Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells

Biochemical and Biophysical Research Communications

Volumn 413, Issue 4, 2011, Pages 566-571

  Nagahama, Yu ^a,b   Obama, Takashi ^b   Usui, Michihiko ^a   Kanazawa, Yukari ^b   Iwamoto, Sanju ^c   Suzuki, Kazushige ^a   Miyazaki, Akira ^c   Yamaguchi, Tomohiro ^b   Yamamoto, Matsuo ^a   Itabe, Hiroyuki ^b  

^a Showa University Dental Hospital   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclooxygenase 2; Human gingival epithelial cells; Interleukin 8; Oxidized low density lipoprotein; Periodontitis

Indexed keywords

CD36 ANTIGEN; CYCLOOXYGENASE 2; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MICROSOME ENZYME; OXIDIZED LOW DENSITY LIPOPROTEIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANTIGEN EXPRESSION; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GINGIVA; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; KERATINOCYTE; PERIODONTITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; WESTERN BLOTTING;

ANTIGENS, CD36; CELL LINE; CHRONIC PERIODONTITIS; CYCLOOXYGENASE 2; DINOPROSTONE; GINGIVA; HUMANS; INTERLEUKIN-8; INTRAMOLECULAR OXIDOREDUCTASES; KERATINOCYTES; LIPOPROTEINS, LDL; MICROSOMES; MOUTH MUCOSA; NF-KAPPA B; UP-REGULATION;

EID: 80053578948     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.002     Document Type: Article

References (30)

