Association between MTHFR C677T genotype and circulating folate levels irrespective of folate intake: Data from the IMMIDIET Project

Nutrition

Volumn 27, Issue 11-12, 2011, Pages 1209-1210

  Vohnout, Branislav ^a,b   Arnout, Jozef ^c   Krogh, Vittorio ^d   Donati, Maria Benedetta ^a   de Gaetano, Giovanni ^a   Iacoviello, Licia ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYSTEINE; DNA; FOLIC ACID; HOMOCYSTEINE; THYMINE;

ADULT; AGE; BODY MASS; CHEMOLUMINESCENCE; CIGARETTE SMOKING; CONTROLLED STUDY; DNA METHYLATION; EATING HABIT; ETHNIC GROUP; FEMALE; FOLIC ACID BLOOD LEVEL; FOOD FREQUENCY QUESTIONNAIRE; FOOD INTAKE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; ITALIAN; LETTER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; WAIST HIP RATIO;

FOLIC ACID; GENOTYPE; HOMOCYSTEINE; HUMANS; ITALY; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC;

EID: 80053459760     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2011.07.008     Document Type: Letter

References (10)

1. Stover P.J. Physiology of folate and vitamin B12 in health and disease. Nutr Rev 2004, 62:S3-S12.
2. Botto L.D., Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 2000, 151:862-877.
3. van der Put N.M., Steegers-Theunissen R.P., Frosst P., Trijbels F.J., Eskes T.K., van den Heuvel L.P., et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 1995, 346:1070-1071.
4. Ma J., Stampfer M.J., Hennekens C.H., Frosst P., Selhub J., Horsford J., et al. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. Circulation 1996, 94:2410-2416.
5. Gori A.M., Sofi F., Corsi A.M., Gazzini A., Sestini I., Laurentani F., et al. Predictors of Vitamin B6 and folate concentrations in older persons: the InCHIANTI Study. Clin Chem 2006, 52:1318-1324.
6. Nishio K., Goto Y., Kondo T., Ito S., Ishida Y., Kawai S., et al. Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake. J Epidemiol 2008, 18:125-131.
7. Iacoviello L., Arnout J., Buntinx F., Cappuccio F.P., Dagnelie P.C., de Lorgeril M., et al. Dietary habit profile in European communities with different risk of myocardial infarction: the impact of migration as a model of gene-environment interaction. The IMMIDIET Study. Nutr Metab Cardiovasc Dis 2001, 11(4 suppl):122-126. European Collaborative Group of the IMMIDIET Project.
8. di Giuseppe R., de Lorgeril M., Salen P., Laporte F., Di Castelnuovo A., Krogh V., et al. Alcohol consumption and n-3 polyunsaturated fatty acids in healthy men and women from 3 European populations. Am J Clin Nutr 2009, 89:354-362. European Collaborative Group of the IMMIDIET Project.
9. Pisani P., Faggiano F., Krogh V., Palli D., Vineis P., Berrino F. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int J Epidemiol 1997, 26(suppl 1):S152-S160.
10. de Bree A., Verschuren W.M., Bjørke-Monsen A.L., van der Put N.M., Heil S.G., Trijbels F.J., et al. Effect of the methylenetetrahydrofolate reductase 677C → T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 2003, 77:687-693.