메뉴 건너뛰기




Volumn 61, Issue 9, 2011, Pages 515-520

Suppressive effects of the antiandrogen agent, chlormadinone acetate and the 5α-reductase inhibitor, dutasteride on prostate weight and intraprostatic androgen levels in rats

Author keywords

Benign prostatic hyperplasia; Chlormadinone acetate; Dihydrotestosterone; Dutasteride; Rat prostate; Testosterone

Indexed keywords

ANDROGEN; ANDROSTANOLONE; CHLORMADINONE ACETATE; DUTASTERIDE; TESTOSTERONE;

EID: 80053409551     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296237     Document Type: Article
Times cited : (2)

References (33)
  • 1
    • 0031134477 scopus 로고    scopus 로고
    • Epidemiology and Natural History of Benign Prostatic Hyperplasia
    • Tsukamoto T, Masumori N. Epidemiology and natural history of benign prostatic hyperplasia. Int J Urol. 1997;4:233-46. (Pubitemid 127494959)
    • (1997) International Journal of Urology , vol.4 , Issue.3 , pp. 233-246
    • Tsukamoto, T.1    Masumori, N.2
  • 2
    • 33847239396 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia: An overview
    • Roehrborn CG. Benign prostatic hyperplasia: an overview. Rev Urol. 2005;7:S3-14.
    • (2005) Rev Urol. , vol.7
    • Roehrborn, C.G.1
  • 3
    • 53749101119 scopus 로고    scopus 로고
    • Current role of alpha-blockers in the treatment of benign prostatic hyperplasia
    • Kaplan SA. Current role of alpha-blockers in the treatment of benign prostatic hyperplasia. BJU Int. 2008;102(S2):3-7.
    • (2008) BJU Int. , vol.102 , Issue.2 , pp. 3-7
    • Kaplan, S.A.1
  • 4
    • 0032840740 scopus 로고    scopus 로고
    • Alpha-1-adrenoceptor blockade in the treatment of benign prostatic hyperplasia
    • Lowe F. Alpha-1-adrenoceptor blockade in the treatment of benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 1999;2:110-9. (Pubitemid 29438918)
    • (1999) Prostate Cancer and Prostatic Diseases , vol.2 , Issue.3 , pp. 110-119
    • Lowe, F.1
  • 5
    • 0026333713 scopus 로고
    • Antiandrogen therapy of benign prostatic hyperplasia-review of the agents evaluation of the clinical results
    • Kanimoto Y, Okada K. Antiandrogen therapy of benign prostatic hyperplasia-review of the agents evaluation of the clinical results. Hinyokika Kiyo. 1991;37:1423-8.
    • (1991) Hinyokika Kiyo. , vol.37 , pp. 1423-1428
    • Kanimoto, Y.1    Okada, K.2
  • 8
    • 0037252187 scopus 로고    scopus 로고
    • Effects of combination therapy with a luteinizing hormone-releasing hormone agonist and chlormadinone acetate on rat prostate weight and plasma testosterone levels
    • DOI 10.1038/sj.pcan.4500617
    • Gotanda K, Shinbo A, Okada M, Nakano Y, Kobayashi H, Sasaki T, et al. Effects of combination therapy with a luteinizing hormone-releasing hormone agonist and chlormadinone acetate on rat prostate weight and plasma testosterone levels. Prostate Cancer Prostatic Dis. 2003;6:66-72. (Pubitemid 36432624)
    • (2003) Prostate Cancer and Prostatic Diseases , vol.6 , Issue.1 , pp. 66-72
    • Gotanda, K.1    Shinbo, A.2    Okada, M.3    Nakano, Y.4    Kobayashi, H.5    Sasaki, T.6    Hagiwara, M.7    Akaza, H.8
  • 9
    • 0029840529 scopus 로고    scopus 로고
    • Relative potency of antiandrogens with reference to intracellular testosterone in the rat prostate
    • DOI 10.1002/(SICI)1097-0045(199609)29:3<146::AID-PROS1>3.0.CO;2-C
    • Kondo Y, Homma Y, Aso Y, Kawabe K, Mieda M, Takahashi H. Relative potency of antiandrogens with reference to intracellular testosterone in the rat prostate. Prostate. 1996;29:146-52. (Pubitemid 26341819)
    • (1996) Prostate , vol.29 , Issue.3 , pp. 146-152
