Evaluation and management of acute menorrhagia in women with and without underlying bleeding disorders: Consensus from an international expert panel

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 158, Issue 2, 2011, Pages 124-134

  James, Andra H ^a   Kouides, Peter A ^b   Abdul Kadir, Rezan ^c   Dietrich, Jennifer E ^d   Edlund, Mans ^e   Federici, Augusto B ^f   Halimeh, Susan ^g   Kamphuisen, Pieter Willem ^h   Lee, Christine A ⁱ   Martínez Perez, Oscar ^j   McLintock, Claire ^k   Peyvandi, Flora ^l   Philipp, Claire ^m   Wilkinson, Jeffrey ^a   Winikoff, Rochelle ⁿ  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b ROCHESTER GENERAL HOSPITAL   (United States)

^c ROYAL FREE HOSPITAL   (United Kingdom)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e DANDERYD HOSPITAL   (Sweden)

^f UNIVERSITY OF MILAN   (Italy)

^g Centre for Coagulation Disorders Rhine Ruhr Area   (Germany)

^h ACADEMIC MEDICAL CENTER   (Netherlands)

ⁱ UNIVERSITY OF LONDON   (United Kingdom)

^j HOSPITAL UNIVERSITARIO FUNDACIÓN JIMÉNEZ DÍAZ   (Spain)

^k AUCKLAND CITY HOSPITAL   (New Zealand)

^l FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^m ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

ⁿ UNIVERSITY OF MONTREAL   (Canada)

more..

Author keywords

Acute menorrhagia; Bleeding disorder; Coagulation factor; Consensus; Hemostasis management

Indexed keywords

AMINOCAPROIC ACID; CONJUGATED ESTROGEN; DESMOPRESSIN; LEVONORGESTREL; MEDROXYPROGESTERONE; MEDROXYPROGESTERONE ACETATE; NORETHISTERONE ACETATE; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID;

ACUTE MENORRHAGIA; ANOVULATION; ANTICOAGULANT THERAPY; BLEEDING DISORDER; CONSENSUS; CURETTAGE; EMERGENCY CARE; ENDOMETRIUM ABLATION; ENDOMETRIUM POLYP; HEALTH CARE PERSONNEL; HORMONAL THERAPY; HUMAN; HYPOTHYROIDISM; HYSTERECTOMY; HYSTEROSCOPY; LEUKEMIA; MAINTENANCE THERAPY; MENORRHAGIA; MYOMECTOMY; PATIENT CARE; POLYPECTOMY; POSTOPERATIVE COMPLICATION; PREDICTION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; THROMBOCYTE DYSFUNCTION; THROMBOCYTE TRANSFUSION; THROMBOCYTOPATHY; THROMBOCYTOPENIA; THROMBOSIS; UTERINE ARTERY EMBOLIZATION; VON WILLEBRAND DISEASE;

EID: 80053575539     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2011.04.025     Document Type: Review

References (77)

