Hepatic galactose metabolism quantified in humans using 2- 18F-fluoro-2-deoxy-D-galactose PET/CT

Journal of Nuclear Medicine

Volumn 52, Issue 10, 2011, Pages 1566-1572

  Sørensen, Michael ^a   Mikkelsen, Kasper Sandager ^a   Frisch, Kim ^a   Bass, Ludvik ^b   Bibby, Bo Martin ^c   Keiding, Susanne ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Galactose metabolism; Hepatic metabolic function; Michaelis Menten kinetics; Molecular imaging; Nuclear hepatology

Indexed keywords

2 DEOXY 2 FLUOROGALACTOSE F 18; GALACTOKINASE; GALACTOSE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARBOHYDRATE METABOLISM; COMPUTER ASSISTED EMISSION TOMOGRAPHY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HEPATIC ARTERY; HUMAN; HUMAN EXPERIMENT; LIVER BLOOD FLOW; LIVER CLEARANCE; LIVER METABOLISM; LIVER VEIN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIOACTIVITY;

AGED; FEMALE; FLUORINE RADIOISOTOPES; FUCOSE; GALACTOSE; HUMANS; INFUSIONS, INTRAVENOUS; KINETICS; LIVER; LIVER CIRCULATION; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REFERENCE VALUES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 80053518186     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.092924     Document Type: Article

References (34)

1. De Graaf W, Van Lienden KP, Dinant S, et al. Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection. J Gastrointest Surg. 2010;14:369-378.
2. Miki K, Kubota K, Inoue Y, Vera DR, Makuuchi M. Receptor measurements via Tc-GSA kinetic modeling are proportional to functional hepatocellular mass. J Nucl Med. 2001;42:733-737. (Pubitemid 32453461)
3. 18F]fluoro-2- deoxy-galactose positron emission tomography. Am J Physiol Gastrointest Liver Physiol. 2008;295:G27-G36.
4. 18F]fluoro-2-deoxy-D-galactose PET/CT: reproducibility of the method and metabolic heterogeneity in a normal pig liver model. Scand J Gastroenterol. 2011;46:98-103.
5. Tygstrup N. Effect of sites of blood sampling in determination of the galactose elimination capacity. Scand J Clin Lab Invest. 1977;37:333-338. (Pubitemid 8387586)
6. Schmidt LE, Ott P, Tygstrup N. Galactose elimination capacity as a prognostic marker in patients with severe acetaminophen-induced hepatotoxicity: 10 years'experience. Clin Gastroenterol Hepatol. 2004;2:418-424. (Pubitemid 38561240)
7. Merkel C, Marchesini G, Fabbri A, et al. The course of galactose elimination capacity in patients with alcoholic cirrhosis: possible use as a surrogate marker for death. Hepatology. 1996;24:820-823. (Pubitemid 26334280)
8. Jepsen P, Vilstrup H, Ott P, Keiding S, Andersen PK, Tygstrup N. The galactose elimination capacity and mortality in 781 Danish patients with newly-diagnosed liver cirrhosis: a cohort study. BMC Gastroenterol. 2009;9:50.
9. Redaelli CA, Dufour JF, Wagner M, et al. Preoperative galactose elimination capacity predicts complications and survival after hepatic resection. Ann Surg. 2002;235:77-85. (Pubitemid 34062402)
10. Timson DJ, Reece RJ. Sugar recognition by human galactokinase. BMC Biochem. 2003;4:16.
11. Timson DJ, Reece RJ. Functional analysis of disease-causing mutations in human galactokinase. Eur J Biochem. 2003;270:1767-1774. (Pubitemid 36532535)
12. Skak C, Keiding S. Methodological problems in the use of indocyanine green to estimate hepatic blood flow and ICG clearance in man. Liver. 1987;7:155-162. (Pubitemid 17110976)
13. 18F]fluoro-2-deoxy-D-galactose from Talose triflate and biodistribution in a porcine model. Nucl Med Biol. 2011;38:477-483.
14. Kurz G, Wallenfels K. D-Galactose, UV-test mit Galactose-dehydrogenase. In: Bergmeyer HU, ed. Methoden der Enzymatischen Analyse. Weinheim, Germany: Verlag Chemie; 1970:1241-1244.
15. Gjedde A. Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination. Brain Res. 1982;257:237-274. (Pubitemid 12064128)
16. Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983;3:1-7. (Pubitemid 13129630)
17. Winkler K, Bass L, Keiding S, Tygstrup N. The physiological basis for clearance measurements in hepatology. Scand J Gastroenterol. 1979;14:439-448. (Pubitemid 9232237)
18. Crone C. The permeability of capillaries in various organs as determined by use of the "indicator diffusion" method. Acta Physiol Scand. 1963;58:292-305.
19. Winkler K, Bass L, Henriksen J, Larsen OA, Ring P, Tygstrup N. Heterogeneity of splanchnic vascular transit times in man. Clin Physiol. 1983;3:537-544. (Pubitemid 14213987)
20. Keiding S, Johansen S, Winkler K. Hepatic galactose elimination kinetics in the intact pig. Scand J Clin Lab Invest. 1982;42:253-259. (Pubitemid 12085124)
21. Bass L, Keiding S, Winkler K, Tygstrup N. Enzymatic elimination of substrates flowing through the intact liver. J Theor Biol. 1976;61:393-409.
22. Keiding S, Johansen S, Winkler K, Tønnesen K, Tygstrup N. Michaelis Menten kinetics of galactose elimination by the isolated perfused pig liver. Am J Physiol. 1976;230:1302-1313.
23. Seber GAF, Wild CJ. Non-Linear Regression. New York, NY: John Wiley & Sons; 1989.
24. Keiding S. Galactose clearance measurements and liver blood flow. Gastroenterology. 1988;94:477-481. (Pubitemid 18054788)
25. Doi R, Inoue K, Kogire M, et al. Simultaneous measurements of hepatic arterial and portal venous flows by transit time ultrasonic volume flowmetry. Surg Gynecol Obstet. 1988;167:65-69.
26. Henderson JM, Hanna SS. Effective liver blood flow: determination by galactose clearance. Can J Surg. 1983;26:129-132. (Pubitemid 13105068)
27. Diem K, Lentner C, eds. Documenta Geigy Scientific Tables. Switzerland: J.R. Geigy S.A; 1970.
28. Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. J Biol Chem. 2005;280: 9662-9670. (Pubitemid 40409664)
29. Dixon M, Webb EC. Enzymes. Suffolk, U.K.: Longman; 1979.
30. Iozzo P, Jarvisalo MJ, Kiss J, et al. Quantification of liver glucose metabolism by positron emission tomography: validation study in pigs. Gastroenterology. 2007; 132:531-542. (Pubitemid 46274671)
31. Maharaj B, Maharaj RJ, Leary WP, et al. Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet. 1986; 1:523-525. (Pubitemid 16138427)
32. Janiec DJ, Jacobson ER, Freeth A, Spaulding L, Blaszyk H. Histologic variation of grade and stage of non-alcoholic fatty liver disease in liver biopsies. Obes Surg. 2005;15:497-501. (Pubitemid 40605072)
33. Iozzo P, Bucci M, Roivainen A, et al. Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals. Gastroenterology. 2010;139:846-856.
34. 18F-FDG PET in pigs. J Nucl Med. 2011; 52:1119-1124.