Treatment guided by rapid diagnostic tests for malaria in Tanzanian children: Safety and alternative bacterial diagnoses

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Mtove, George ^a   Hendriksen, Ilse C E ^b   Amos, Ben ^c   Mrema, Hedwiga ^c   Mandia, Victor ^c   Manjurano, Alphaxard ^d   Muro, Florida ^d   Sykes, Alma ^c   Hildenwall, Helena ^e   Whitty, Christopher J M ^f   Reyburn, Hugh ^d,f  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (Tanzania)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Teule Hospital   (Tanzania)

^d KILIMANJARO CHRISTIAN MEDICAL CENTRE   (Tanzania)

^e KAROLINSKA INSTITUTE   (Sweden)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; LACTIC ACID; ANTIMALARIAL AGENT; LACTIC ACID DERIVATIVE;

ARTICLE; AXILLA TEMPERATURE; BACTEREMIA; BLOOD CULTURE; BREATHING RATE; CHILD; COMPARATIVE STUDY; COUGHING; DIAGNOSTIC TEST; DIAGNOSTIC TEST ACCURACY STUDY; DIARRHEA; DYSPNEA; FEVER; FOLLOW UP; GROUPS BY AGE; HOSPITAL ADMISSION; HUMAN; INFANT; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALARIA; MEDICAL HISTORY; OUTCOME ASSESSMENT; PATIENT CARE PLANNING; PLASMODIUM FALCIPARUM; PREDICTIVE VALUE; PRESCHOOL CHILD; RAPID DIAGNOSTIC TEST; SAFETY; SENSITIVITY AND SPECIFICITY; TANZANIA; VOMITING; BLOOD; DRUG MONITORING; EVALUATION; FEMALE; MALARIA FALCIPARUM; MALE; METHODOLOGY; MICROBIOLOGY; PARASITOLOGY;

ANTIMALARIALS; BACTEREMIA; BLOOD; CHILD, PRESCHOOL; DIAGNOSTIC TESTS, ROUTINE; DRUG MONITORING; FEMALE; HUMANS; INFANT; LACTATES; MALARIA, FALCIPARUM; MALE; SENSITIVITY AND SPECIFICITY; TANZANIA;

EID: 80053536102     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-290     Document Type: Article

References (29)