1. R.W. Shaw, M.R. Brickley, L. Evans, and M.J. Edwards Perceptions of women on the impact of menorrhagia on their health using multi-attribute utility assessment Br J Obstet Gynaecol 105 1998 1155 1159 (Pubitemid 28526197)
2. M. Shankar, C. Chi, and R.A. Kadir Review of quality of life: menorrhagia in women with or without inherited bleeding disorders Haemophilia 14 2008 15 20
3. P.E. Warner, H.O. Critchley, M.A. Lumsden, M. Campbell-Brown, A. Douglas, and G.D. Murray Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data Am J Obstet Gynecol 190 2004 1216 1223 (Pubitemid 38692200)
4. A.H. James, P.A. Kouides, R. Abdul-Kadir, M. Edlund, A.B. Federici, and S. Halimeh Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert panel Am J Obstet Gynecol 201 12 2009 e1 e8
5. C.A. Lee Women and inherited bleeding disorders: menstrual issues Semin Hematol 36 1999 21 27 (Pubitemid 29463583)
6. M. Shankar, C.A. Lee, C.A. Sabin, D.L. Economides, and R.A. Kadir von Willebrand disease in women with menorrhagia: a systematic review BJOG 111 2004 734 740 (Pubitemid 38869763)
7. E.A. Claessens, and C.A. Cowell Acute adolescent menorrhagia Am J Obstet Gynecol 139 1981 277 280 (Pubitemid 11191113)
8. G.R. DeVore, O. Owens, and N. Kase Use of intravenous Premarin in the treatment of dysfunctional uterine bleeding - a double-blind randomized control study Obstet Gynecol 59 1982 285 291 (Pubitemid 12176943)
9. J.S. Purcell, and A.C. Hergenroeder Severe Menorrhagia Adolesc Med 7 1996 449 454
10. R.A. Kadir, D.L. Economides, C.A. Sabin, D. Owens, and C.A. Lee Frequency of inherited bleeding disorders in women with menorrhagia Lancet 351 1998 485 489 (Pubitemid 28070095)
11. S.M. McKinlay, D.J. Brambilla, and J.G. Posner The normal menopause transition Maturitas 61 2008 4 16
12. R.A. Kadir, D.L. Economides, C.A. Sabin, D. Pollard, and C.A. Lee Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders Haemophilia 5 1999 40 48 (Pubitemid 29094902)
13. P.A. Kouides, P.D. Phatak, P. Burkart, C. Braggins, C. Cox, and Z. Bernstein Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient survey Haemophilia 6 2000 643 648
14. M.V. Ragni, F.A. Bontempo, and A.C. Hassett von Willebrand disease and bleeding in women Haemophilia 5 1999 313 317 (Pubitemid 29495707)
15. A.H. James More than menorrhagia: a review of the obstetric and gynaecological manifestations of bleeding disorders Haemophilia 11 2005 295 307 (Pubitemid 41030828)
16. A.S. Lukes, R.A. Kadir, F. Peyvandi, and P.A. Kouides Disorders of hemostasis and excessive menstrual bleeding: prevalence and clinical impact Fertil Steril 84 2005 1338 1344 (Pubitemid 41571879)
17. J.A. Bevan, K.W. Maloney, C.A. Hillery, J.C. Gill, R.R. Montgomery, and J.P. Scott Bleeding disorders: a common cause of menorrhagia in adolescents J Pediatr 138 2001 856 861 (Pubitemid 32545587)
18. J.A. Lopez, R.K. Andrews, V. Afshar-Kharghan, and M.C. Berndt Bernard-Soulier syndrome Blood 91 1998 4397 4418 (Pubitemid 28270285)
19. O. Markovitch, M. Ellis, M. Holzinger, S. Goldberger, and Y. Beyth Severe juvenile vaginal bleeding due to Glanzmann's thrombasthenia: case report and review of the literature Am J Hematol 57 1998 225 227 (Pubitemid 28139240)
20. M. Vijapurkar, L. Mota, S. Shetty, and K. Ghosh Menorrhagia and reproductive health in rare bleeding disorders: a study from the Indian subcontinent Haemophilia 15 2009 199 202
21. E.D. Levens, P. Scheinberg, and A.H. DeCherney Severe menorrhagia associated with thrombocytopenia Obstet Gynecol 110 2007 913 917 (Pubitemid 47508759)
22. M. Berger, and L.F. Brass Severe thrombocytopenia in iron deficiency anemia Am J Hematol 24 1987 425 428 (Pubitemid 17059840)
23. E.A. Claessens, and C.A. Cowell Dysfunctional uterine bleeding in the adolescent Pediatr Clin North Am 28 1981 369 378 (Pubitemid 11087156)
24. C.S. Philipp, A. Dilley, C.H. Miller, B. Evatt, A. Baranwal, and R. Schwartz Platelet functional defects in women with unexplained menorrhagia J Thromb Haemost 1 2003 477 484
25. C.S. Philipp, A. Faiz, N. Dowling, A. Dilley, L.A. Michaels, and C. Ayers Age and the prevalence of bleeding disorders in women with menorrhagia Obstet Gynecol 105 2005 61 66 (Pubitemid 40189912)
26. J.W. Ely, C.M. Kennedy, E.C. Clark, and N.C. Bowdler Abnormal uterine bleeding: a management algorithm J Am Board Fam Med 19 2006 590 602 (Pubitemid 44736814)
27. S. Perlman, S. Nakajima, and S. Hertweck Clinical protocols in pediatric and adolescent gynecology: Informa 2004
