Synthesis and biological evaluation of sugar-derived chiral nitroimidazoles as potential antimycobacterial agents

Carbohydrate Research

Volumn 346, Issue 13, 2011, Pages 1760-1766

  Mugunthan, G ^a   Sriram, Dharmarajan ^b   Yogeeswari, Perumal ^b   Kartha, K P Ravindranathan ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Antimycobacterial agents; Carbohydrates; Chiral pool; Nitroimidazoles

Indexed keywords

CARBOHYDRATES; SYNTHESIS (CHEMICAL);

ANTI-MYCOBACTERIAL; BIOLOGICAL EVALUATION; CHIRAL POOL; MYCOBACTERIUM TUBERCULOSIS; NITROIMIDAZOLES;

ORGANIC COMPOUNDS;

1,2:3,6 DIANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 THIO DEXTRO GLUCITOL; 1,2:3,6 DIANHYDRO 4,5 O ISOPROPYLIDENE DEXTRO GLUCITOL; 1,2:3,6 DIANHYDRO 4,5 O ISOPROPYLIDENE DEXTRO MANNITOL; 2,3 DIHYDRO (1',2' O ISOPROPYLIDENE 3' O METHYL BETA LEVO THREOFURANOS 4' YL) 6 NITROIMIDAZO[2,1 B]OXAZOLE; 2,3 DIHYDRO (2',3' O ISOPROPYLIDENE ALPHA DEXTRO ERYTHROFURANOSYL) 6 NITROIMIDAZO[2,1 B]OXAZOLE; 2,3 DIHYDRO (2',3' O ISOPROPYLIDENE ALPHA DEXTRO ERYTHROFURANOSYL) 6 NITROIMIDAZO[2,1 B]THIAZOLE; 3,6 ANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 [N (2 METHYL 4 NITROIMIDAZOLO)] DEXTRO GLUCITOL; 3,6 ANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 [N (2 NITROIMIDAZOLO)] DEXTRO GLUCITOL; 3,6 ANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 [N (2 NITROIMIDAZOLO)] DEXTRO MANNITOL; 3,6 ANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 [N (2,4 DINITROIMIDAZOLO)] DEXTRO GLUCITOL; 3,6 ANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 [N (4 NITROIMIDAZOLO)] DEXTRO GLUCITOL; 3,6 ANHYDRO 1 DEOXY 4,5 O ISOPROPYLIDENE 1 [N (4 NITROIMIDAZOLO)] DEXTRO MANNITOL; 6 DEOXY 1,2 O ISOPROPYLIDENE 3 O METHYL 6 [N (4 NITROIMIDAZOLO)] ALPHA DEXTRO GLUCOFURANOSE; 6,7 DIHYDRO 2 NITRO 6 (4 TRIFLUOROMETHOXYBENZYLOXY) 5H IMIDAZO[2,1 B][1,3]OXAZINE; ANTIMYCOBACTERIAL AGENT; CARBOHYDRATE DERIVATIVE; DELAMANID; ETHAMBUTOL; ISONIAZID; NITROIMIDAZOLE DERIVATIVE; RIFAMPICIN; SUGAR; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBOHYDRATE SYNTHESIS; CHIRALITY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

MYCOBACTERIUM TUBERCULOSIS H37RV;

EID: 80053576472     PISSN: 00086215     EISSN: 1873426X     Source Type: Journal    
DOI: 10.1016/j.carres.2011.05.034     Document Type: Article

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