    • Kondo, Y.1    Homma, Y.2    Aso, Y.3    Kawabe, K.4    Mieda, M.5    Takahashi, H.6
  • 10
    • 0034747693 scopus 로고    scopus 로고
    • Comparison of histological compositions and apoptosis in canine spontaneous benign prostatic hyperplasia treated with androgen suppressive agents chlormadinone acetate and finasteride
    • Shibata Y, Fukabori Y, Ito K, Suzuki K, Yamanaka H. Comparison of histological compositions and apoptosis in canine spontaneous benign prostatic hyperplasia treated with androgen suppressive agents chlormadinone acetate and finasteride. J Urol. 2001;165:289-93.
    • (2001) J Urol. , vol.165 , pp. 289-293
    • Shibata, Y.1    Fukabori, Y.2    Ito, K.3    Suzuki, K.4    Yamanaka, H.5
  • 12
    • 43549124856 scopus 로고    scopus 로고
    • Dutasteride significantly improves quality of life measures in patients with enlarged prostate
    • DOI 10.1038/sj.pcan.4500990, PII 4500990
    • O'Leary MP, Roehrborn CG, Black L. Dutasteride significantly improves quality of life measures in patients with enlarged prostate. Prostate Cancer Prostatic Dis. 2008;11: 129-33. (Pubitemid 351676599)
    • (2008) Prostate Cancer and Prostatic Diseases , vol.11 , Issue.2 , pp. 129-133
    • O'Leary, M.P.1    Roehrborn, C.G.2    Black, L.3
  • 13
    • 4444336295 scopus 로고    scopus 로고
    • Efficacy and safety of long-term treatment with the dual 5alpha-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia
    • DOI 10.1016/j.eururo.2004.05.008, PII S0302283804003240
    • Debruyne F, Barkin J, van Erps P, Reis M, Tammela TL, Roehrborn C; ARIA3001, ARIA3002 and ARIB3003 Study Investigators. Efficacy and safety of long-termtreatment with the dual 5 alpha-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia. Eur Urol. 2004;46:488-95. (Pubitemid 39200858)
    • (2004) European Urology , vol.46 , Issue.4 , pp. 488-495
    • Debruyne, F.1    Barkin, J.2    Erps, P.V.3    Reis, M.4    Tammela, T.L.J.5    Roehrborn, C.6
  • 14
    • 1842688886 scopus 로고    scopus 로고
    • Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia
    • DOI 10.1016/j.urology.2004.01.001, PII S0090429504000688
    • Roehrborn CG, Marks LS, Fenter T, Freedman S, Tuttle J, Gittleman M, et al. Efficacy and safety of dutasteride in the four-year treatment of men with benign prostatic hyperplasia. Urology. 2004;63:709-15. (Pubitemid 38479415)
    • (2004) Urology , vol.63 , Issue.4 , pp. 709-715
    • Roehrborn, C.G.1    Marks, L.S.2    Fenter, T.3    Freedman, S.4    Tuttle, J.5    Gittleman, M.6    Morrill, B.7    Wolford, E.T.8
  • 15
    • 52949132642 scopus 로고    scopus 로고
    • Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer
    • Rittmaster R, Hahn RG, Ray P, Shannon JB, Wurzel R. Effect of dutasteride on intraprostatic androgen levels in men with benign prostatic hyperplasia or prostate cancer. Urology. 2008;72:808-12.
    • (2008) Urology. , vol.72 , pp. 808-812
    • Rittmaster, R.1    Hahn, R.G.2    Ray, P.3    Shannon, J.B.4    Wurzel, R.5
  • 16
    • 34249989027 scopus 로고    scopus 로고
    • The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
    • DOI 10.1038/sj.pcan.4500931, PII 4500931
    • Wurzel R, Ray P, Major-Walker K, Shannon J, Rittmaster R. The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 2007;10:149-54. (Pubitemid 46881666)
    • (2007) Prostate Cancer and Prostatic Diseases , vol.10 , Issue.2 , pp. 149-154
    • Wurzel, R.1    Ray, P.2    Major-Walker, K.3    Shannon, J.4    Rittmaster, R.5
  • 17
    • 0037203496 scopus 로고    scopus 로고
    • Evaluation of androgenic bioactivity in human serum by recombinant cell line: Preliminary results
