Validation of an optical microplate label-free platform in the screening of chemical libraries for direct binding to a nuclear receptor

Assay and Drug Development Technologies

Volumn 9, Issue 5, 2011, Pages 532-548

  Vela, Laura ^a   Lowe, Peter N ^b   Gerstenmaier, John ^c   Laing, Lance G ^c,e   Stimmel, Julie B ^d   Orband Miller, Lisa A ^d   Martin, Julio J ^a  

^a GLAXOSMITHKLINE   (Spain)

^b Biomolecular Interactions Consultancy   (United Kingdom)

^c SRU Biosystems Inc   (United States)

^d GLAXOSMITHKLINE   (United States)

^e LGL Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; ESTROGEN RELATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SCREENING; LIGAND BINDING; MOLECULAR LIBRARY; OPTICAL BIOSENSOR; VALIDATION STUDY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BIOSENSING TECHNIQUES; BIOTINYLATION; CELL NUCLEUS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, THEORETICAL; MOLECULAR TARGETED THERAPY; NUCLEAR PROTEINS; OPTICAL PROCESSES; PEPTIDES; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; REPRODUCIBILITY OF RESULTS; SMALL MOLECULE LIBRARIES; STEREOISOMERISM;

EID: 80053345772     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2010.0345     Document Type: Article

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