28. T. Tulandi, and K. Salamah Fertility and uterine artery embolization Obstet Gynecol 115 2010 857 860
29. H. Husted, L. Blond, S. Sonne-Holm, G. Holm, T.W. Jacobsen, and P. Gebuhr Tranexamic acid reduces blood loss and blood transfusions in primary total hip arthroplasty: a prospective randomized double-blind study in 40 patients Acta Orthop Scand 74 2003 665 669 (Pubitemid 38067866)
30. A. Lethaby, C. Farquhar, and I. Cooke Antifibrinolytics for heavy menstrual bleeding Cochrane Database Syst Rev 2000 CD000249
31. M. Lozano, M. Basora, L. Peidro, I. Merino, J.M. Segur, and A. Pereira Effectiveness and safety of tranexamic acid administration during total knee arthroplasty Vox Sang 95 2008 39 44 (Pubitemid 351799410)
32. H. Mohri High dose of tranexamic acid for treatment of severe menorrhagia in patients with von Willebrand disease J Thromb Thrombolysis 14 2002 255 257 (Pubitemid 37069310)
33. A. Lukes, J. Gersten, G. Shangold, D. Patrick, and K. Moore A novel, oral tranexamic acid formulation for heavy menstrual bleeding: effect on quality of life 2010 American College of Obstetrics and Gynecology
34. Y. Hamani, I. Ben-Shachar, Y. Kalish, and S. Porat Intrauterine balloon tamponade as a treatment for immune thrombocytopenic purpura-induced severe uterine bleeding Fertil Steril 8 2010 [Epub June]
35. C.W. Bowkley, G.J. Dubel, R.A. Haas, G.M. Soares, and S.H. Ahn Uterine artery embolization for control of life-threatening hemorrhage at menarche: brief report J Vasc Interv Radiol 18 2007 127 131 (Pubitemid 46616668)
36. S. Vedantham, S.C. Goodwin, B. McLucas, and G. Mohr Uterine artery embolization: an underused method of controlling pelvic hemorrhage Am J Obstet Gynecol 176 1997 938 948 (Pubitemid 27202959)
37. K. Firouznia, H. Ghanaati, M. Sanaati, A.H. Jalali, and M. Shakiba Pregnancy after uterine artery embolization for symptomatic fibroids: a series of 15 pregnancies AJR Am J Roentgenol 192 2009 1588 1592
38. S. Yeasmin, K. Nakayama, M. Ishibashi, A. Katagiri, K. Iida, and N. Nakayama Microwave endometrial ablation as an alternative to hysterectomy for the emergent control of uterine bleeding in patients who are poor surgical candidates Arch Gynecol Obstet 280 2009 279 282
39. American College of Obstetricians and Gynecologists Endometrial ablation ACOG Pract Bull 2007 81
40. C. Nichols, and E. Gill Thermal balloon endometrial ablation for management of acute uterine hemorrhage Am Coll Obstet Gynecol 100 2002 1092 1094 (Pubitemid 35341363)
41. Winikoff R. Unpublished observation.
42. G. Wunder, D. Francoeur, S. Gascon, and R. Winikoff Has the introduction of a standardized treatment protocol changed the management and outcome of acute severe adolescent menorrhagia? Thromb Res 123 Suppl. 2 2009 S150
43. M. Edlund, M. Blomback, and G. Fried Desmopressin in the treatment of menorrhagia in women with no common coagulation factor deficiency but with prolonged bleeding time Blood Coagul Fibrinolysis 13 2002 225 231 (Pubitemid 35001888)
44. A.B. Federici, G. Castaman, A. Thompson, and E. Berntorp von Willebrand's disease: clinical management Haemophilia 12 Suppl. 3 2006 152 158
45. Kouides PA. Personal communication, 2009.
46. P.A. Kouides, V.R. Byams, C.S. Philipp, S.F. Stein, J.A. Heit, and A.S. Lukes Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid Br J Haematol 145 2009 212 220
47. B. Godeau, D. Provan, and J. Bussel Immune thrombocytopenic purpura in adults Curr Opin Hematol 14 2007 535 556 (Pubitemid 47457646)
48. D. Meirow, J. Rabinovici, D. Katz, R. Or, Y. Shufaro, and D. Ben-Yehuda Prevention of severe menorrhagia in oncology patients with treatment-induced thrombocytopenia by luteinizing hormone-releasing hormone agonist and depo-medroxyprogesterone acetate Cancer 107 2006 1634 1641 (Pubitemid 44546925)
49. A.T. Nurden Glanzmann thrombasthenia Orphanet J Rare Dis 1 2006 10
50. M.C. Ozelo, P. Svirin, and L. Larina Use of recombinant factor VIIa in the management of severe bleeding episodes in patients with Bernard-Soulier syndrome Ann Hematol 84 2005 816 822 (Pubitemid 43008557)
51. D.M. DiMichele, and W.E. Hathaway Use of DDAVP in inherited and acquired platelet dysfunction Am J Hematol 33 1990 39 45 (Pubitemid 20031291)
52. B. Vigue Bench-to-bedside review: optimising emergency reversal of vitamin K antagonists in severe haemorrhage - from theory to practice Crit Care 13 2009 209
