Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: A randomised, double-blind, placebo-controlled trial

PLoS Medicine

Volumn 8, Issue 2, 2011, Pages

  Konaté, Amadou T ^a   Yaro, Jean Baptiste ^a   Ouédraogo, Amidou Z ^a   Diarra, Amidou ^a   Gansané, Adama ^a   Soulama, Issiaka ^a   Kangoyé, David T ^a   Kaboré, Youssouf ^a   Ouédraogo, Espérance ^a   Ouédraogo, Alphonse ^a   Tiono, Alfred B ^a   Ouédraogo, Issa N ^a   Chandramohan, Daniel ^b   Cousens, Simon ^b   Milligan, Paul J ^b   Sirima, Sodiomon B ^a   Greenwood, Brian ^b   Diallo, Diadier A ^b  

^a Burkina Faso   (Burkina Faso)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMODIAQUINE; INSECTICIDE; PLACEBO; PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ANEMIA; ANOREXIA; ANTHROPOMETRY; ARTICLE; BED NET; BURKINA FASO; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSS-SECTIONAL STUDY; DIARRHEA; DISEASE SEVERITY; DISEASE SURVEILLANCE; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; DRUG ERUPTION; DRUG FEVER; DRUG INTERMITTENT THERAPY; FEMALE; FEVER; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; INCIDENCE; INFANT; INFECTION RISK; MAJOR CLINICAL STUDY; MALARIA; MALARIA CONTROL; MALE; PARASITE TRANSMISSION; PARASITEMIA; PREVALENCE; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; RISK REDUCTION; UNDERWEIGHT; VOMITING; DRUG COMBINATION; PRESCHOOL CHILD;

AMODIAQUINE; ANTIMALARIALS; BURKINA FASO; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; HUMANS; INFANT; INSECTICIDE-TREATED BEDNETS; MALARIA; PYRIMETHAMINE; SULFADOXINE;

EID: 79952275151     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1000408     Document Type: Article

References (32)

