Resistin is Associated with Breach of Tolerance and Anti-nuclear Antibodies in Patients with Hepatobiliary Inflammation

Scandinavian Journal of Immunology

Volumn 74, Issue 5, 2011, Pages 463-470

  Bostrom E A ^a   Ekstedt, M ^b   Kechagias, S ^b   Sjowall C ^b   Bokarewa, M I ^a   Almer, S ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; INTERLEUKIN 6; INTERLEUKIN 8; MITOCHONDRION ANTIBODY; RESISTIN; SMOOTH MUSCLE ANTIBODY;

ARTICLE; AUTOIMMUNE HEPATITIS; BLOOD ANALYSIS; CONTROLLED STUDY; CROHN DISEASE; DIGESTIVE SYSTEM INFLAMMATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL TRACT; HEPATOBILIARY INFLAMMATION; HUMAN; IMMUNOLOGICAL TOLERANCE; LIVER FUNCTION; MAJOR CLINICAL STUDY; NONALCOHOLIC FATTY LIVER; PHENOTYPE; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; REMISSION; ULCERATIVE COLITIS;

ADULT; AGED; ANTIBODIES, ANTINUCLEAR; BIOLOGICAL MARKERS; CHOLANGITIS, SCLEROSING; DISEASE PROGRESSION; FATTY LIVER; GENE EXPRESSION REGULATION; HEPATITIS; HUMANS; IMMUNE TOLERANCE; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; RESISTIN;

EID: 80053473262     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2011.02592.x     Document Type: Article

References (41)

1. Czaja AJ, Norman GL. Autoantibodies in the diagnosis and management of liver disease. J Clin Gastroenterol 2003;37:315-29.
2. Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 2005;435:590-7.
3. Longhi MS, Hussain MJ, Mitry RR et al. Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis. J Immunol 2006;176:4484-91.
4. Behr MA, Divangahi M, Lalande JD. What's in a name? The (mis)labelling of Crohn's as an autoimmune disease. Lancet 2010;376:202-3.
5. Steppan CM, Brown EJ, Wright CM et al. A family of tissue-specific resistin-like molecules. Proc Natl Acad Sci U S A 2001;98:502-6.
6. Holcomb IN, Kabakoff RC, Chan B et al. FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. EMBO J 2000;19:4046-55.
7. Artis D, Wang ML, Keilbaugh SA et al. RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc Natl Acad Sci U S A 2004;101:13596-600.
8. Nagaev I, Bokarewa M, Tarkowski A, Smith U. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes. PLoS ONE 2006;1:e31.
9. Steppan CM, Bailey ST, Bhat S et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-12.
10. Pang SS, Le YY. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol 2006;3:29-34.
11. Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol 2005;174:5789-95.
12. Johansson L, Linnér A, Sundén-Cullberg J et al. Neutrophil-derived hyperresistinemia in severe acute streptococcal infections. J Immunol 2009;183:4047-54.
13. Sundén-Cullberg J, Nyström T, Lee ML et al. Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock. Crit Care Med 2007;35:1536-42.
14. Baker R, Dauner JG, Rodriguez AC et al. Increased plasma levels of adipokines and inflammatory markers in older women with persistent HPV infection. Cytokine 2011;53:282-5.
15. Herbert DR, Yang JQ, Hogan SP et al. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med 2009;206:2947-57.
16. Almehed K, d'Elia HF, Bokarewa M, Carlsten H. Role of resistin as a marker of inflammation in systemic lupus erythematosus. Arthritis Research Ther 2008;10:R15.
17. Boström EA, d'Elia HF, Dahlgren U et al. Salivary resistin reflects local inflammation in Sjögren's syndrome. J Rheumatol 2008;35:2005-11.
18. Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA. Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. Inflamm Bowel Dis 2006;12:100-5.
19. Konrad A, Lehrke M, Schachinger V et al. Resistin is an inflammatory marker of inflammatory bowel disease in humans. Eur J Gastroenterol Hepatol 2007;19:1070-4.
20. Paul G, Schäffler A, Neumeier M et al. Profiling adipocytokine secretion from creeping fat in Crohn's disease. Inflamm Bowel Dis 2006;12:471-7.
21. Karmiris K, Koutroubakis IE. Resistin: another rising biomarker in inflammatory bowel disease? Eur J Gastroenterol Hepatol 2007;19:1035-7.
22. Durazzo M, Niro G, Premoli A et al. Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression? J Gastroenterol 2009;44:476-82.
23. Tiftikci A, Atug O, Yilmaz Y et al. Serum levels of adipokines in patients with chronic HCV infection: relationship with steatosis and fibrosis. Arch Med Res 2009;40:294-8.
24. Pagano C, Soardo G, Pilon C et al. Increased serum resistin in non-alcoholic fatty liver disease is related to liver disease severity and not to insulin resistance. J Clin Endocrinol Metab 2006;91:1081-6.
25. Ekstedt M, Franzen LE, Mathiesen UL et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865-73.
26. Evans JG, Acheson ED. An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area. Gut 1965;6:311-24.
27. Werner M, Prytz H, Ohlsson B et al. Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: a nationwide study. Scand J Gastroenterol 2008;43:1232-40.
28. Alvarez F, Berg PA, Bianchi FB et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol 1999;31:929-38.
29. Wiesner RH, LaRusso NF. Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology 1980;79:200-6.
30. Bogdanos DP, Invernizzi P, Mackay IR, Vergani D. Autoimmune liver serology: current diagnostic and clinical challenges. World J Gastroenterol 2008;14:3374-87.
31. Gonzalez-Gay MA, Garcia-Unzueta MT, Gonzalez-Juanatey C et al. Anti-TNF-alpha therapy modulates resistin in patients with rheumatoid arthritis. Clin Exp Rheumatol 2008;26:311-6.
32. LaRochelle J, Freiler J, Dice J, Hagan L. Plasma resistin levels in asthmatics as a marker of disease state. J Asthma 2007;44:509-13.
33. Walcher D, Hess K, Berger R et al. Resistin - a newly identified chemokine for human CD4-positive lymphocytes. Cardiovasc Res 2010;85:167-74.
34. Son YM, Ahn SM, Jang MS et al. Immunomodulatory effect of resistin in human dendritic cells stimulated with lipoteichoic acid from Staphylococcus aureus. Biochem Biophys Res Commun 2008;376:599-604.
35. Nair MG, Guild KJ, Du Y et al. Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation. J Immunol 2008;181:4709-15.
36. Patel L, Buckels AC, Kinghorn IJ et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun 2003;300:472-6.
37. Boström EA, Tarkowski A, Bokarewa M. Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli. Biochim Biophys Acta 2009;1793:1894-900.
38. Bertolani C, Sancho-Bru P, Failli P et al. Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells. Am J Pathol 2006;169:2042-53.
39. Sheng CH, Di J, Jin Y et al. Resistin is expressed in human hepatocytes and induces insulin resistance. Endocrine 2008;33:135-43.
40. Yagmur E, Trautwein C, Gressner AM, Tacke F. Resistin serum levels are associated with insulin resistance, disease severity, clinical complications, and prognosis in patients with chronic liver diseases. Am J Gastroenterol 2006;101:1244-52.
41. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999;94:2467-74.