Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium

Acta Pharmaceutica

Volumn 61, Issue 3, 2011, Pages 257-270

  Maiti, Sabyasachi ^a   Kaity, Santanu ^a   Ray, Somasree ^a   Sa, Biswanath ^b  

^a GUPTA COLLEGE OF TECHNOLOGICAL SCIENCES   (India)

^b JADAVPUR UNIVERSITY   (India)

Author keywords

diclofenac sodium; ethyl cellulose; microsponge; percutaneous delivery; W O W emulsion; xanthan gum

Indexed keywords

CARBOMER; DICLOFENAC; DRUG CARRIER; ETHYL CELLULOSE; MICROSPONGE; UNCLASSIFIED DRUG; WATER OIL CREAM; XANTHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; DISPERSION; DRUG DECOMPOSITION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG TRANSPORT; EMULSION; ERYTHEMA; GEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PARTICLE SIZE; POROSITY; RAT; SCANNING ELECTRON MICROSCOPY; SKIN; SKIN EDEMA; SKIN MANIFESTATION; SKIN PERMEABILITY;

EID: 80053343827     PISSN: 13300075     EISSN: 18469558     Source Type: Journal    
DOI: 10.2478/v10007-011-0022-6     Document Type: Article

References (19)

1. S. Saxena and S. Nacht, Polymeric Porous Delivery Systems: Polytrap® and Microsponge®, in Delivery System Handbook for Personal Care and Cosmetic Products: Technology, Applications and Formulations (Ed. M. R. Rosen), William Andrew Publishing, New York 2005, pp. 333-351.
2. S. Nacht and M. Katz, The Microsponge: A Novel Topical Programmable Delivery System, in Topical Drug Delivery Formulations (Ed. D. W. Osborne and A. H. Amman), Marcel Dekker, New York 1990, pp. 299-325.
3. N. Amrutiya, A. Bajaj and M. Madan, Development of microsponge for topical delivery of mupirocin, AAPS PharmSciTech. 10 (2009) 402-409; DOI: 10.1208/s12249-009-9220-7.
4. K. Embil and S. Nacht, The microsponge® delivery system (MDS): A topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives, J. Microencapsul. 13 (1996) 575-588; DOI: 10.3109/02652049609026042. (Pubitemid 26283810)
5. M. Orlu, E. Cevher and A. Araman, Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges, Int. J. Pharm. 318 (2006) 103-117; DOI: 10.1016/j.ijpharm.2006.03.025. (Pubitemid 43963308)
6. S. Annadurai, A. Basu, S. Ray, S. G. Dastidar and A. N. Chakrabarty. Antibacterial activity of the anti-inflammatory agent diclofenac sodium, Indian J. Exp. Biol. 36 (1998) 86-90. (Pubitemid 28063100)
7. A. Arellano, S. Santoyo, C. Martin and P. Ygartua, Influence of propylene glycol and isopropyl myristate on the in vitro percutaneous penetration of diclofenac sodium from carbopol gels, Eur. J. Pharm. Sci. 7 (1999) 129-135; DOI: 10.1016/S0928-0987(98)00010-4. (Pubitemid 29056235)
8. P. Hainey, I. M. Huxham, B. Rowatt, D. C. Sherrington and L. Tetley, Synthesis and ultrastructural studies of styrene-divinylbenzene polyhipe polymers, Macromolecules 24 (1991) 117-121; DOI: 10.1021/ma00001a019.
9. M. S. Muthu and S. Singh, Poly (d, l-lactide) nanosuspensions of risperidone for parenteral delivery: formulation and in-vitro evaluation, Curr. Drug Deliv. 6 (2009) 62-68; DOI: 10.2174/156720109787048302.
10. T. Higuchi, Rate of release of medicaments from ointment bases containing drugs in suspension, J. Pharm. Sci. 50 (1961) 874-875; DOI: 10.1002/jps.2600501018.
11. L. Panigrahi, S. K. Ghosal, S. Pattnaik, L. Maharana and B. B. Barik, Effect of permeation enhancers on the release and permeation kinetics of lincomycin hydrochloride gel formulations through mouse skin, Indian J. Pharm. Sci. 68 (2006) 205-211; DOI: 10.4103/0250-474X.25716. (Pubitemid 43900598)
12. R. Kumar, M. B. Patil, S. R. Patil and M. S. Paschapur, Evaluation of Anacardium occidentale gum as gelling agent in aceclofenac gel, Int. J. PharmTech. Res. 1 (2009) 695-704.
13. M. I. Re and B. Biscans, Preparation of microspheres of ketoprofen with acrylic polymers by a quasi-emulsion solvent diffusion method, Powder Technol. 101 (1999) 120-133; DOI: 10.1016/S0032-5910(98)00163-6. (Pubitemid 29087072)
14. J.-H. Lee, T. G. Park and H. K. Choi, Development of oral drug delivery system using floating microspheres, J. Microencapsul. 16 (1999) 715-729; DOI: 10.1080/026520499288663. (Pubitemid 29478951)
15. A. Nokhodchi, M. Jelveghari, M. -R. Siahi and S. Dastmalchi, The effect of formulation type on the release of benzoyl peroxide from microsponges, Iranian J. Pharm. Sci. 1 (2005) 131-142.
16. T. K. Mandal, L. A. Bostanian, R. A. Graves, S. R. Chapman and T. U. Idodo, Porous biodegradable microparticles for delivery of pentamidine, Eur. J. Pharm. Biopharm. 52 (2001) 91-96; DOI: 10.1016/S0939-6411(01)00150-3. (Pubitemid 32594792)
17. M. Kiliçarslan and T. Baykara, The effect of the drug/polymer ratio on the properties of verapamil HCl loaded microspheres, Int. J. Pharm. 252 (2003) 99-109; DOI: 10.1016/S0378-5173(02) 00630-0. (Pubitemid 36126618)
18. P. Piyakulawat, N. Praphairaksit, N. Chantarasiri and N. Muangsin, Preparation and evaluation of chitosan/carrageenan beads for controlled release of sodium diclofenac, AAPS PharmSciTech. 8 (2007) 120-130; DOI: 10.1208/pt0804097. (Pubitemid 351144578)
19. S. Puttipipatkhachorn, T. Pongjanyakul and A. Priprem, Molecular interaction in alginate beads reinforced with sodium starch glycolate or magnesium aluminum silicate, and their physical characteristics, Int. J. Pharm. 293 (2005) 51-62; DOI: 10.1016/j.ijpharm.2004.12.006. (Pubitemid 40381080)