Genetics of common polygenic ischaemic stroke: Current understanding and future challenges

Stroke Research and Treatment

Volumn , Issue , 2011, Pages

  Bevan, Steve ^a   Markus, Hugh S ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC VARIABILITY; GENOMICS; HUMAN; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

EID: 80053534400     PISSN: None     EISSN: 20420056     Source Type: Journal    
DOI: 10.4061/2011/179061     Document Type: Review

References (37)

1. Flomann E., Schulz U. G. R., Rothwell P. M., Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke Stroke 2004 35 1 212 227 (Pubitemid 38057622)
2. Jerrard-Dunne P., Cloud G., Hassan A., Markus H. S., Evaluating the genetic component of ischemic stroke subtypes: a family history study Stroke 2003 34 6 1364 1369 (Pubitemid 36693499)
3. Polychronopoulos P., Gioldasis G., Ellul J., Metallinos I. C., Lekka N. P., Paschalis C., Papapetropoulos T., Family history of stroke in stroke types and subtypes Journal of the Neurological Sciences 2002 195 2 117 122 (Pubitemid 34202288)
4. Rubattu S., Volpe M., Kreutz R., Ganten U., Ganten D., Lindpaintner K., Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease Nature Genetics 1996 13 4 429 434 (Pubitemid 26256616)
5. Duggirala R., Villalpando C. G., O'Leary D. H., Stern M. P., Blangero J., Genetic basis of variation in carotid artery wall thickness Stroke 1996 27 5 833 837 (Pubitemid 26142511)
6. Jartti L., Ronnemaa T., Kaprio J., Population-based twin study of the effects of migration from Finland to Sweeden on endothelial function and intima-media thickness Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 832 837 (Pubitemid 34517797)
7. Moskau S., Golla A., Grothe C., Boes M., Pohl C., Klockgether T., Heritability of carotid artery atherosclerotic lesions: an ultrasound study in 154 families Stroke 2005 36 1 5 8 (Pubitemid 40054167)
8. Carmelli D., DeCarli C., Swan G. E., Jack L. M., Reed T., Wolf P. A., Miller B. L., Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins Stroke 1998 29 6 1177 1181 (Pubitemid 28265474)
9. Atwood L. D., Wolf P. A., Heard-Costa N. L., Massaro J. M., Beiser A., D'Agostino R. B., DeCarli C., Genetic variation in white matter hyperintensity volume in the Framingham study Stroke 2004 35 7 1609 1613 (Pubitemid 38823634)
10. Turner S. T., Fornage M., Jack C. R. Jr., Mosley T. H., Knopman D. S., Kardia S. L. R., Boerwinkle E., de Andrade M., Genomic susceptibility loci for brain atrophy, ventricular volume, and leukoaraiosis in hypertensive sibships Archives of Neurology 2009 66 7 847 857
11. Sinner M. F., Ellinor P. T., Meitinger T., Benjamin E. J., Kb S., Genome-wide association studies of atrial fibrillation: past, present, and future Cardiovascular Research 2011 89 4 701 709
12. Helgadottir A., Thorleifsson G., Magnusson K. P., The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm Nature Genetics 2008 40 2 217 224 (Pubitemid 351171400)
13. Hassan A., Markus H. S., Genetics and ischaemic stroke Brain 2000 123 9 1784 1812 (Pubitemid 30664283)
14. Tonk M., Haan J., A review of genetic causes of ischemic and hemorrhagic stroke Journal of the Neurological Sciences 2007 257 1-2 273 279 (Pubitemid 46856511)
15. Dichgans M., Markus H. S., Genetic association studies in stroke: methodological issues and proposed standard criteria Stroke 2005 36 9 2027 2031 (Pubitemid 41266548)
16. Casas J. P., Hingorani A. D., Bautista L. S., Sharma P., Meta-analysis of genetic studies in ischaemic stroke: thirty two genes involving approximately 18000 cases and 58000 controls Archives of Neurology 2004 61 1652 1661 (Pubitemid 39463422)
17. Meschia J. F., Brown R. D., Brott T. G., Hardy J., Atkinson E. J., O'Brien P. C., Feasibility of an affected sibling pair study in ischemic stroke: results of a 2-center family history registry Stroke 2001 32 12 2939 2941 (Pubitemid 33134493)
18. Worrall B. B., Chen D. T., Brown R. D., Brott T. G., Meschia J. F., A survey of the SWISS researchers on the impact of sibling privacy protections on pedigree recruitment Neuroepidemiology 2005 25 1 32 41 (Pubitemid 40864212)
19. Gretarsdottir S., Thorleifsson G., Reynisdottir S. T., The gene encoding phosphodiesterase 4D confers risk of ischemic stroke Nature Genetics 2003 35 2 131 138 (Pubitemid 37187631)
20. Bevan S., Dichgans M., Gschwendtner A., Kuhlenbumer G., Ringelstein E. B., Markus H. S., Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls Stroke 2008 39 7 1966 1971
21. Hardy J., Singleton A., Genomewide association studies and human disease The New England Journal of Medicine 2009 360 17 1759 1768
22. Edwards A. O., Ritter R., Abel K. J., Manning A., Panhuysen C., Farrer L. A., Complement factor H polymorphism and age-related macular degeneration Science 2005 308 5720 421 424 (Pubitemid 40530082)
23. The Wellcome Trust Case Control Consortium, Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 2007 447 7145 661 678
24. Matarn M., Brown W. M., Scholz S., A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release The Lancet Neurology 2007 6 5 414 420 (Pubitemid 46551853)
25. Ikram M. A., Seshadri S., Bis J. C., Genomewide association studies of stroke The New England Journal of Medicine 2009 360 17 1718 1728
26. International Stroke Genetic Consortium, Wellcome Trust Case Control Consortium 2, Failure to validate association between 12p13 variants and ischaemic stroke The New England Journal of Medicine 2010 362 16 1547 1550
27. Schunkert H., Gtz A., Braund P., Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease Circulation 2008 117 13 1675 1684 (Pubitemid 351482592)
28. Gschwendtner A., Bevan S., Cole J. W., Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke Annals of Neurology 2009 65 5 531 539
29. Gudbjartsson D. F., Arnar D. O., Helgadottir A., Variants conferring risk of atrial fibrillation on chromosome 4q25 Nature 2007 448 7151 353 357 (Pubitemid 47080348)
30. Gretarsdottir S., Thorleifsson G., Manolescu A., Risak variants for atrial fibrillation on chromosome 4q25 associate with ischaemic stroke Annals of Neurology 2008 64 4 402 409
31. Manolio T. A., Collins F. S., Cox N. J., Finding the missing heritability of complex diseases Nature 2009 461 7265 747 753
32. Metzker M. L., Sequencing technologiesthe next generation Nature Reviews Genetics 2010 11 1 31 46
33. Talmud P. J., Humphries S. E., Gene: environment interactions and coronary heart disease risk World Review of Nutrition and Dietetics 2004 93 29 40
34. Markus H. S., Labrum R., Bevan S., Reindl M., Egger G., Wiedermann C. J., Xu Q., Kiechl S., Willeit J., Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis Stroke 2006 37 9 2253 2259 (Pubitemid 44337165)
35. Stamova B., Xu H., Jickling G., Gene expression profiling of blood for the prediction of ischemic stroke Stroke 2010 41 10 2171 2177
36. Xu H., Tang Y., Liu D. Z., Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke Journal of Cerebral Blood Flow and Metabolism 2008 28 7 1320 1328 (Pubitemid 351896646)
37. Xu H., Stamova B., Jickling G., Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain Stroke 2010 41 12 2744 2749