Preparation and evaluation of 5, 9-dimethyl-2-cyclopropyl-2-decanol as a penetration enhancer for drugs through rat skin

Pakistan Journal of Pharmaceutical Sciences

Volumn 24, Issue 4, 2011, Pages 451-457

  Khan, Gul Majid ^a   Hussain, Abid ^a   Hanif, Raja Muhammad ^b  

^a GOMAL UNIVERSITY   (Pakistan)

^b Ministry of Health   (Pakistan)

Author keywords

5 Fluorouracil; Permeation enhancers; Preparation of 5,9 dimethyl 2 cyclopropyl 2 decanol; Tetrahydrogeraniol; Tramadol hydrochloride

Indexed keywords

3,7 DIMETHYLOCTANOL; 5,9 DIMETHYL 2 CYCLOPROPYL 2 DECANOL; FLUOROURACIL; LAUROCAPRAM; PENETRATION ENHANCING AGENT; TRAMADOL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GAS CHROMATOGRAPHY; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTITION COEFFICIENT; RAT; SKIN; SKIN PENETRATION; STRATUM CORNEUM;

ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, TOPICAL; ANIMALS; AZEPINES; CYCLOPROPANES; DIFFUSION; FATTY ALCOHOLS; FLUOROURACIL; KINETICS; MALE; MOLECULAR STRUCTURE; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; TERPENES; TRAMADOL;

EID: 80053443864     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Abdullah D, Ping QN and Liu GJ (1996). Enhancing effect of eucalyptus oil and its β-cyclodextrin complex on the penetration of 5-fluorouracil through excised rat skin. J. China Pharm. Univ., 27(2): 77-83.
2. th ed., Pearson Education Limited, Essex England. p.434.
3. Brevet of Invention No. 1.213.486 (1960). New alcohols with isoprene chains and their preparation. Rhone-Poulenc Chemical Company, France.
4. Cheon KL, Takahero U and Kazuhisa K (1994). Skin permeability of various drugs with lipophilicity. J. Pharm. Sci., 83: 562-565.
5. Chow D, Tenjarala S, Tsui M, Asici S and Hsieh D (1998). SAR of enhancers with enhancing strength on drug permeation and structural perturbation in stratum corneum. Proceed. Int. Symp. Contr. Rel. Bioact. Mater., 15: 85-86.
6. th ed., London, Bailliere Tindal, pp.424-429.
7. Femenía-Font A, Balaguer-Fernández C, Merino V, Rodilla V and López-Castellano A (2005). Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate. Eur. J. Pharm. Biopharm., 61(1-2): 50-55.
8. Fuhrman JC, Mickniak BB and Behl CR (1997). Effect of novel penetration enhancers on the transdermal delivery of hydrocortisone: an in vitro species comparison. J. Control. Rel., 45(2): 199-206.
9. George WC, Ray CE and Joseph RL (1963). Organic Synthesis Collective. Vol. IV, John Wiley and Sons, New York, pp.597-600.
10. Ghafourian T, Zandasrar P, Hamishekar H and Nokhodchi A (2004). The effect of penetration enhancers on drug delivery through skin: A QSAR study. J. Contr. Rel., 99(1): 113-125. (Pubitemid 39165738)
11. Hanif R, Ping QN and Liu GJ (1997). Enhancing effect of on the permeation of 5-fluorouracil through excised rat skin. J. China Pharm. Univ., 28(4): 206-209.
12. Hanif R, Ping QN and Fenzhu M (1998). Enhancing effect of 4,8-Dimethyl-1-Nonanol on the transepidermal delivery of 5-fluorouracil and tramadol hydrochloride. J. China Pharm. Univ., 29(3): 170-175.
13. 3-Me/IPP): An in vitro evaluation using oestradiol. Drug Dev. Ind. Pharm., 23: 9-15.
14. Lim PFC, Liu XY, Kang L, Ho PCL, Chan YW and Chan SY (2006). Limonene GP1/PG organo-gel as a vehicle in transdermal delivery of haloperidol. Int. J. Pharm., 311(1-2): 157-164.
15. Morimoto Y, Sugibayashi K, Hosoya K and Huguchi WI (1986). Penetration enhancing effect of Azone on the transport of 5-FU across hairless rat skin. Int. J. Pharm., 32: 31-38. (Pubitemid 16038932)
16. Small DM (1984). Lateral chain packing in lipids and membranes. J. Lipid Res., 25: 1490-1500.
17. Walker RB and Smith EW (1996). The role of percutaneous penetration enhancers. Adv. Drug Del. Rev., 18: 295-301. (Pubitemid 26063305)
18. William AC and Barry BW (1989a). Permeation, FTIR and DSC investigation of terpene penetration enhancers in human skin. J. Pharm. Pharmacol., 41(Suppl.): 12.
19. William AC and Barry BW (1989b). Essential oils as novel human skin penetration enhancers. Int. J. Pharm., 57: R7-R9.
20. William AC and Barry BW (1991a). The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophilic (5-fluorouracil) drugs. Int. J. Pharm., 74: 157-168.
21. William AC and Barry BW (1991b). Terpenes and lipid-protein-partitioning theory of skin penetration enhancement. Pharm. Res., 8: 17-24.
22. Yamane MA and William AC and Barry BW (1995). Terpene penetration enhancers in propylene glycol/water co-solvent systems: Effectiveness and mechanism if action. J. Pharm. Pharmacol., 47: 978-989. (Pubitemid 26048166)