THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling

Modern Pathology

Volumn 24, Issue 10, 2011, Pages 1390-1403

  Förster, Susann ^a   Gretschel, Stephan ^b   Jöns, Thomas ^b   Yashiro, Masakazu ^c   Kemmner, Wolfgang ^a  

^a Experimental and Clinical Research Center   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

cancer associated fibroblasts; gastric adenocarcinoma; gene expression profiling; Laur n classification; tumor stroma

Indexed keywords

THROMBOSPONDIN; THROMBOSPONDIN 4; UNCLASSIFIED DRUG;

ARTICLE; CANCER INVASION; CELL DENSITY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENETIC ANALYSIS; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STOMACH ADENOCARCINOMA;

EID: 80053562076     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.99     Document Type: Article

References (55)

1. Siewert JR, Bottcher K, Stein HJ, et al. Relevant prognostic factors in gastric cancer: ten-year results of the German Gastric Cancer Study. Ann Surg 1998;228:449-461. (Pubitemid 30194389)
2. Hundahl SA, Phillips JL, Menck HR. The National Cancer Data Base Report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy: Fifth Edition American Joint Committee on Cancer staging, proximal disease, and the 'different disease' hypothesis. Cancer 2000;88:921-932. (Pubitemid 30091113)
3. Dicken BJ, Bigam DL, Cass C, et al. Gastric adenocarcinoma: review and considerations for future directions. Ann Surg 2005;241:27-39. (Pubitemid 40044837)
4. Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-697.
5. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965;64:31-49.
6. Day DW, Jass JR, Price AB, et al. Epithelial tumours of the stomach. In: Day DW, Morson BC (eds). Morson and Dawson's Gastrointestinal Pathology, 4th edn. Blackwell Science: Malden, Massachusetts, USA, 2003, pp 162-195.
7. Werner M, Becker KF, Keller G, et al. Gastric adenocarcinoma: pathomorphology and molecular pathology. J Cancer Res Clin Oncol 2001;127:207-216.
8. Vauhkonen M, Vauhkonen H, Sipponen P. Pathology and molecular biology of gastric cancer. Best Pract Res Clin Gastroenterol 2006;20:651-674. (Pubitemid 44418021)
9. Roukos D, Agnantis N, Fatouros M, et al. Gastric cancer: introduction, pathology, epidemiology. Gastric Breast Cancer 2002;1:1-3.
10. Boussioutas A, Li H, Liu J, et al. Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res 2003;63:2569-2577. (Pubitemid 36605198)
11. Jinawath N, Furukawa Y, Hasegawa S, et al. Comparison of gene-expression profiles between diffuse-and intestinal-type gastric cancers using a genome-wide cDNA microarray. Oncogene 2004;23:6830-6844. (Pubitemid 39280016)
12. Kim B, Bang S, Lee S, et al. Expression profiling and subtype-specific expression of stomach cancer. Cancer Res 2003;63:8248-8255. (Pubitemid 37549475)
13. Wu CM, Lee YS, Wang TH, et al. Identification of differential gene expression between intestinal and diffuse gastric cancer using cDNA microarray. Oncol Rep 2006;15:57-64.
14. Hippo Y, Taniguchi H, Tsutsumi S, et al. Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Res 2002;62:233-240. (Pubitemid 34074010)
15. Ribeiro MM, Sarmento JA, Sobrinho Simoes MA, et al. Prognostic significance of Lauren and Ming classifications and other pathologic parameters in gastric carcinoma. Cancer 1981;47:780-784. (Pubitemid 11135877)
16. Stemmermann GN, Brown C. A survival study of intestinal and diffuse types of gastric carcinoma. Cancer 1974;33:1190-1195.
17. Henson DE, Dittus C, Younes M, et al. Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973-2000: increase in the signet ring cell type. Arch Pathol Lab Med 2004;128:765-770. (Pubitemid 38856886)
18. Lauren PA, Nevalainen TJ. Epidemiology of intestinal and diffuse types of gastric carcinoma. A time-trend study in Finland with comparison between studies from high-and low-risk areas. Cancer 1993;71: 2926-2933. (Pubitemid 23145518)
19. Arias AM. Epithelial mesenchymal interactions in cancer and development. Cell 2001;105:425-431. (Pubitemid 32520849)
20. Matrisian LM, Cunha GR, Mohla S. Epithelial-stromal interactions and tumor progression: meeting summary and future directions. Cancer Res 2001;61:3844-3846. (Pubitemid 32695002)
21. Fenoglio-Preiser C, Carneiro F, Correa P, et al. Tumours of the stomach. In: Hamilton SR, Aaltonen LA (eds). Pathology and Genetics of Tumours of the Digestive System. 3 edn., Vol. 2, IARC Press: Lyon, 2000, pp 37-67.
22. Watanabe H, Jass JR, Sobin LH. Histological classification of gastric tumours. In: Watanabe H, Jass JR, Sobin LH (eds). Histological Typing of Oesophageal and Gastric Tumours, 2 edn. Springer-Verlag: Berlin, 1990, pp 7-10.
23. Sobin LH, Wittekind C. Stomach. In: Sobin LH, Wittekind C (eds). TNM Classification of Malignant Tumors. Union Internationale Contre le Cancer, 5 edn. Wiley-Liss: New York, 1997.
24. Wu Z, Irizarry RA, Gentleman R, et al. A model based background adjustment for oligonucleotide expression arrays. Johns Hopkins University, Department of Biostatistics Working Papers. 2004; Working Paper 1.
25. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Statist Soc Ser B 1995;57:289-300.
26. Bonferroni CE. Il calcolo delle assicurazioni su gruppi di teste. In: SO Carboni (ed). Studi in Onore del Professore Salvatore Ortu Carboni. Tipografia del Senato: Rome, 1935, pp 13-60.
27. Bluthgen N, Brand K, Cajavec B, et al. Biological profiling of gene groups utilizing Gene Ontology. Genome Inform 2005;16:106-115.
28. Rubie C, Kempf K, Hans J, et al. Housekeeping gene variability in normal and cancerous colorectal, pancreatic, esophageal, gastric and hepatic tissues. Mol Cell Probes 2005;19:101-109. (Pubitemid 40174728)
29. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-1108. (Pubitemid 351818697)
30. Juttner S, Wissmann C, Jons T, et al. Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma. J Clin Oncol 2006;24:228-240. (Pubitemid 46622052)
31. Yashiro M, Chung YS, Nishimura S, et al. Establishment of two new scirrhous gastric cancer cell lines: analysis of factors associated with disseminated metastasis. Br J Cancer 1995;72:1200-1210.
32. Takemura S, Yashiro M, Sunami T, et al. Novel models for human scirrhous gastric carcinoma in vivo. Cancer Sci 2004;95:893-900. (Pubitemid 40045524)
33. Yashiro M, Chung YS, Nishimura S, et al. Fibrosis in the peritoneum induced by scirrhous gastric cancer cells may act as 'soil' for peritoneal dissemination. Cancer 1996;77:1668-1675.
34. Motoyama T, Hojo H, Watanabe H. Comparison of seven cell lines derived from human gastric carcinomas. Acta Pathol Jpn 1986;36:65-83. (Pubitemid 16187837)
35. Gabbiani G, Ryan GB, Majne G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 1971;27:549-550.
36. Kim SY, Kim JH, Lee HS, et al. Meta-and gene set analysis of stomach cancer gene expression data. Mol Cells 2007;24:200-209.
37. Lawler J, McHenry K, Duquette M, et al. Characterization of human thrombospondin-4. J Biol Chem 1995;270:2809-2814.
38. Norsett KG, Laegreid A, Midelfart H, et al. Gene expression based classification of gastric carcinoma. Cancer Lett 2004;210:227-237. (Pubitemid 38748693)
39. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6:392-401.
40. Mahara K, Kato J, Terui T, et al. Transforming growth factor beta 1 secreted from scirrhous gastric cancer cells is associated with excess collagen deposition in the tissue. Br J Cancer 1994;69:777-783. (Pubitemid 24112705)
41. Arber S, Caroni P. Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth. J Cell Biol 1995;131:1083-1094.
42. Congote LF, Difalco MR, Gibbs BF. The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation. Biochem Biophys Res Commun 2004;324:673-678. (Pubitemid 39345569)
43. Sadvakassova G, Dobocan MC, Difalco MR, et al. Regulator of differentiation 1 (ROD1) binds to the amphipathic C-terminal peptide of thrombospondin-4 and is involved in its mitogenic activity. J Cell Physiol 2009;220:672-679.
44. Adams JC, Lawler J. Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1. Mol Biol Cell 1994;5:423-437. (Pubitemid 24178321)
45. Narouz-Ott L, Maurer P, Nitsche DP, et al. Thrombospondin-binds specifically to both collagenous and non-collagenous extracellular matrix proteins via its Cterminal domains. J Biol Chem 2000;275:37110-37117. (Pubitemid 32002129)
46. Korkola JE, DeVries S, Fridlyand J, et al. Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis. Cancer Res 2003;63: 7167-7175. (Pubitemid 37413454)
47. Rorive S, Maris C, Debeir O, et al. Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. J Neuropathol Exp Neurol 2006;65:794-807. (Pubitemid 44200320)
48. Sugimura J, Yang XJ, Tretiakova MS, et al. Gene expression profiling of mesoblastic nephroma and Wilms tumors-comparison and clinical implications. Urology 2004;64:362-368. (Pubitemid 39092472)
49. Turashvili G, Bouchal J, Burkadze G, et al. Differentiation of tumours of ductal and lobular origin: II. Genomics of invasive ductal and lobular breast carcinomas. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005;149:63-68.
50. Goodison S, Urquidi V, Tarin D. CD44 cell adhesion molecules. Mol Pathol 1999;52:189-196. (Pubitemid 29369203)
51. Naor D, Sionov RV, Ish-Shalom D. CD44: structure, function, and association with the malignant process. Adv Cancer Res 1997;71:241-319. (Pubitemid 27197761)
52. Sadvakassova G, Dobocan MC, Congote LF. Osteopontin and the C-terminal peptide of thrombospondin-4 compete for CD44 binding and have opposite effects on CD133+ cell colony formation. BMC Res Notes 2009;2:215.
53. Chen X, Leung SY, Yuen ST, et al. Variation in gene expression patterns in human gastric cancers. Mol Biol Cell 2003;14:3208-3215. (Pubitemid 37013121)
54. Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003;100:9440-9445. (Pubitemid 37033947)
55. Storey JD. A direct approach to false discovery rates. Journal of the Royal Statistical Society Series B 2002;64:479-498.