Genetically modified lactococcus lactis for delivery of human interleukin-10 to dendritic cells

Gastroenterology Research and Practice

Volumn , Issue , 2012, Pages

  Braat, Henri ^b   Huibregtse, Inge L ^a   Zaat, Sebatian A ^a   Kapsenberg, Martien L ^a   Sartori Da Silva, Maria A ^b   Peppelenbosch, Maikel P ^b   Van Deventer, Sander J H ^c  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD83 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 10; PROBIOTIC AGENT; RECOMBINANT INTERLEUKIN 10;

ARTICLE; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; IN VITRO STUDY; LACTOCOCCUS LACTIS; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; SUPPRESSOR CELL;

EID: 80053498756     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2012/639291     Document Type: Article

References (26)

1. Coombes J. L., Powrie F., Dendritic cells in intestinal immune regulation Nature Reviews Immunology 2008 8 6 435 446 (Pubitemid 351733420)
2. van Montfrans C., Rodriguez Pena M. S., Pronk I., ten Kate F. J. W., te Velde A. A., van Deventer S. J. H., Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model Gastroenterology 2002 123 6 1865 1876 (Pubitemid 35408311)
3. Steidler L., Hans W., Schotte L., Neirynck S., Obermeier F., Falk W., Fiers W., Remaut E., Treatment of murine colitis by Lactococcus lactis secreting interleukin-10 Science 2000 289 5483 1352 1355 (Pubitemid 30656052)
4. Davidson N. J., Hudak S. A., Lesley R. E., Menon S., Leach M. W., Rennick D. M., IL-12, but not IFN-, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice Journal of Immunology 1998 161 6 3143 3149 (Pubitemid 28425743)
5. van Deventer S. J. H., Elson C. O., Fedorak R. N., Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn's disease Gastroenterology 1997 113 2 383 389 (Pubitemid 27351761)
6. Fedorak R. N., Gangl A., Elson C. O., Safety, tolerance and efficacy of multiple doses of subcutaneous interleukin-10 in mild to moderate active Crohn's disease (STAMM-CD) Gastroenterology 1998 114 4 G3993
7. Tilg H., Kaser A., Propst A., Recombinant human interleukin-10 (rHuIL-10) therapy steroid-refractory chronic active Crohn's disease (CACD): induction of neopterin, a degradation product of the pteridine pathway regulated by interferon-gamma Gastroenterology 1998 114 4 G4500
8. Colombel J., Rutgeerts P., Malchow H., Safety and tolerance of subcutaneous recombinant human interleukin-10 (IL-10) in subjects with Crohn's disease after first ileal or ileocolonic resection Gastroenterology 1999 116 4 G3000
9. Braat H., Rottiers P., Hommes D. W., Huyghebaert N., Remaut E., Remon J. P., van Deventer S. J. H., Neirynck S., Peppelenbosch M. P., Steidler L., A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease Clinical Gastroenterology and Hepatology 2006 4 6 754 759 (Pubitemid 43841860)
10. Kapsenberg M. L., Dendritic-cell control of pathogen-driven T-cell polarization Nature Reviews Immunology 2003 3 12 984 993 (Pubitemid 37521540)
11. Monteleone I., Platt A. M., Jaensson E., Agace W. W., Mowat A. M., IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function European Journal of Immunology 2008 38 6 1533 1547
12. Steinbrink K., Graulich E., Kubsch S., Knop J., Enk A. H., CD4 + and CD8 + anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity Blood 2002 99 7 2468 2476 (Pubitemid 34525434)
13. Foligne B., Dessein R., Marceau M., Poiret S., Chamaillard M., Pot B., Simonet M., Daniel C., Prevention and Treatment of Colitis With Lactococcus lactis Secreting the Immunomodulatory Yersinia LcrV Protein Gastroenterology 2007 133 3 862 874 (Pubitemid 47374132)
14. Braat H., van den Brande J., van Tol E., Hommes D., Peppelenbosch M., van Deventer S., Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4 + T cells via modulation of dendritic cell function American Journal of Clinical Nutrition 2004 80 6 1618 1625 (Pubitemid 41103862)
15. Smits H. H., Engering A., van der Kleij D., De Jong E. C., Schipper K., van Capel T. M. M., Zaat B. A. J., Yazdanbakhsh M., Wierenga E. A., van Kooyk Y., Kapsenberg M. L., Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin Journal of Allergy and Clinical Immunology 2005 115 6 1260 1267 (Pubitemid 40824599)
16. Steinman R. M., Banchereau J., Taking dendritic cells into medicine Nature 2007 449 7161 419 426 (Pubitemid 47509552)
17. Di Giacinto C., Marinaro M., Sanchez M., Strober W., Boirivant M., Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF- -bearing regulatory cells Journal of Immunology 2005 174 6 3237 3246 (Pubitemid 40354026)
18. Niers L. E. M., Timmerman H. M., Rijkers G. T., van Bleek G. M., van Uden N. O. P., Knol E. F., Kapsenberg M. L., Kimpen J. L. L., Hoekstra M. O., Identification of strong interleukin-10 inducing lactic acid bacteria which down-regulate T helper type 2 cytokines Clinical and Experimental Allergy 2005 35 11 1481 1489
19. Steinbrink K., Wlfl M., Jonuleit H., Knop J., Enk A. H., Induction of tolerance by IL-10-treated dendritic cells Journal of Immunology 1997 159 10 4772 4780 (Pubitemid 127471012)
20. Steinbrink K., Jonuleit H., Mller G., Schuler G., Knop J., Enk A. H., Interleukin-10-treated human dendritic cells induce a melanoma-antigen- specific anergy in CD8 + T cells resulting in a failure to lyse tumor cells Blood 1999 93 5 1634 1642 (Pubitemid 29102491)
21. Waeytens A., Ferdinande L., Neirynck S., Rottiers P., De Vos M., Steidler L., Cuvelier C. A., Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice Inflammatory Bowel Diseases 2008 14 4 471 479 (Pubitemid 351571826)
22. Akbari O., DeKruyff R. H., Umetsu D. T., Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen Nature Immunology 2001 2 8 725 731 (Pubitemid 32747162)
23. Bianchini R., Bistoni O., Alunno A., CD4 + CD25low GITR + cells: a novel human CD4 + T cell population with regulatory activity. European Journal of Immunology. In press
24. Barnes M. J., Powrie F., Regulatory T cells reinforce intestinal homeostasis Immunity 2009 31 3 401 411
25. Xin K. Q., Hoshino Y., Toda Y., Igimi S., Kojima Y., Jounai N., Ohba K., Kushiro A., Kiwaki M., Hamajima K., Klinman D., Okuda K., Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env Blood 2003 102 1 223 228 (Pubitemid 36759658)
26. Pant N., Hultberg A., Zhao Y., Svensson L., Pan-Hammarstrm Q., Johansen K., Pouwels P. H., Ruggeri F. M., Hermans P., Frenken L., Borén T., Marcotte H., Hammarstrm L., Lactobacilli expressing variable domain of llama heavy-chain antibody fragments (lactobodies) confer protection against rotavirus-induced diarrhea Journal of Infectious Diseases 2006 194 11 1580 1588 (Pubitemid 44851901)