    • DOI 10.1016/S0303-7207(02)00375-1, PII S0303720702003751
    • Paris F, Servant N, Térouanne B, Sultan C. Evaluation of androgenic bioactivity in human serum by recombinant cell line: preliminary results. Mol Cell Endocrinol. 2002; 198:123-9. (Pubitemid 36169942)
    • (2002) Molecular and Cellular Endocrinology , vol.198 , Issue.1-2 , pp. 123-129
    • Paris, F.1    Servant, N.2    Terouanne, B.3    Sultan, C.4
  • 18
    • 0032935119 scopus 로고    scopus 로고
    • Distinguishing androgen receptor agonists and antagonists: Distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone
    • Kemppainen JA, Langley E, Wong CI, Bobseine K, Kelce WR, Wilson EM. Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone. Mol Endocrinol. 1999;13:440-54. (Pubitemid 29113876)
    • (1999) Molecular Endocrinology , vol.13 , Issue.3 , pp. 440-454
    • Kemppainen, J.A.1    Langley, E.2    Wong, C.-I.3    Bobseine, K.4    Kelce, W.R.5    Wilson, E.M.6
  • 19
    • 33846347711 scopus 로고    scopus 로고
    • The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay
    • DOI 10.1021/bi061321b
    • Ozers MS, Marks BD, Gowda K, Kupcho KR, Ervin KM, De Rosier T, et al. The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wildtype androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Biochemistry. 2007;46:683-95. (Pubitemid 46133586)
    • (2007) Biochemistry , vol.46 , Issue.3 , pp. 683-695
    • Ozers, M.S.1    Marks, B.D.2    Gowda, K.3    Kupcho, K.R.4    Ervin, K.M.5    De Rosier, T.6    Qadir, N.7    Eliason, H.C.8    Riddle, S.M.9    Shekhani, M.S.10
  • 20
    • 0742287752 scopus 로고    scopus 로고
    • Dutasteride, the Dual 5alpha-Reductase Inhibitor, Inhibits Androgen Action and Promotes Cell Death in the LNCaP Prostate Cancer Cell Line
    • DOI 10.1002/pros.10340
    • Lazier CB, Thomas LN, Douglas RC, Vessey JP, Rittmaster RS. Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004;58:130-44. (Pubitemid 38160900)
    • (2004) Prostate , vol.58 , Issue.2 , pp. 130-144
    • Lazier, C.B.1    Thomas, L.N.2    Douglas, R.C.3    Vessey, J.P.4    Rittmaster, R.S.5
  • 21
    • 0033989357 scopus 로고    scopus 로고
    • Changes in the endocrine environment of the human prostate transition zone with aging: Simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition
    • DOI 10.1002/(SICI)1097-0045(20000101)42:1<45::AID-PROS6>3.0.CO;2-W
    • Shibata Y, Ito K, Suzuki, K, Nakano K, Fukabori Y, Suzuki R, et al. Changes in the endocrine environment of the human prostate transition zone with aging: Simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition. Prostate. 2000;42:45-55. (Pubitemid 30004874)
    • (2000) Prostate , vol.42 , Issue.1 , pp. 45-55
    • Shibata, Y.1    Ito, K.2    Suzuki, K.3    Nakano, K.4    Fukabori, Y.5    Suzuki, R.6    Kawabe, Y.7    Honma, S.8    Yamanaka, H.9
  • 23
    • 21744434634 scopus 로고
    • Phase III study of 5 alpha-reductase inhibitor, MK-906 in patients with benign prostatic hyperplasia - A comparable double blind study with chlormadinone acetate long acting tablets
    • Japanese
    • Aso Y, Homma Y, Kumamoto Y, Tsukamoto T, Orikasa S, Yamanaka H et al. [Phase III study of 5 alpha-reductase inhibitor, MK-906 in patients with benign prostatic hyperplasia - A comparable double blind study with chlormadinone acetate long acting tablets]. Hinyoki Ge Ka. 1995;8:237-56. Japanese.
    • (1995) Hinyoki Ge Ka , vol.8 , pp. 237-256
    • Aso, Y.1    Homma, Y.2    Kumamoto, Y.3    Tsukamoto, T.4    Orikasa, S.5    Yamanaka, H.6
  • 25
    • 66249095157 scopus 로고    scopus 로고
