The effects of inhomogeneous boundary dilution on the coating flow of an anti-HIV microbicide vehicle

Physics of Fluids

Volumn 23, Issue 9, 2011, Pages

  Tasoglu, Savas ^a   Peters, Jennifer J ^b   Park, Su Chan ^a,c   Verguet, Stéphane ^a,d   Katz, David F ^b   Szeri, Andrew J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b USA   (United States)

^c LG   (South Korea)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOUNDARY LAYERS; COATINGS; DIFFUSION IN LIQUIDS; DRUG DELIVERY; ELASTOHYDRODYNAMIC LUBRICATION; GELS; RHEOLOGY; SHEAR THINNING;

ANTI-HIV MICROBICIDE; ANTIRETROVIRAL DRUGS; CONSTITUTIVE PARAMETERS; DIFFUSIVE TRANSPORT; HIV TRANSMISSION; RHEOLOGICAL BEHAVIORS; RHEOLOGICAL PROPERTY; TISSUE INTERFACE;

DILUTION;

EID: 80053417138     PISSN: 10706631     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.3633337     Document Type: Article

References (32)

1. Jin Z.M. Dowson D. Elastohydrodynamic lubrication in biological systems. Proc. Inst. Mech. Eng., Part J: J. Eng. Tribol. 2005, 219:367. 10.1243/135065005X33982.
2. Lighthill M.J. Pressure-forcing of tightly fitting pellets along fluid-filled elastic tubes. J. Fluid Mech. 1968, 34:113. 10.1017/S0022112068001795.
3. Holly F.J. Holly T.F. Lacrimal Gland, Tear Film, and Dry Eye Syndromes 1994, D. A. Sullivan, and in edited by Plenum, New York).
4. Jones M.B. Fulford G.R. Please C.P. McElwain D.L. S. Collins M.J. Elastohydrodynamics of the eyelid wiper. Bull. Math. Biol. 2008, 70:323. 10.1007/s11538-007-9252-7.
5. Gouldstone A. Brown R.E. Butler J.P. Loring S.H. Elastohydrodynamic separation of pleural surfaces during breathing. Respir. Physiol. Neurbiol. 2003, 137:97. 10.1016/S1569-9048(03)00138-1.
6. Stone A. Microbicides: A new approach to preventing HIV and other sexually transmitted infections. Nature Rev. Drug Discovery 2002, 1:977. 10.1038/nrd959.
7. McGowan I. Microbicides: A new frontier in HIV prevention. Biologicals 2006, 34:241. 10.1016/j.biologicals.2006.08.002.
8. Vermani K. Garg S. The scope and potential of vaginal drug delivery. Pharm. Sci. Technol. Today 2000, 3:359. 10.1016/S1461-5347(00)00296-0.
9. Harrison P.F. Rosenberg Z. Bowcut J. Topical microbicides for disease prevention: Status and challenges. Clin. Infect. Dis. 2003, 36:1290. 10.1086/374834.
10. D'Cruz O.J. Uckun F.M. Clinical development of microbicides for the prevention of HIV infection. Curr. Pharm. Des. 2004, 10:315. 10.2174/1381612043386374.
11. Karim Q.A. Karim S.S. A. Frohlich J.A. Grobler A.C. Baxter C. Mansoor L.E. Kharsany A.B. M. Sibeko S. Mlisana K.P. Omar Z. Gengiah T.N. Maarschalk S. Arulappan N. Mlotshwa M. Morris L. Taylor D. Effectiveness and safety of Tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010, 329:1168. 10.1126/science.1193748.
12. Verguet S. Holt B.Y. Szeri A.J. Increasing the effectiveness of vaginal microbicides: A biophysical framework to rethink behavioral acceptability. PLoS ONE 2010, 5:11. 10.1371/journal.pone.0015501.g001.
13. Katz D.F. Henderson M. Owen D.H. Plenys A.M. Walmer D.K. What is needed to advance vaginal formulation technology?. Vaginal Microbicide Formulations Workshop 1998 in Lippencott-Raven, Philadelphia).
