Frequent loss of p19INK4D expression in hepatocellular carcinoma: Relationship to tumor differentiation and patient survival

Oncology Reports

Volumn 26, Issue 6, 2011, Pages 1363-1368

  Morishita, Asahiro ^a   Gong, Jian ^b   Deguchi, Akihiro ^b   Tani, Joji ^b   Miyoshi, Hisaaki ^b   Yoshida, Hirohito ^b   Himoto, Takashi ^b   Yoneyama, Hirohito ^b   Mori, Hirohito ^b   Kato, Kiyohito ^b   Kurokohchi, Kazutaka ^b   Deguchi, Kazushi ^b   Izuishi, Kunihiko ^b   Suzuki, Yasushi ^b   Kushida, Yoshio ^b   Haba, Reiji ^b   Iwama, Hisaaki ^b   Watanabe, Seishiro ^b   D'Armiento, Jeanine ^a   Masaki, Tsutomu ^b  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Cdk; Differentiation; Hepatocellular carcinoma; p19INK4D

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2D;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; OVERALL SURVIVAL; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RISK FACTOR; SEX RATIO; TUMOR DIFFERENTIATION; CANCER GRADING; CHRONIC HEPATITIS; GENE EXPRESSION; GENETICS; LIVER CIRRHOSIS; LIVER TUMOR; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P19; FEMALE; GENE EXPRESSION; HEPATITIS, CHRONIC; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM GRADING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS;

EID: 80053516909     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1452     Document Type: Article

References (36)

1. Kudo M: Radiofrequency ablation for hepatocellular carcinoma: updated review in 2010. Oncology 78 (Suppl 1): 113-124, 2010.
2. Zhou Y, Zhao Y, Li B, et al: Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma. BMC Gastroenterol 10: 78, 2010.
3. Gerdes B, Ramaswamy A, Ziegler A, et al: p16INK4a is a prognostic marker in resected ductal pancreatic cancer: an analysis of p16INK4a, p53, MDM2, an Rb. Ann Surg 235: 51-59, 2002. (Pubitemid 34062399)
4. Kudoh K, Ichikawa Y, Yoshida S, et al: Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer. Int J Cancer 99: 579-582, 2002. (Pubitemid 34461612)
5. Nakai S, Masaki T, Shiratori Y, et al: Expression of p57(KIP2) in hepatocellular carcinoma: relationship between tumor differentiation and patient survival. Int J Oncol 20: 769-775, 2002.
6. Ohgi T, Masaki T, Nakai S, et al: Expression of p33(ING1) in hepatocellular carcinoma: relationships to tumour differentiation and cyclin E kinase activity. Scand J Gastroenterol 37: 1440-1448, 2002. (Pubitemid 36051506)
7. Sandhu C and Slingerland J: Deregulation of the cell cycle in cancer. Cancer Detect Prev 24: 107-118, 2000. (Pubitemid 30427696)
8. Bloom J and Pagano M: Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol 13: 41-47, 2003. (Pubitemid 36269179)
9. Dobashi Y: Cell cycle regulation and its aberrations in human lung carcinoma. Pathol Int 55: 95-105, 2005.
10. Harper JW and Elledge SJ: Cdk inhibitors in development and cancer. Curr Opin Genet Dev 6: 56-64, 1996. (Pubitemid 26059052)
11. Sherr CJ and Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163, 1995.
12. Hui AM, Sakamoto M, Kanai Y, et al: Inactivation of p16INK4 in hepatocellular carcinoma. Hepatology 24: 575-579, 1996.
13. Sherr CJ: Cancer cell cycles. Science 274: 1672-1677, 1996.
14. Morishita A, Masaki T, Yoshiji H, et al: Reduced expression of cell cycle regulator p18(INK4C) in human hepatocellular carcinoma. Hepatology 40: 677-686, 2004. (Pubitemid 39265590)
15. Sherr CJ: G1 phase progression: cycling on cue. Cell 79: 551-555, 1994.
16. Xia W, Chen JS, Zhou X, et al: Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res 10: 3815-3824, 2004. (Pubitemid 38697617)
17. He S, Lu M, Xue W, et al: Phosphorylated p27(Kip1) on Thr157 is an important prognosis in human hepatocellular carcinoma in vivo and in vitro. Med Oncol 28: 94-104, 2011.
18. Duncan TJ, Al-Attar A, Rolland P, Harper S, Spendlove I and Durrant LG: Cytoplasmic p27 expression is an independent prognostic factor in ovarian cancer. Int J Gynecol Pathol 29: 8-18, 2010.
19. Seki R, Ohshima K, Fujisaki T, et al: Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma: effects of rituximab. Ann Oncol 21: 833-841, 2010.
20. Shen A, Wang Y, Zhao Y, Zou L, Sun L and Cheng C: Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis. Neurosurgery 65: 153-160, 2009.
21. Miyabe S, Okabe M, Nagatsuka H, et al: Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases. J Oral Maxillofac Surg 67: 1432-1441, 2009.
22. Fukai K, Yokosuka O, Imazeki F, et al: Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma. Liver Int 25: 1209-1216, 2005. (Pubitemid 41782567)
23. Desmet VJ, Gerber M, Hoofnagle JH, Manns M and Scheuer PJ: Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19: 1513-1520, 1994. (Pubitemid 24166476)
24. Terminology of nodular hepatocellular lesions. International Working Party. Hepatology 22: 983-993, 1995.
25. Yamagata M, Masaki T, Okudaira T, et al: Small hyperechoic nodules in chronic liver diseases include hepatocellular carcinomas with low cyclin D1 and Ki-67 expression. Hepatology 29: 1722-1729, 1999. (Pubitemid 29247045)
26. Hunyady B, Krempels K, Harta G and Mezey E: Immunohistochemical signal amplification by catalyzed reporter deposition and its application in double immunostaining. J Histochem Cytochem 44: 1353-1362, 1996.
27. Matsuda Y and Ichida T: p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis. Med Mol Morphol 39: 169-175, 2006. (Pubitemid 46013053)
28. INK4D in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. Oncogene 19: 4146-4150, 2000.
29. Yang TL, Su YR, Huang CS, et al: High-resolution 19p13.2-13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity. Genes Chromosomes Cancer 41: 250-256, 2004.
30. Gunduz E, Gunduz M, Ouchida M, et al: Genetic and epigenetic alterations of BRG1 promote oral cancer development. Int J Oncol 26: 201-210, 2005.
31. INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1. Blood 111: 4081-4091, 2008.
32. Takenaka K, Kawahara N, Yamamoto K, et al: Results of 280 liver resections for hepatocellular carcinoma. Arch Surg 131: 71-76, 1996. (Pubitemid 26015411)
33. Niklinski J, Niklinska W, Laudanski J, Chyczewska E and Chyczewski L: Prognostic molecular markers in non-small cell lung cancer. Lung Cancer 34 (Suppl 2): S53-S58, 2001. (Pubitemid 33101846)
34. Tannapfel A, Grund D, Katalinic A, et al: Decreased expression of p27 protein is associated with advanced tumor stage in hepatocellular carcinoma. Int J Cancer 89: 350-355, 2000. (Pubitemid 30620288)
35. Tannapfel A, Wasner M, Krause K, et al: Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma. J Natl Cancer Inst 91: 1154-1158, 1999. (Pubitemid 29330554)
36. Qin LX and Tang ZY: The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol 8: 385-392, 2002.