1. WHO (2008) World Malaria report 2008. WHO/HTM/GMP/2008.1. Geneva WHO.
2. Greenwood B, (2006) Intermittent preventive treatment-a new approach to the prevention of malaria in children in areas with seasonal malaria transmission. Trop Med Int Health 11: 983-991.
3. Schellenberg D, Menendez C, Kahigwa E, Aponte J, Vidal J, et al. (2001) Intermittent treatment for malaria and anaemia control at time of routine vaccination in Tanzanian infants; a randomised, placebo-controlled trial. Lancet 357: 1471-1477.
4. Institute of Medicine (2008) Available: http://www.iom.edu/Reports/2008/Assessment-of-the-Role-of-Intermittent-Preventive-Treatment-for-Malaria-in-Infants-Letter-Report.aspx. Accessed 10 July 2008.
5. Taylor T, Olola C, Valim C, Agbenyega T, Kremsner P, et al. (2006) Standardized data collection for multi-centre clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg 100: 615-622.
6. Cissé B, Sokhna C, Boulanger D, Milet J, Bâel H, et al. (2006) Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial. Lancet 367: 6596-67.
7. Dicko A, Sagara I, Sissoko MS, Guindo O, Diallo AI, et al. (2008) Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali. Malar J 7: 123.
8. Kweku M, Liu D, Adjuik M, Binka F, Seidu M, et al. (2008) Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial. PLoS One 3: e4000 doi:10.1371/journal.pone.0004000.
9. Lengeler C, (2004) Insecticide-treated bednets and curtains for preventing malaria. Cochrane Database Syst Rev pp. Cd000363.
10. Dicko A, Diallo AI, Tembine I, Dicko Y, Dara N, et al. (2011) A randomised, placebo-controlled trial of intermittent preventive treatment of malaria with sulphadoxine-pyrimethamine plus amodiaquine in children protected by long lasting insecticide treated nets in Mali. PLoS Med 8: e1000407 doi:10.1371/journal.pmed.1000407.
11. Zongo I, Dorsey G, Rouamba N, Dokomajilar C, Lankoande M, et al. (2005) Amodiaquine, sulfadoxine-pyrimethamine, combination therapy for the uncomplicated falciparum malaria: randomised controlled trial from Burkina Faso. Am. J Trop Med Hyg 73: 826-832.
12. Zongo I, Dorsey G, Rouamba N, Tinto H, Dokomajilar C, et al. (2007) Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet 369: 491-498.
13. Sokhna C, Cissé B, Bâel H, Milligan P, Hallett R, et al. (2008) A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children. PLoS One 3: e1471 doi:10.1371/journal.pone.0001471.
14. Ilboudo Sanogo E, (2001) Influence des rideaux imprégnés d'insecticide sur les paramètres entomologiques de la transmission du paludisme en zone rurale au Burkina Faso [PhD dissertation]. Ouagadougou, Burkina Faso Université de Ouagadougou, UFR Science de la Vie et de la Terre.
15. Abduallah S, Adazu K, Masanja H, Diallo DA, Hodgson A, et al. (2007) Patterns of age-specific malaria mortality in children in endemic areas of sub-Saharan Africa. Am J Trop Med and Hyg 77: 99-105.
16. Chandramohan D, Owusu-Agyei S, Carneiro I, Awine T, Amponsa-Achiano K, et al. (2005) Cluster randomised trial of intermittent preventive treatment of malaria in infants in area of high, seasonal malaria transmission in Ghana. BMJ 331: 727-33.
17. WHO (2000) Severe falciparum malaria. Trans R Soc Trop Med Hyg 94: S1-S10.
18. WHO (2009) Software for assessing growth and development of the world's children. Available: http://www.who.int/childgrowth/software/en/.
19. Smith PG, Morrow R, (1996) Field trials of health interventions in developing countries: a toolbox. London Macmillan.
20. Taylor WR, Terlouw DJ, Ollario PL, White NJ, Brasseur P, et al. (2006) Use of weight-for-age-data to optimize tablet strength and dosing regimens for a new fixed-dose artesunate-amodiaquine combination for treating falciparum malaria. Bull World Health Organ 84: 956-964.
21. Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE, (1995) Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52: 565-568.
22. Djimdé A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, et al. (2001) A molecular arker for chloroquine-resistant falciparum malaria. N Engl J Med 344: 257-263.
23. Marbiah NT, Petersen E, David K, Magbity E, Lines J, et al. (1998) A controlled trial of lambda-cyhalothrin-impregnated bed nets and/or dapsone/pyrimethamine for malaria control in Sierra Leone. Am J Trop Med Hyg 58: 1-6.
24. Alonso PL, Lindsay SW, Armstrong Schellenberg JR, Gomez P, Hill AG, et al. (1993) A malaria control trial using insecticide-treated bed nets and targeted chemoprophylaxis in a rural area of The Gambia, West Africa. 2. Mortality and morbidity from malaria in the study area. Trans R Soc Trop Med Hyg 87: 13-17.
25. Danquah I, Dietz E, Zanger P, Reither K, Ziniel P, et al. (2009) Reduced efficacy of intermittent preventive treatment of malaria in malnourished children. Antimicrob Agents Chemother 53: 1753-1759.
26. Ntab B, Cissé B, Boulanger D, Sokhna C, Targett G, et al. (2007) Impact of intermittent preventive anti-malarial treatment on the growth and nutritional status of preschool children in rural Senegal (west Africa). Am J Trop Med Hyg 77: 411-417.
27. Greenwood BM, Greenwood AM, Bradley AK, Snow RW, Byass P, et al. (1988) Comparison of two strategies for control of malaria within a primary health care programme in the Gambia. Lancet 1: 1121-1127.
28. Cisse B, Cairns M, Faye E, NDiaye O, Faye B, et al. (2009) Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children. PLoS One 4: e7164 doi:10.1371/journal.pone.0007164.
29. Cairns M, Cisse B, Sokhna C, Cames C, Simondon K, et al. (2010) Amodiaquine dosage and tolerability for intermittent preventive treatment to prevent malaria in children. Antimicrob Agents Chemother 54: 1265-1274.
30. Ord R, Alexander N, Dunyo S, Hallett R, Jawara M, et al. (2007) Seasonal carriage of pfcrt and pfmdr1 alleles in Gambian Plasmodium falciparum imply reduced fitness of chloroquine-resistant parasites. J Infect Dis 196: 1613-1619.
31. Kweku M, Webster J, Adjuik M, Abudey S, Greenwood B, et al. (2009) Options for the delivery of intermittent preventive treatment for malaria to children: a community randomised trial. PLoS One 4: e7256.
32. Bojang KA, Akor F, Conteh L, Webb EL, Bittaye O, et al. (2011) Two strategies for the delivery of IPTc in an area of seasonal malaria transmission: a randomized controlled trial. PLoS Med 8: e1000409 doi:10.1371/journal.pmed.1000409.