    • Assessment of recommended dose of dutasteride on Japanese men with benign prostatic hyperplasia: A randomized, double-blind, place-bo-controlled, parallel-group, dose response study
    • Tsukamoto T, Endo Y, Narita M. Assessment of recommended dose of dutasteride on Japanese men with benign prostatic hyperplasia: a randomized, double-blind, place-bo-controlled, parallel-group, dose response study. Hinyokika Kiyo. 2009;55:209-14.
    • (2009) Hinyokika Kiyo. , vol.55 , pp. 209-214
    • Tsukamoto, T.1    Endo, Y.2    Narita, M.3
  • 26
    • 70349245242 scopus 로고    scopus 로고
    • Efficacy and safety of dutasteride in Japanese men with benign prostatic hyperplasia
    • Tsukamoto T, Endo Y, Narita M. Efficacy and safety of dutasteride in Japanese men with benign prostatic hyperplasia. Int J Urol. 2009;16:745-50.
    • (2009) Int J Urol. , vol.16 , pp. 745-750
    • Tsukamoto, T.1    Endo, Y.2    Narita, M.3
  • 27
    • 0026443794 scopus 로고
    • Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors
    • Cunha GR, Alarid ET, Turner T, Donjacour AA, Boutin EL, Foster BA. Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors. J Androl. 1992;13: 465-75.
    • (1992) J Androl. , vol.13 , pp. 465-475
    • Cunha, G.R.1    Alarid, E.T.2    Turner, T.3    Donjacour, A.A.4    Boutin, E.L.5    Foster, B.A.6
  • 28
    • 0033777054 scopus 로고    scopus 로고
    • Effects of a new steroidal aromatase inhibitor, TZA- 2237, and/or chlormadinone acetate on hormone-induced and spontaneous canine benign prostatic hyperplasia
    • Ito K, Fukabori Y, Shibata Y, Suzuki K,MiedaM, Gotanda K, et al. Effects of a new steroidal aromatase inhibitor, TZA- 2237, and/or chlormadinone acetate on hormone-induced and spontaneous canine benign prostatic hyperplasia. Eur J Endocrinol. 2000;143:543-54.
    • (2000) Eur J Endocrinol. , vol.143 , pp. 543-554
    • Ito, K.1    Fukabori, Y.2    Shibata, Y.3    Suzuki, K.G.K.E.A.4
  • 31
    • 33748120911 scopus 로고    scopus 로고
    • Association Between the Dihydrotestosterone Level in the Prostate and Prostate Cancer Aggressiveness Using the Gleason Score
    • DOI 10.1016/j.juro.2006.06.066, PII S0022534706014467
    • Nishiyama T, Ikarashi T, Hashimoto Y, Suzuki K, Takahashi K. Association between the dihydrotestosterone level in the prostate and prostate cancer aggressiveness using the Gleason score. J Urol. 2006;176:1387-91. (Pubitemid 44307234)
    • (2006) Journal of Urology , vol.176 , Issue.4 , pp. 1387-1391
    • Nishiyama, T.1    Ikarashi, T.2    Hashimoto, Y.3    Suzuki, K.4    Takahashi, K.5
  • 32
    • 0022551509 scopus 로고
    • Pharmacology of an antiandrogen, anandron, used as an adjuvant therapy in the treatment of prostate cancer
    • DOI 10.1016/0022-4731(86)90043-9
    • Moguilewsky M, Fiet J, Tournemine C, Raynaud JP. Pharmacology of an antiandrogen, anandron, used as an adjuvant therapy in the treatment of prostate cancer. J Steroid Biochem. 1986;24:139-46. (Pubitemid 16047768)
    • (1986) Journal of Steroid Biochemistry , vol.24 , Issue.1 , pp. 139-146
    • Moguilewsky, M.1    Fiet, J.2    Tournemine, C.3    Raynaud, J.-P.4
  • 33
    • 33646102678 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and its metabolites: Differential effects on androgen receptor trafficking and transcriptional activity
    • Mo Q, Lu SF, Simon NG. Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity. J Steroid Biochem Mol Biol. 2006;99:50-8.
    • (2006) J Steroid Biochem Mol Biol. , vol.99 , pp. 50-58
    • Mo, Q.1    Lu, S.F.2    Simon, N.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.