Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype

Annals of the Rheumatic Diseases

Volumn 70, Issue 11, 2011, Pages 2044-2048

  Hindryckx, P ^a   Laukens, D ^a   Serry, G ^a   Van Praet, L ^a   Cuvelier, C ^a   Mielants, H ^a   Peeters, H ^a   Elewaut, D ^a   De Vos, M ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; PLACENTAL GROWTH FACTOR; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A;

ANGIOGENESIS; ARTICLE; CELL SUBPOPULATION; CELL TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; CROHN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENT CELL; INFLAMMATION; INTESTINE BIOPSY; INTESTINE MUCOSA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RHEUMATOID ARTHRITIS; SPONDYLOARTHROPATHY; STAINING; SYNOVITIS; TISSUE DISTRIBUTION;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; COLITIS; CROHN DISEASE; ENDOTHELIUM, VASCULAR; HUMANS; ILEITIS; INTESTINAL MUCOSA; NEOVASCULARIZATION, PATHOLOGIC; PREGNANCY PROTEINS; SPONDYLARTHRITIS; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80053568996     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.149229     Document Type: Article

References (20)

1. De Vos M. Joint involvement in inflammatory bowel disease: managing inflammation outside the digestive system. Expert Rev Gastroenterol Hepatol 2010;4:81-9.
2. Kidd BL, Moore K, Walters MT, et al. Immunohistological features of synovitis in ankylosing spondylitis: a comparison with rheumatoid arthritis. Ann Rheum Dis 1989;48:92-8. (Pubitemid 19062224)
3. Danese S, Sans M, De la Motte C, et al. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 2006;130:2060-73. (Pubitemid 43816964)
4. Drouart M, Saas P, Billot M, et al. High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies. Clin Exp Immunol 2003;132:158-62. (Pubitemid 36418919)
5. Tsiolakidou G, Koutroubakis IE, Tzardi M, et al. Increased expression of VEGF and CD146 in patients with inflammatory bowel disease. Dig Liver Dis 2008;40:673-9.
6. Griga T, May B, Pfisterer O, et al. Immunohistochemical localization of vascular endothelial growth factor in colonic mucosa of patients with inflammatory bowel disease. Hepatogastroenterology 2002;49:116-23. (Pubitemid 34289498)
7. Scaldaferri F, Vetrano S, Sans M, et al. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology 2009;136:585-95.e5.
8. Kim I, Moon SO, Kim SH, et al. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem 2001;276:7614-20.
9. Carmeliet P, Moons L, Luttun A, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 2001;7:575-83. (Pubitemid 32448325)
10. Jacques P, Elewaut D. Joint expedition: linking gut inflammation to arthritis. Mucosal Immunol 2008;1:364-71.
11. Baeten D, Demetter P, Cuvelier CA, et al. Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy. J Pathol 2002;196:343-50. (Pubitemid 34189425)
12. May E, Märker-Hermann E, Wittig BM, et al. Identical T-cell expansions in the colon mucosa and the synovium of a patient with enterogenic spondyloarthropathy. Gastroenterology 2000;119:1745-55. (Pubitemid 32198700)
13. Rudwaleit M, van der Heijde D, Landewé R, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 2011;70:25-31.
14. Russo P. The pathology of chronic inflammatory bowel disease. In: Russo P, ed. Pediatric Inflammatory Bowel Disease. Philadelphia, PA: Springer, 2007:241-62.
15. Ong CW, Kim LG, Kong HH, et al. Computer-assisted pathological immunohistochemistry scoring is more time-effective than conventional scoring, but provides no analytical advantage. Histopathology 2010;56:523-9.
16. Vermeulen PB, Gasparini G, Fox SB, et al. Quantification of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 1996;32A:2474-84.
17. Hoeben A, Landuyt B, Highley MS, et al. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004;56:549-80. (Pubitemid 39658463)
18. Luttun A, Tjwa M, Carmeliet P. Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders. Ann NY Acad Sci 2002;979:80-93. (Pubitemid 36121141)
19. Ciccia F, Accardo-Palumbo A, Giardina A, et al. Expansion of intestinal CD4+CD25(high) Treg cells in patients with ankylosing spondylitis: a putative role for interleukin-10 in preventing intestinal Th17 response. Arthritis Rheum 2010;62:3625-34.
20. Ciccia F, Bombardieri M, Rizzo A, et al. Over-expression of paneth cell-derived antimicrobial peptides in the gut of patients with ankylosing spondylitis and subclinical intestinal inflammation. Rheumatology (Oxford) 2010;49:2076-83.