1. Emingil G., Buduneli E., Aliyev A., Akilli A., Atilla G. Association between periodontal disease and acute myocardial infarction. J. Periodontol. 2000, 71:1882-1886.
2. Stein J.M., Kuch B., Conrads G., Fickl S., Chrobot J., Schulz S., Ocklenburg C., Smeets R. Clinical periodontal and microbiologic parameters in patients with acute myocardial infarction. J. Periodontol. 2009, 80:1581-1589.
3. Lösche W., Karapetow F., Pohl A., Pohl C., Kocher T. Plasma lipid and blood glucose levels in patients with destructive periodontal disease. J. Clin. Periodontol. 2000, 27:537-541.
4. Fentoĝlu Ö., Köroĝlu B.K., Hiçyi{dotless}lmaz H., Sert T., Özdem M., Sütçü R., Tamer M.N., Orhan H., Ay Z.Y., Tonguç M.Ö., Ki{dotless}rzi{dotless}oĝlu F.Y. Pro-inflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. J. Clin. Periodontol. 2011, 38:8-16.
5. Dietrich T., Jimenez M., KrallKaye E.A., Vokonas P.S., Garcia R.I. Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation 2008, 117:1668-1674.
6. Tonetti M.S., D'Aiuto F., Nibali L., Donald A., Storry C., Parkar M., Suvan J., Hingorani A.D., Vallance P., Deanfield J. Treatment of periodontitis and endothelial function. N. Engl. J. Med. 2007, 356:911-920.
7. Tamaki N., Tomofuji T., Ekuni D., Yamanaka R., Morita M. Periodontal treatment decreases plasma oxidized LDL level and oxidative stress. Clin. Oral Investig. 2010, 10.1007/s00784-010-0458-y.
8. Liu Y.C., Lerner U.H., Teng Y.T. Cytokine responses against periodontal infection Protective and destructive roles. Periodontol. 2000 2010, 52:163-206.
9. Cushing S.D., Berliner J.A., Valente A.J., Territo M.C., Navab M., Parhami F., Gerrity R., Schwartz C.J., Fogelman A.M. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc. Natl. Acad. Sci. USA 1990, 87:5134-5138.
10. Itabe H., Takeshima E., Iwasaki H., Kimura J., Yoshida Y., Imanaka T., Takano T. A monoclonal antibody against oxidized lipoprotein recognizes foam cells in atherosclerotic lesions. Complex formation of oxidized phosphatidylcholines and polypeptides. J. Biol. Chem. 1994, 269:15274-15279.
11. Itabe H., Yamamoto H., Shimamura K., Uchiyama H., Kimura J., Hata Y., Imanaka T., Takano T. Sensitive Sensitive detection of oxidatively modified low density lipoprotein using a monoclonal antibody. J. Lipid Res. 1996, 37:45-53.
12. Ehara S., Ueda M., Naruko T., Haze K., Itoh A., Otuska M., Komatsu R., Matsuo T., Itabe H., Takano T., Tsukamoto Y., Yoshiyama M., Takeuchi K., Yoshikawa J., Becker A.E. Oxidized low density lipoprotein relates to plaque destabilization in human coronary atherosclerotic lesions. Circulation 2001, 103:1955-1960.
13. Monteiro A.M., Jardini M.A., Alves S., Giampaoli V., Aubin E.C., Figueiredo Neto A.M., Gidlund M. Cardiovascular disease parameters in periodontitis. J. Periodontol. 2009, 80:378-388.
14. Sakiyama Y., Kato R., Inoue S., Suzuki K., Itabe H., Yamamoto M. Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patients. J. Periodontal Res. 2010, 45:216-222.
15. Båge T., Kats A., Lopez B.S., Morgan G., Nilsson G., Burt I., Korotkova M., Corbett L., Knox A.J., Pino L., Jakobsson P.J., Modéer T., Yucel-Lindberg T. Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation. Am. J. Pathol. 2011, 178:1676-1688.
16. 2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor. Biochem. Biophys. Res. Commun. 1999, 257:528-532.
17. Båge T., Lindberg J., Lundeberg J., Modéer T., Yucel-Lindberg T. Signal pathways JNK and NF-kappaB, identified by global gene expression profiling, are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts. BMC Genomics 2010, 11:241-257.
18. Collot-Teixeira S., Martin J., McDermott-Roe C., Poston R., McGregor J.L. CD36 and macrophages in atherosclerosis. Cardiovasc. Res. 2007, 75:468-477.
19. Wiesner P., Choi S.H., Almazan F., Benner C., Huang W., Diehl C.J., Gonen A., Butler S., Witztum J.L., Glass C.K., Miller Y.I. (2010) Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor κB and activator protein-1. Circ. Res. 2010, 107:56-65.
20. Mahanonda R., Sa-Ard-Iam N., Eksomtramate M., Rerkyen P., Phairat B., Schaecher K.E., Fukuda M.M., Pichyangkul S. Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells. J. Periodontal Res. 2009, 44:557-564.
21. Ji S., Shin J.E., Kim Y.S., Oh J.E., Min B.M., Choi Y. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun. 2009, 77:1044-1052.
22. Kanayama M., Yamaguchi S., Shibata T., Shibata N., Kobayashi M., Nagai R., Arai H., Takahashi K., Uchida K. Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal. J. Biol. Chem. 2007, 282:24166-24174.
23. Suzuki K., Sakiyama Y., Usui M., Obama T., Kato R., Itabe H., Yamamoto M. Oxidized low-density lipoproteins enhances IL-8 production in human gingival epithelial cells. J. Period Res. 2010, 45:488-495.
24. Itabe H., Mori M., Fujimoto Y., Higashi Y., Takano T. Minimally modified LDL is an oxidized LDL enriched with oxidized phosphatidylcholines. J. Biochem. 2003, 134:459-465.
25. Saegusa M., Murakami M., Nakatani Y., Yamakawa K., Katagiri M., Matsuda K., Nakamura K., Kudo I., Kawaguchi H. Contribution of membrane-associated prostaglandin E2 synthase to bone resorption. J. Cell. Physiol. 2003, 197:348-356.
26. 2 synthesis. Int. J. Mol. Med. 2004, 14:353-359.
27. Zhao J., Qi R., Li R., Wu W., Gao X., Bao L., Lu S. Protective effects of aspirin against oxidized LDL-induced inflammatory protein expression in human endothelial cells. J. Cardiovasc. Pharmacol. 2008, 5:32-37.
28. Pontsler A.V., St Hilaire A., Marathe G.K., Zimmerman G.A., McIntyre T.M. Cyclooxygenase-2 is induced in monocytes by peroxisome proliferator activated receptor gamma and oxidized alkyl phospholipids from oxidized low density lipoprotein. J. Biol. Chem. 2002, 277:13029-13036.
29. Hamilton T.A., Major J.A., Chisolm G.M. The effects of oxidized low density lipoproteins on inducible mouse macrophage gene expression are gene and stimulus dependent. J. Clin. Invest. 1995, 95:2020-2027.
30. Ohlsson B.G., Englund M.C., Karlsson A.L., Knutsen E., Erixon C., Skribeck H., Liu Y., Bondjers G., Wiklund O. Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-kappaB to DNA and the subsequent expression of tumor necrosis factor-alpha and interleukin-1beta in macrophages. J. Clin. Invest. 1996, 98:78-89.