CXCL13 chemokine in pediatric and adult neuroborreliosis

Acta Neurologica Scandinavica

Volumn 124, Issue 5, 2011, Pages 321-328

  Wutte, N ^a   Berghold, A ^a   Loffler S ^a   Zenz, W ^a   Daghofer, E ^a   Krainberger, I ^a   Kleinert, G ^a   Aberer, E ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

CXCL13 in children; CXCL13 in serum; Diagnosis; Neuroborreliosis

Indexed keywords

CXCL13 CHEMOKINE;

ADULT DISEASE; ARTICLE; ASEPTIC MENINGITIS; BACTERIAL MENINGITIS; CELL COUNT; CHILDHOOD DISEASE; CONTROLLED STUDY; EARLY DIAGNOSIS; FACIAL NERVE PARALYSIS; HUMAN; LUMBAR PUNCTURE; LYME DISEASE; NEUROSYPHILIS; PLEOCYTOSIS; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL;

ADOLESCENT; ADULT; AGE FACTORS; CHEMOKINE CXCL13; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LYME NEUROBORRELIOSIS; MALE; MIDDLE AGED; UP-REGULATION; YOUNG ADULT;

EID: 80053566223     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2010.01477.x     Document Type: Article

References (29)

1. Kaiser R. Neuroborreliosis. J Neurol 1998;245:247-55.
2. Pachner AR, Steere AC. The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis. Neurology 1985;35:47-53.
3. Oschmann P, Dorndorf W, Hornig C, Schafer C, Wellensiek HJ, Pflughaupt KW. Stages and syndromes of neuroborreliosis. J Neurol 1998;245:262-72.
4. Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. Diagnosis of Lyme borreliosis. Clin Microbiol Rev 2005;18:484-509.
5. Pfister HW, Rupprecht TA. Clinical aspects of neuroborreliosis and post-Lyme disease syndrome in adult patients. Int J Med Microbiol 2006;296:11-6.
6. Mygland A, Ljostad U, Fingerle V, Rupprecht T, Schmutzhard E, Steiner I. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 2010;17:8-16.
7. Wilske B, Schierz G, Preac-Mursic V et al. Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarth's syndrome). J Infect Dis 1986;153:304-14.
8. Wilske B, Bader L, Pfister HW, Preac-Mursic V. Diagnosis of Lyme neuroborreliosis. Detection of intrathecal antibody formation. Fortschr Med 1991;109:441-6.
9. Ljostad U, Skarpaas T, Mygland A. Clinical usefulness of intrathecal antibody testing in acute Lyme neuroborreliosis. Eur J Neurol 2007;14:873-6.
10. Hansen K, Lebech AM. Lyme neuroborreliosis: a new sensitive diagnostic assay for intrathecal synthesis of Borrelia burgdorferi- specific immunoglobulin G, A, and M. Ann Neurol 1991;30:197-205.
11. Reiber H, Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem 1991;37:1153-60.
12. Blanc F, Jaulhac B, Fleury M et al. Relevance of the antibody index to diagnose Lyme neuroborreliosis among seropositive patients. Neurology 2007;69:953-8.
13. Oschmann P, Wellensiek HJ, Zhong W, Dorndorf W, Pflughaupt KW. Relationship between the Borrelia burgdorferi specific immune response and different stages and syndromes in neuroborreliosis. Infection 1997;25:292-7.
14. Schutzer SE, Coyle PK, Krupp LB et al. Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease. J Clin Invest 1997;100:763-7.
15. Rupprecht TA, Pfister HW, Angele B, Kastenbauer S, Wilske B, Koedel U. The chemokine CXCL13 (BLC): a putative diagnostic marker for neuroborreliosis. Neurology 2005;65:448-50.
16. Rupprecht TA, Koedel U, Angele B, Fingerle V, Pfister HW. [Cytokine CXCL13 - a possible early CSF marker for neuroborreliosis]. Nervenarzt 2006;77:470-3.
17. Segal BM, Logigian EL. Sublime diagnosis of Lyme neuroborreliosis. Neurology 2005;65:351-2.
18. Ljostad U, Mygland A. CSF B-lymphocyte chemoattractant (CXCL13) in the early diagnosis of acute Lyme neuroborreliosis. J Neurol 2008;255:732-7.
19. Senel M, Rupprecht TA, Tumani H, Pfister HW, Ludolph AC, Brettschneider J. The chemokine CXCL13 in acute neuroborreliosis. J Neurol Neurosurg Psychiatry 2010;81:929-33.
20. Narayan K, Dail D, Li L et al. The nervous system as ectopic germinal center: CXCL13 and IgG in Lyme neuroborreliosis. Ann Neurol 2005;57:813-23.
21. Rupprecht TA, Kirschning CJ, Popp B et al. Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2. Infect Immun 2007;75:4351-6.
22. Steinmetz H. Leitlinien für Diagnostik und Therapie in der Neurologie; 4. überarbeitete Auflage 2008, S. 654 ff, ISBN 978-3-13-132414-6; Stuttgart: Georg Thieme Verlag.
23. Nyman D, Jansson C, Carlsson S, Johansson C, Nyberg C. Chemokine CXCL13 in cerebrospinal fluid (CSF) as marker of disease activity in neuroborreliosis (NB). 11th international congress on Lyme borreliosis and other tick-borne diseases, Irvine Oct 19-22, 2008
24. Rupprecht TA, Schmidt C, Plate A et al. ProCL - a prospective study on the diagnostic role of CXCL13 in acute Lyme Neuroborreliosis. Oral presentation at the 12th international congress on Lyme borreliosis and other tick-borne diseases, Ljubljana September 26-29, 2010.
25. Zbinden R, Goldenberger D, Lucchini GM, Altwegg M. Comparison of two methods for detecting intrathecal synthesis of Borrelia burgdorferi-specific antibodies and PCR for diagnosis of Lyme neuroborreliosis. J Clin Microbiol 1994;32:1795-8.
26. Van Burgel ND, Bakles F, Brandenburg A, Kroes ACM, Van Dam AP. CXCL13 in CSF for diagnosing Lyme neuroborreliosis. 12th international congress on Lyme borreliosis and other tick-borne diseases, Ljubljana September 26-29, 2010
27. Krumbholz M, Theil D, Cepok M et al. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006;129:200-11.
28. Bürkle A, Niedermeier M, Schmitt-Graff A, Wierda WG, Keating MJ, Burger JA. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13, in B-cell chronic lymhocytic leukemia. Blood 2007;110:3316-25.
29. Rupprecht TA, Plate A, Adam M et al. The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute lyme neuroborreliosis. J Neuroinflammation 2009;6:42.