53. U. Kalina, H. Bickhard, and S. Schulte Biochemical comparison of seven commercially available prothrombin complex concentrates Int J Clin Pract 62 2008 1614 1622
54. J.H. Levy, K.A. Tanaka, and W. Dietrich Perioperative hemostatic management of patients treated with vitamin K antagonists Anesthesiology 109 2008 918 926
55. J. Bux Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion Vox Sang 89 2005 1 10 (Pubitemid 40839544)
56. K. Bennett, M.L. Daley, and C. Pike Factor V deficiency and menstruation: a gynecologic challenge Obstet Gynecol 89 1997 839 840 (Pubitemid 27184820)
57. E. Dupuy, C. Soria, P. Molho, J.M. Zini, S. Rosenstingl, and C. Laurian Embolized ischemic lesions of toes in an afibrinogenemic patient: possible relevance to in vivo circulating thrombin Thromb Res 102 2001 211 219 (Pubitemid 32441709)
58. J. Ansell, J. Hirsh, E. Hylek, A. Jacobson, M. Crowther, and G. Palareti Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 160S 198S (Pubitemid 351892967)
59. D.R. Spahn, V. Cerny, T.J. Coats, J. Duranteau, E. Fernandez-Mondejar, and G. Gordini Management of bleeding following major trauma: a European guideline Crit Care 11 2007 R17
60. B. Leithauser, D. Zielske, U.T. Seyfert, and F. Jung Effects of desmopressin on platelet membrane glycoproteins and platelet aggregation in volunteers on clopidogrel Clin Hemorheol Microcirc 39 2008 293 302 (Pubitemid 352040007)
61. M. Cattaneo Desmopressin in the treatment of patients with defects of platelet function Haematologica 87 2002 1122 1124 (Pubitemid 35397767)
62. G. Vilahur, B.G. Choi, M.U. Zafar, J.F. Viles-Gonzalez, D.A. Vorchheimer, and V. Fuster Normalization of platelet reactivity in clopidogrel-treated subjects J Thromb Haemost 5 2007 82 90 (Pubitemid 44921071)
63. C. Kearon, S.R. Kahn, G. Agnelli, S. Goldhaber, G.E. Raskob, and A.J. Comerota Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 454S 545S (Pubitemid 351892971)
64. M. Bohm, S. Taschner, E. Kretzschmar, R. Gerlach, E.J. Favaloro, and I. Scharrer Cold storage of citrated whole blood induces drastic time-dependent losses in factor VIII and von Willebrand factor: potential for misdiagnosis of haemophilia and von Willebrand disease Blood Coagul Fibrinolysis 17 2006 39 45 (Pubitemid 43170753)
65. R.A. Lipton Misdiagnosis by milk box Haemophilia 9 2003 235
66. W.L. Nichols, M.B. Hultin, A.H. James, M.J. Manco-Johnson, R.R. Montgomery, and T.L. Ortel von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) Haemophilia 14 2008 171 232 (Pubitemid 351343618)
67. R.A. Kadir, D.L. Economides, C.A. Sabin, D. Owens, and C.A. Lee Variations in coagulation factors in women: effects of age, ethnicity, menstrual cycle and combined oral contraceptive Thromb Haemost 82 1999 1456 1461 (Pubitemid 29527639)
68. Prescribing information for LYSTEDA. Available at http://www.xanodyne. com/pdf/Lysteda.pdf. Available from: http://www.xanodyne.com/pdf/Lysteda.pdf [accessed 7 May].
69. Y.C. Chen, T.Y. Chao, S.N. Cheng, S.H. Hu, and J.Y. Liu Prevalence of von Willebrand disease in women with iron deficiency anaemia and menorrhagia in Taiwan Haemophilia 14 2008 768 774
70. S. Gupta, J. Jose, and I. Manyonda Clinical presentation of fibroids Best Pract Res Clin Obstet Gynaecol 22 2008 615 626 (Pubitemid 351804119)
71. M. Palep-Singh, and A. Prentice Epidemiology of abnormal uterine bleeding Best Pract Res Clin Obstet Gynaecol 21 2007 887 890 (Pubitemid 350177601)
72. I.S. Fraser, R.J. Porte, P.A. Kouides, and A.S. Lukes A benefit-risk review of systemic haemostatic agents: part 2: in excessive or heavy menstrual bleeding Drug Saf 31 2008 275 282 (Pubitemid 351441576)
73. C.O. Chigbu, and G.C. Iloabachie Intrauterine Foley urethral catheter for postmyomectomy uterine bleeding Int J Gynaecol Obstet 95 2006 175 176 (Pubitemid 44635507)
74. C. Georgiou Balloon tamponade in the management of postpartum haemorrhage: a review BJOG 116 2009 748 757
75. V.A. Hurley, and N.A. Beischer Cervical pregnancy: hysterectomy avoided with the use of a large Foley catheter balloon Aust N Z J Obstet Gynaecol 28 1988 230 232
76. J.T. Phelan 2nd, J. Broder, and P.A. Kouides Near-fatal uterine hemorrhage during induction chemotherapy for acute myeloid leukemia: a case report of bilateral uterine artery embolization Am J Hematol 77 2004 151 155 (Pubitemid 39281860)
77. B. Vidarsson, and P.T. Onundarson Recombinant factor VIIa for bleeding in refractory thrombocytopenia Thromb Haemost 83 2000 634 635 (Pubitemid 30201148)