Heritability of the weight loss response to gastric bypass surgery

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 10, 2011, Pages

  Hatoum, Ida J ^a,b   Greenawalt, Danielle M ^c   Cotsapas, Chris ^a,b,d   Reitman, Marc L ^c   Daly, Mark J ^a,b   Kaplan, Lee M ^a,b,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; COITUS; FEMALE; GENETIC ASSOCIATION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RELATIVE; ROUX EN Y GASTRIC BYPASS; STOMACH BYPASS; TREATMENT RESPONSE; WEIGHT REDUCTION;

ADULT; COHORT STUDIES; ENDPOINT DETERMINATION; FAMILY; FEMALE; GASTRIC BYPASS; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OBESITY; STOMACH; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 80053473249     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-1130     Document Type: Article

References (18)

1. O'Rahilly S, Farooqi IS 2008 Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions. Diabetes 57:2905-2910
2. Wing RR 2010 Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med 170:1566-1575
3. Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC 2007 Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the ATOZ Weight Loss Study: a randomized trial. JAMA 297:969-977 (Pubitemid 46376751)
4. Bray GA 2008 Medications for weight reduction. Endocrinol Metab Clin North Am 37:923-942
5. Kaplan LM 2010 Pharmacologic therapies for obesity. Gastroenterol Clin North Am 39:69-79
6. Stylopoulos N, Hoppin AG, Kaplan LM 2009 Roux-en-Y gastric bypass enhances energy expenditure and extends lifespan in diet induced obese rats. Obesity 17:1839-1847
7. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K 2004 Bariatric surgery: a systematic review and meta-analysis. JAMA 292:1724-1737 (Pubitemid 39346675)
8. Rubino F, Gagner M, Gentileschi P, Kini S, Fukuyama S, Feng J, Diamond E 2004 The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism. Ann Surg 240:236-242 (Pubitemid 38963013)
9. Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM 2007 Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 357:741-752 (Pubitemid 47295641)
10. Hatoum IJ, Stein HK, Merrifield BF, Kaplan LM 2009 Capacity for physical activity predicts weight loss after Roux-en-Y gastric bypass. Obesity 17:92-99 (Pubitemid 50324545)
11. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D 2006 Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-909 (Pubitemid 44141658)
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, De Bakker PI, Daly MJ, Sham PC 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575 (Pubitemid 47330214)
13. Hagedorn JC, Morton JM 2007 Nature versus nurture: identical twins and bariatric surgery. Obes Surg 17:728-731 (Pubitemid 46999034)
14. Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjöström L, Bouchard C, Carlsson LM 2011 Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes (Lond) 35:676-683
15. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C 2011 Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg 21:930-934
16. Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T, Carey DJ, Gerhard GS 10 February 2011 High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery. Obesity 19:1676-1683
17. Kaplan LM 2003 Body weight regulation and obesity. J Gastrointest Surg 7:443-451 (Pubitemid 36877181)
18. MacLean PS, Higgins JA, Johnson GC, Fleming-Elder BK, Donahoo WT, Melanson EL, Hill JO 2004 Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 287:R1306-R1315 (Pubitemid 39532213)