Stiff leg syndrome and myelitis with anti-amphiphysin antibodies: A common physiopathology?

European Neurology

Volumn 66, Issue 5, 2011, Pages 253-255

  Chamard, Ludivine ^a   Magnin, Eloi ^a   Berger, Eric ^a   Hagenkötter, Beate ^b   Rumbach, Lucien ^a   Bataillard, Marc ^b  

^a UNIVERSITY HOSPITAL OF BESANÇON   (France)

^b Hospital of Belfort Montbeliard   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIPHYSIN ANTIBODY; BACLOFEN; CORTICOSTEROID; DIAZEPAM; IMMUNOGLOBULIN G; PROTEIN ANTIBODY; TIZANIDINE; UNCLASSIFIED DRUG;

AGED; BREAST BIOPSY; BREAST CARCINOMA; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CORTICOSTEROID THERAPY; DYSTONIA; ECHOMAMMOGRAPHY; EXTENSOR HALLUCIS LONGUS MUSCLE; EXTENSOR MUSCLE; FEMALE; HUMAN; HUMAN TISSUE; LEG CRAMP; LEG DISEASE; LEG PAIN; LETTER; MULTIMODALITY CANCER THERAPY; MUSCLE HYPERTONIA; MUSCLE HYPERTROPHY; MUSCULOSKELETAL STIFFNESS; MYELITIS; PATHOPHYSIOLOGY; PLEOCYTOSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; STIFF LEG SYNDROME; TIBIALIS ANTERIOR MUSCLE;

AGED; ANTIBODIES, ANTI-IDIOTYPIC; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MYELITIS; NERVE TISSUE PROTEINS; SPINAL CORD; STIFF-PERSON SYNDROME;

EID: 80053483517     PISSN: 00143022     EISSN: 14219913     Source Type: Journal    
DOI: 10.1159/000331592     Document Type: Letter

References (24)

1. Moersch F, Woltman H: Progressive fluctuating muscular rigidity and spasm ('stiffman' syndrome): report a case and some observations in 13 other cases. Proc Staff Meet Mayo Clin 1956; 31: 421-427.
2. Brown P, Marsden CD: The stiff man syndrome and stiff man plus syndromes. J Neurol 1999; 246: 648-652. (Pubitemid 29417843)
3. Barker RA, Revesz T, Thom M, Marsden CD, Brown P: Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity. J Neurol Neurosurg Psychiatry 1998; 65: 633-640. (Pubitemid 28486637)
4. Gurol ME, Ertas M, Hanagasi HA, Gürsoy G, Emre M: Stiff leg syndrome: case report. Mov Disord 2001; 16: 1189-1193. (Pubitemid 36041243)
5. Hattan E, Angle MR, Chalk C: Unexpected benefit of propofol in stiff-person syndrome. Neurology 2008; 70: 1641-1642. (Pubitemid 351620322)
6. Saiz A, Graus F, Valldeoriola F, Valls-Solé J, Tolosa E: Stiff-leg syndrome: a focal form of stiff-man syndrome. Ann Neurol 1998; 43: 400-403. (Pubitemid 28113607)
7. Cantiniaux S, Azulay JP, Boucraut J, Poujet J, Attarian S: Stiff man syndrome: clinical forms, treatments and clinical course. Rev Neurol 2006; 162: 832-839. (Pubitemid 44359170)
8. Silverman IE: Paraneoplastic stiff limb syndrome. J Neurol Neurosurg Psychiatry 1999; 67: 126-127.
9. Bartsch T, Herzog J, Baron R, Deutschl G: The stiff limb syndrome - a new case and a literature review. J Neurol 2003; 250: 488-490. (Pubitemid 36459758)
10. Kocak E, Abdessalam S, Walker MJ, Nuovo GJ, Kissel JT: Stiff-person syndrome: a rare presentation for breast cancer. Breast J 2004; 10: 552-553. (Pubitemid 39524996)
11. Shiraishi H, Motomura M, Iwanaga H, Tsujino A, Nishiura Y, Shirabe S, Nakamura T, Yoshimura T: Successful treatment in a patient with a focal form of stiff-person syndrome using plasma exchange and intravenous immunoglobulin therapy (in Japanese). Rinsho Shinkeigaku 2002; 42: 766-770. (Pubitemid 36362458)
12. Weatherby SJ, Woolner P, Clarke CE: Pregnancy in stiff-limb syndrome. Mov Disord 2004; 19: 852-854. (Pubitemid 39139606)
13. Coles A, Barker R: A case of stiff limb syndrome responsive to plasma exchange. J Neurol Neurosurg Psychiatry 2001; 70: 407-408. (Pubitemid 32250907)
14. Souza-Lima CF, Ferraz HB, Braz CA, Araüjo AM, Manzano GM: Market improvement in a stiff-limb patient treated with intravenous immunoglobulin. Mov Disord 2000; 15: 358-359. (Pubitemid 30166755)
15. Hajjioui A, Benbouazza K, Faris Mel A, Missaoui A, Hassouni NH: Stiff limb syndrome: a case report. Cases J 2010; 3: 60.
16. Holmøy T, Horn MA, Vandvik B: A stifflegged man with a bizarre gait. Tidsskr Nor Laegeforen 2007; 127: 1529-1530.
17. Calvet D, Touzé E, Delegue P, Bertherat J, Zuber M: Syndrome des membres raides associé à une encéphalopathie d'Hashimoto: effet favorable des corticoïdes. Rev Neurol 2002; 158: 602-604. (Pubitemid 34534831)
18. Schiff D, Dalmau J, Myers DJ: Anti-GAD antibody positive stiff-limb syndrome in multiple myeloma. J Neurooncol 2003; 65: 173-175. (Pubitemid 37521317)
19. Holmøy T: Long-term effect of gabapentin in stiff limb syndrome: a case report. Eur Neurol 2007; 58: 251-252. (Pubitemid 350175896)
20. Virani S, Tan M, Abraham J: Transverse myelitis: amphiphysin autoimmunity paraneoplastic syndrome in a woman with breast cancer. Clin Adv Hematol Oncol 2009; 7: 180-182.
21. Holmøy T, Skorstad G, Roste LS, Scheie D, Alvik K: Stiff person syndrome associated with lower motor neuron disease and infiltration of cytotoxic T cells in the spinal cord. Clin Neurol Neurosurg 2009; 111: 708-712.
22. Pittock SJ, Lucchinetti CF, Parisi JE, Benarroch EE, Mokri B, Stephan CL, Kim KK, Kilimann MW, Lennon VA: Amphiphysine autoimmunity: paraneoplastic accompaniments. Ann Neurol 2005; 58: 96-107.
23. Pittock SJ, Lucchinetti CF: Inflammatory transverse myelitis: evolving concepts. Curr Opin Neurol 2006; 19: 362-368.
24. Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Üçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M, Sommer C: Stiff person syndrome-associated autoantibodies to amphiphysin mediated reduced GABAergic inhibition. Brain 2010; 133: 3166-3180.