14. Kieweg S.L. Geonnotti A.R. Katz D.F. Gravity-induced coating flows of vaginal gel formulations: In vitro experimental analysis. J. Pharm. Sci. 2004, 93:2941. 10.1002/jps.v93:12.
15. Kieweg S.L. Katz D.F. Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery. J. Biomech. Eng. 2006, 128:540. 10.1115/1.2206198.
16. Kieweg S.L. Katz D.F. Interpreting properties of microbicide drug delivery gels: Analyzing deployment due to squeezing. J. Pharm. Sci. 2007, 96:835. 10.1002/jps.v96:4.
17. Lai B.E. Xie Y.Q. Lavine M. Szeri A.J. Owen D.H. Katz D.F. Dilution of microbicide gels with vaginal fluid and semen simulants: Effects on rheology and coating flow. J. Pharm. Sci. 2008, 97:1030. 10.1002/jps.v97:2.
18. Szeri A.J. Park S.C. Verguet S. Weiss A. Katz D.F. A model of transluminal flow of an anti-HIV microbicide vehicle: Combined elastic squeezing and gravitational sliding. Phys. Fluids 2008, 20:083101. 10.1063/1.2973188.
19. Crosby B.J. Mangnus M. de Groot W. Daniels R. McLeish T.C. B. Characterization of long chain branching: Dilution-rheology of industrial polyethylenes. J. Rheology 2002, 46:401. 10.1122/1.1451083.
20. Dealy J.M. Larson R.G. Structure and Rheology of Molten Polymers 2006, and (Hanser Publications, Cincinnati, OH).
21. Owen D.H. Peters J.J. Katz D.F. Rheological properties of contraceptive gels. Contraception 2000, 62:321. 10.1016/S0010-7824(00)00184-0.
22. Roy S. Barrier Contraceptives: Current Status and Future Prospects 1994, (Wiley, New York).
23. Coyle D.J. Forward roll coating with deformable rolls: A simple one dimensional elastohydrodynamic model. Chem. Eng. Sci. 1988, 43:2673. 10.1016/0009-2509(88)80011-3.
24. Owen D.H. Katz D.F. A vaginal fluid stimulant. Contraception 1999, 59:91. 10.1016/S0010-7824(99)00010-4.
25. Crank J.A. Theoretical investigation of the influence of molecular relaxation and internal stress on diffusion in polymers. J. Polym. Sci. 1953, 11:151. 10.1002/pol.1953.120110206.
26. Podual K. Doyle F. Peppas N.A. Modeling of water transport in and release from glucose-sensitive swelling-controlled release systems based on Poly (Diethylaminoethyl Methacrylate-g-Ethylene Glycol). Ind. Eng. Chem. Res. 2004, 43:7500. 10.1021/ie0497238.
27. Verguet S. Transport phenomena in microfluidics and microbicide drug delivery systems. 2008 Ph.D. dissertation, University of California, Berkeley.
28. Syrnikov Y.P. Calculation of the self-diffusion coefficient of water. J. Struct. Chem. 1970, 11:698. 10.1007/BF00743446.
29. Acarturk F. Robinson J.R. Vaginal permeability and enzymatic activity studies in normal and ovariectomized rabbits. Pharm. Res. 1996, 13:5. 10.1023/A:1016016120392.
30. Kremer M. Squier C. Schlievert P. Davis C. Permeability of vaginal mucosa to toxic shock syndrome Toxin-1. Abstr. Intersci. Conf. Antimicrob. Agents Chemother. 2001, 41. and Abstract No. B-959.
31. Mahalingam A. Smith E. Fabian J. Damian F.R. Peters J.J. Clark M.R. Friend D.R. Katz D.F. Kiser P.F. Design of a semisolid vaginal microbicide gel by relating composition to properties and performance. Pharm. Res. 2010, 27:2478. 10.1007/s11095-010-0244-1.
32. Schuenke M. Schulte E. Ross L.M. Schumacher U. Lamperti E.D. Atlas of Anatomy: Neck and Internal Organs 2010, 250. (Thieme, New York)