Idiopathic asymptomatic thrombocytopenia in Cavalier King Charles Spaniels is an autosomal recessive trait

Journal of Veterinary Internal Medicine

Volumn 16, Issue 2, 2002, Pages 169-173

  Pedersen, Henrik D ^a   Häggström, Jens ^b   Olsen, Lisbeth H ^a   Christensen, Knud ^a   Selin, Anna ^b   Burmeister, Malene L ^a   Larsen, Heidi ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Dog; Inherited condition; Macrothrombocytopenia; Platelets

Indexed keywords

ANIMAL; ANIMAL DISEASE; ARTICLE; AUTOANALYSIS; BLOOD; CELL SIZE; CHROMOSOME ABERRATION; DOG; DOG DISEASE; FEMALE; GENETICS; MALE; METHODOLOGY; PEDIGREE; RECESSIVE GENE; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ANIMALS; AUTOANALYSIS; CELL SIZE; CHROMOSOME ABERRATIONS; DOG DISEASES; DOGS; FEMALE; GENES, RECESSIVE; MALE; PEDIGREE; PLATELET COUNT; THROMBOCYTOPENIA;

EID: 0036519080     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2002.tb02350.x     Document Type: Article

References (21)

1. Brown SJ, Simpson KW, Baker S, et al. Macrothrombocytosis in Cavalier King Charles Spaniels. Vet Rec 1994; 135:281-283.
2. Eksell P, Häggstrom J, Kvart C, Karlsson Å. Thrombocytopenia in Cavalier King Charles Spaniels,. J Small Anim Pract 1994;35:153-155.
3. Smedile LE, Houston DM, Taylor SM, et al. Idiopathic, asymptomatic thrombocytopenia in Cavalier King Charles Spaniels: 11 cases (1983-1993). J Am Anim Hosp Assoc 1997;33:411-415
4. Olsen LH, Kristensen AT, Häggstrom J, et al. Increased platelet aggregation response in Cavalier King Charles Spaniels with mitral valve prolapse. J Vet Intern Med 2001,15:209-216.
5. Novak EK, Reddington M, Zhen L, et al. Inherited thrombocytopenia caused by reduced platelet production in mice with the gunmetal pigment gene mutation. Blood 1995;85:1781-1789.
6. Jackson CW, Huston NK, Steward SA, et al. The Wistar Furth rat: An animal model of hereditary macrothrombocytopenia. Blood 1988;71.1676-1686.
7. Mhawech P, Saleem A. Inherited giant platelet disorders. Classification and literature review. Am J Clin Pathol 2000;113.176-190.
8. Jantunen E. Inherited giant platelet disorders. Eur J Haematol 1994;53:191-196.
9. Thrusfield MV, Aikten CGG, Darke PGG. Observations on breed and sex in relation to canine heart valve incompetence. J Small Anim Pract 1985;26:709-717.
10. Haggström J. Chronic Valvular Disease in Cavalier King Charles Spaniels. Epidemiology. Inheritance and Pathophysiology. Uppsala. Sweden: Swedish University of Agricultural Sciences; 1996. Thesis
11. Brodie HA, Chole RA, Griffin GC, White JG. Macrothrombo-cytopenia and progressive deafness: A new genetic syndrome. Am J Otol 1992,13:507-511.
12. Pedersen HD. Mitral Valve Prolapse in the Dog. Pathogenesis, Pathophysiology. Diagnosis and Comparative Aspects of Early Myxomatous Mitral Valve Disease. Copenhagen, Denmark: The Royal Veterinary and Agricultural University; 2000. Thesis.
13. Buchanan JW, Beardow AW, Sammarco CD. Femoral artery occlusion in Cavalier King Charles Spaniels. J Am Vet Med Assoc 1997,211.872-874
14. Karlstam E, Häggstrom J, Kvart C, et al. Pulmonary artery lesions in Cavalier King Charles Spaniels. Vet Rec 2000; 147:166-167.
15. Daniel WW. Biostatistics: A Foundation for Analysis in the Health Sciences. 5th ed. New York, NY: J Wiley; 1991:26. 528-575.
16. Nicholas FW. Veterinary Genetics. Oxford: Oxford University Press; 1987:217-231.
17. Swenson L, Haggströrn J, Kvart C, Juneja RK. Relationship between parental cardiac status in Cavalier King Charles Spaniels and prevalence and severity of chronic valvular disease in offspring. J Am Vet Med Assoc 1996;208:2009-2012.
18. Olsen LH, Fredholm M, Pedersen HD. Epidemiology and inheritance of mitral valve prolapse in Dachshunds. J Vet Intern Med 1999:13:448-456.
19. Pedersen HD, Häggstrom J, Falk T, et al. Auscultation in mild mitral regurgitation in dogs: Observer variation, effects of physical maneuvers, and agreement with color Doppler echocardiography and phonocardiography. J Vet Intern Med 1999;13:56-64.
20. Chandrasekar B, Tanguay JF. Platelets and restenosis. J Am Coll Cardiol 2000;35:555-562.
21. Pedersen HD, Mow T. Hypomagnesemia and mitral valve prolapse in Cavalier King Charles Spaniels. J Vet Med Ser A 1998;45: 607-614.