's Veterinary Hematology. Feldmann B. F. Zinkel J. G. Jain J. C., ed. Philadelphia, PA: Lippincott Williams & Wilkins ; 2000: 250-52.
26. Weiss D. J. Schalm's Veterinary Hematology. Feldmann B. F. Zinkel J. G. Jain N. C., ed. Philadelphia, PA: Lippincott Williams & Wilkins ; 2000: 469-71.
27. Wilkerson M. J., Shuman W., Swist S., Harkin K., Meinkoth J., Kocan A. A.. Platelet size, platelet surface-associated IgG, and reticulated platelets in dogs with immune-mediated thrombocytopenia. Vet Clin Pathol. 2001 ; 30: 141-49
28. Zimmerman K. L. Schalm's Veterinary Hematology. Feldmann B. F. Zinkel J. G. Jain N. C., ed. Philadelphia, PA: Lippincott Williams & Wilkins ; 2000: 472-77.
29. Zucker-Franklin D. Hematology Fourth Edition. Williams W. J. Beutler E. Erslev A. J. Lichtman M. A., ed. New York, NY: McGraw-Hill ; 1990: 1172-73.