1. Use of clinical algorithms for diagnosing malaria. Chandramohan D, Jaffar S, Greenwood B, Trop Med Int Health 2002 7 45 52 10.1046/j.1365-3156.2002. 00827.x 11851954 (Pubitemid 34131810)
2. Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever. D'Acremont V, Lengeler C, Mshinda H, Mtasiwa D, Tanner M, Genton B, PLoS Med 2009 6 252 10.1371/journal.pmed.0050252 19127974
3. Linking malaria rapid diagnostic test (RDT) and new drug combinations. Wongsrichanalai C, Baird K, BMJ 2004 bmj.com July 23.
4. Cost of increasing access to artemisinin combination therapy: the Cambodian experience. Yeung S, Van Damme W, Socheat D, White NJ, Mills A, Malar J 2008 7 84 10.1186/1475-2875-7-84 18492245 (Pubitemid 351945028)
5. Paediatric malaria case-management with artemether-lumefantrine in Zambia: a repeat cross-sectional study. Zurovac D, Ndhlovu M, Sipilanyambe N, Chanda P, Hamer DH, Simon JL, Snow RW, Malar J 2007 6 31 10.1186/1475-2875-6-31 17367518 (Pubitemid 46482315)
6. The cost-effectiveness of parasitologic diagnosis for malaria-suspected patients in an era of combination therapy. Lubell Y, Reyburn H, Mbakilwa H, Mwangi R, Chonya K, Whitty CJ, Mills A, Am J Trop Med Hyg 2007 77 128 132 18165484
7. Access to artemisinin combination therapy for malaria in remote areas of Cambodia. Yeung S, Van Damme W, Socheat D, White NJ, Mills A, Malar J 2008 7 96 10.1186/1475-2875-7-96 18510724 (Pubitemid 351990315)
8. Update on rapid diagnostic testing for malaria. Murray CK, Gasser RA, Magill AJ, Miller RS, Clin Microbiol Rev 2008 21 97 110 10.1128/CMR.00035-07 18202438 (Pubitemid 351160011)
9. Guidelines for malaria diagnosis and treatment. WHO, WHO-Roll Back Malaria WHO-Geneva 2010 vol. ISBN: 9789241547925
10. Guidelines and mindlines: why do clinical staff over-diagnose malaria in Tanzania? A qualitative study. Chandler CI, Jones C, Boniface G, Juma K, Reyburn H, Whitty CJ, Malar J 2008 7 53 10.1186/1475-2875-7-53 18384669 (Pubitemid 351551369)
11. Equity and coverage of insecticide-treated bed nets in an area of intense transmission of Plasmodium falciparum in Tanzania. Bernard J, Mtove G, Mandike R, Mtei F, Maxwell C, Reyburn H, Malar J 2009 8 65 10.1186/1475-2875-8-65 19371415
12. Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets. Maxwell CA, Chambo W, Mwaimu M, Magogo F, Carneiro IA, Curtis CF, Malar J 2003 2 28 10.1186/1475-2875-2-28 14585106
13. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Snounou G, Viriyakosol S, Zhu XP, Jarra W, Pinheiro L, do Rosario VE, Thaithong S, Brown KN, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
14. WHO guidelines for antimicrobial treatment in children admitted to hospital in an area of intense Plasmodium falciparum transmission: prospective study. Nadjm B, Amos B, Mtove G, Ostermann J, Chonya S, Wangai H, Kimera J, Msuya W, Mtei F, Dekker D, Malahiyo R, Olomi R, Crump JA, Whitty CJ, Reyburn H, BMJ 2010 340 1350 10.1136/bmj.c1350 20354024
15. Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children. Njama-Meya D, Clark TD, Nzarubara B, Staedke S, Kamya MR, Dorsey G, Malar J 2007 6 7 10.1186/1475-2875-6-7 17239256 (Pubitemid 46352350)
16. Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test. d'Acremont V, Malila A, Swai N, Tillya R, Kahama-Maro J, Lengeler C, Genton B, Clin Infect Dis 2010 51 506 511 10.1086/655688 20642354
17. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O, Saganda K, Shao J, Kitua A, Olomi R, Greenwood BM, Whitty CJ, Bmj 2004 329 1212 10.1136/bmj.38251.658229.55 15542534 (Pubitemid 39551443)
18. Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial. Konate AT, Yaro JB, Ouedraogo AZ, Diarra A, Gansane A, Soulama I, Kangoye DT, Kabore Y, Ouedraogo E, Ouedraogo A, Tiono AB, Ouedraogo IN, Chandramohan D, Cousens S, Milligan PJ, Sirima SB, Greenwood B, Diallo DA, PLoS Med 2011 8 1000408 10.1371/journal.pmed.1000408 21304925
19. Symptom overlap for malaria and pneumonia - policy implications for home management strategies. Kallander K, Nsungwa-Sabiiti J, Peterson S, Acta Trop 2004 90 211 214 10.1016/j.actatropica.2003.11.013 15177148 (Pubitemid 38283771)
20. Overlap in the clinical features of pneumonia and malaria in African children. O'Dempsey TJ, McArdle TF, Laurence BE, Lamont AC, Todd JE, Greenwood BM, Trans R Soc Trop Med Hyg 1993 87 662 665 10.1016/0035-9203(93)90279-Y 8296367
21. Clinical overlap between malaria and severe pneumonia in Africa children in hospital. English M, Punt J, Mwangi I, McHugh K, Marsh K, Trans R Soc Trop Med Hyg 1996 90 658 662 10.1016/S0035-9203(96)90423-X 9015508 (Pubitemid 27011161)
22. Local illness concepts - implications for management of childhood pneumonia in eastern Uganda. Hildenwall H, Rutebemberwa E, Nsabagasani X, Pariyo G, Tomson G, Peterson S, Acta Trop 2007 101 217 224 10.1016/j.actatropica.2007. 02.003 17374351 (Pubitemid 46517476)
23. The clinical spectrum of respiratory syncytial virus disease in The Gambia. Weber MW, Dackour R, Usen S, Schneider G, Adegbola RA, Cane P, Jaffar S, Milligan P, Greenwood BM, Whittle H, Mulholland EK, Pediatr Infect Dis J 1998 17 224 230 10.1097/00006454-199803000-00010 9535250 (Pubitemid 28146064)
24. Respiratory syncytial virus infection in tropical and developing countries. Weber MW, Mulholland EK, Greenwood BM, Trop Med Int Health 1998 3 268 280 10.1046/j.1365-3156.1998.00213.x 9623927 (Pubitemid 28232663)
25. Delivery of paediatric care at the first-referral level in Kenya. English M, Esamai F, Wasunna A, Were F, Ogutu B, Wamae A, Snow RW, Peshu N, Lancet 2004 364 1622 1629 10.1016/S0140-6736(04)17318-2 15519635 (Pubitemid 39446389)
26. Clinical assessment and treatment in paediatric wards in the north-east of the United Republic of Tanzania. Reyburn H, Mwakasungula E, Chonya S, Mtei F, Bygbjerg I, Poulsen A, Olomi R, Bull World Health Organ 2008 86 132 139 18297168 (Pubitemid 351213716)
27. Incidence of clinically significant bacteraemia in children who present to hospital in Kenya: community-based observational study. Brent AJ, Ahmed I, Ndiritu M, Lewa P, Ngetsa C, Lowe B, Bauni E, English M, Berkley JA, Scott JA, Lancet 2006 367 482 488 10.1016/S0140-6736(06)68180-4 16473125 (Pubitemid 43208904)
28. Bacteremia among children admitted to a rural hospital in Kenya. Berkley JA, Lowe BS, Mwangi I, Williams T, Bauni E, Mwarumba S, Ngetsa C, Slack MP, Njenga S, Hart CA, Maitland K, English M, Marsh K, Scott JA, N Engl J Med 2005 352 39 47 10.1056/NEJMoa040275 15635111 (Pubitemid 40075679)
29. Procalcitonin and C-reactive protein for invasive bacterial pneumonia diagnosis among children in Mozambique, a malaria-endemic area. Diez-Padrisa N, Bassat Q, Machevo S, Quinto L, Morais L, Nhampossa T, O'Callaghan-Gordo C, Torres A, Alonso PL, Roca A, PLoS One 2010 5 13226 10.1371/journal.pone.0013226 20976241