Maturation-induced cloaking of neutralization epitopes on hiv-1 particles

PLoS Pathogens

Volumn 7, Issue 9, 2011, Pages

  Joyner, Amanda S ^a   Willis, Jordan R ^a   Crowe Jr , James E ^a   Aiken, Christopher ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN GP 41; MONOCLONAL ANTIBODY; VIRUS ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NEUTRALIZING ANTIBODY;

ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOFLUORESCENCE; MATURATION; MEMBRANE PROXIMAL EXTERNAL REGION; NONHUMAN; PROTEIN CONFORMATION; PROTEIN STRUCTURE; VIROGENESIS; VIRUS PARTICLE; CD4+ T LYMPHOCYTE; CELL LINE; ENVELOPE GENE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNE EVASION; IMMUNOBLOTTING; IMMUNOLOGY; METHODOLOGY; SERODIAGNOSIS; VIRION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, VIRAL; GENES, ENV; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; IMMUNE EVASION; IMMUNOBLOTTING; NEUTRALIZATION TESTS; VIRION;

EID: 80053440098     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002234     Document Type: Article

References (29)

1. Hoxie JA, (2010) Toward an antibody-based HIV-1 vaccine. Annu Rev Med 61: 135-152.
2. Hunter E, Swanstrom R, (1990) Retrovirus envelope glycoproteins. Curr Top Microbiol Immunol 157: 187-253.
3. Lodge R, Lalonde JP, Lemay G, Cohen EA, (1997) The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cells. EMBO J 16: 695-705.
4. Rowell JF, Stanhope PE, Siliciano RF, (1995) Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC. J Immunol 155: 473-488.
5. Egan MA, Carruth LM, Rowell JF, Yu X, Siliciano RF, (1996) Human immunodeficiency virus type 1 envelope protein endocytosis mediated by a highly conserved intrinsic internalization signal in the cytoplasmic domain of gp41 is suppressed in the presence of the Pr55gag precursor protein. J Virol 70: 6547-6556.
6. Freed EO, Martin MA, (1996) Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions. J Virol 70: 341-351.
7. Freed EO, Martin MA, (1995) Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix. J Virol 69: 1984-1989.
8. Wyma DJ, Kotov A, Aiken C, (2000) Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles. J Virol 74: 9381-9387.
9. Cosson P, (1996) Direct interaction between the envelope and matrix proteins of HIV-1. EMBO J 15: 5783-5788.
10. Vogt VM, (1996) Proteolytic processing and particle maturation. Curr Top Microbiol Immunol 214: 95-131.
11. Wyma DJ, Jiang J, Shi J, Zhou J, Lineberger JE, et al. (2004) Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. J Virol 78: 3429-3435.
12. Jiang J, Aiken C, (2007) Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail. J Virol 81: 9999-10008.
13. Murakami T, Ablan S, Freed EO, Tanaka Y, (2004) Regulation of human immunodeficiency virus type 1 Env-mediated membrane fusion by viral protease activity. J Virol 78: 1026-1031.
14. Kol N, Shi Y, Tsvitov M, Barlam D, Shneck RZ, et al. (2007) A stiffness switch in human immunodeficiency virus. Biophys J 92: 1777-1783.
15. Edwards TG, Wyss S, Reeves JD, Zolla-Pazner S, Hoxie JA, et al. (2002) Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope protein. J Virol 76: 2683-2691.
16. Spies CP, Ritter GD Jr, Mulligan MJ, Compans RW, (1994) Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein alters the conformation of the external domain. J Virol 68: 585-591.
17. Mulligan MJ, Yamshchikov GV, Ritter GD Jr, Gao F, Jin MJ, et al. (1992) Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types. J Virol 66: 3971-3975.
18. Zhu P, Chertova E, Bess J Jr, Lifson JD, Arthur LO, et al. (2003) Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc Natl Acad Sci U S A 100: 15812-15817.
19. Trkola A, Purtscher M, Muster T, Ballaun C, Buchacher A, et al. (1996) Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1. J Virol 70: 1100-1108.
20. Hammonds J, Chen X, Ding L, Fouts T, De Vico A, et al. (2003) Gp120 stability on HIV-1 virions and Gag-Env pseudovirions is enhanced by an uncleaved Gag core. Virology 314: 636-649.
21. Rizzuto CD, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, et al. (1998) A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280: 1949-1953.
22. Sullivan N, Sun Y, Sattentau Q, Thali M, Wu D, et al. (1998) CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization. J Virol 72: 4694-4703.
23. Chen CH, Greenberg ML, Bolognesi DP, Matthews TJ, (2000) Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41. AIDS Res Hum Retroviruses 16: 2037-2041.
24. Dimitrov AS, Louis JM, Bewley CA, Clore GM, Blumenthal R, (2005) Conformational changes in HIV-1 gp41 in the course of HIV-1 envelope glycoprotein-mediated fusion and inactivation. Biochemistry 44: 12471-12479.
25. Jiang J, Aiken C, (2006) Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages. Virology 346: 460-468.
26. McDonald D, Vodicka MA, Lucero G, Svitkina TM, Borisy GG, et al. (2002) Visualization of the intracellular behavior of HIV in living cells. J Cell Biol 159: 441-452.
27. Chen C, Okayama H, (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745-2752.
28. Wehrly K, Chesebro B, (1997) p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagents. Methods 12: 288-293.
29. Hicar MD, Chen X, Briney B, Hammonds J, Wang JJ, et al. (2010) Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV. J Acquir Immune Defic Syndr 54: 223-235.