Early fear as a predictor of avoidance in a rat model of post-traumatic stress disorder

Behavioural Brain Research

Volumn 226, Issue 1, 2012, Pages 112-117

  Chen, Xiaoyu ^a   Li, Yonghui ^b   Li, Sa ^a   Kirouac, Gilbert J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b INSTITUTE OF PSYCHOLOGY   (China)

Author keywords

Avoidance; Fear; Footshock; Post traumatic stress disorder; Rat; Stress

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DYSPHORIA; FEAR; FOOTSHOCK; MALE; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PREDICTION; PRIORITY JOURNAL; RAT; VOCALIZATION;

ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; ELECTROSHOCK; FEAR; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; VOCALIZATION, ANIMAL;

EID: 80053343801     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.09.004     Document Type: Article

References (39)

1. Shalev A.Y. Acute stress reactions in adults. Biol Psychiatry 2002, 51:532-543.
2. Harvey A.G., Bryant R.A. Acute stress disorder: a synthesis and critique. Psychol Bull 2002, 128:886-902.
3. Stam R. PTSD and stress sensitisation: a tale of brain and body. Part 1. Human studies. Neurosci Biobehav Rev 2007, 31:530-557.
4. Davidson J.R., Stein D.J., Shalev A.Y., Yehuda R. Posttraumatic stress disorder: acquisition, recognition, course, and treatment. J Neuropsychiatry Clin Neurosci 2004, 16:135-147.
5. Bonne O., Grillon C., Vythilingam M., Neumeister A., Charney D.S. Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy. Neurosci Biobehav Rev 2004, 28:65-94.
6. Kessler R.C., Sonnega A., Bromet E., Hughes M., Nelson C.B. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry 1995, 52:1048-1060.
7. Yehuda R., LeDoux J. Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 2007, 56:19-32.
8. Breslau N., Kessler R.C. The stressor criterion in DSM-IV posttraumatic stress disorder: an empirical investigation. Biol Psychiatry 2001, 50:699-704.
9. Charney D.S., Deutch A.Y., Krystal J.H., Southwick S.M., Davis M. Psychobiologic mechanisms of posttraumatic stress disorder. Arch Gen Psychiatry 1993, 50:295-305.
10. Stam R. PTSD and stress sensitisation: a tale of brain and body. Part 2. Animal models. Neurosci Biobehav Rev 2007, 31:558-584.
11. Siegmund A., Wotjak C.T. A mouse model of posttraumatic stress disorder that distinguishes between conditioned and sensitised fear. J Psychiatr Res 2007, 41:848-860.
12. Mikics E., Baranyi J., Haller J. Rats exposed to traumatic stress bury unfamiliar objects-a novel measure of hyper-vigilance in PTSD models?. Physiol Behav 2008, 94:341-348.
13. Louvart H., Maccari S., Lesage J., Leonhardt M., Dickes-Coopman A., Darnaudery M. Effects of a single footshock followed by situational reminders on HPA axis and behaviour in the aversive context in male and female rats. Psychoneuroendocrinology 2006, 31:92-99.
14. Louvart H., Maccari S., Ducrocq F., Thomas P., Darnaudery M. Long-term behavioural alterations in female rats after a single intense footshock followed by situational reminders. Psychoneuroendocrinology 2005, 30:316-324.
15. van Dijken H.H., Mos J., van der Heyden J.A., Tilders F.J. Characterization of stress-induced long-term behavioural changes in rats: evidence in favor of anxiety. Physiol Behav 1992, 52:945-951.
16. Van Dijken H.H., Tilders F.J., Olivier B., Mos J. Effects of anxiolytic and antidepressant drugs on long-lasting behavioural deficits resulting from one short stress experience in male rats. Psychopharmacology (Berl) 1992, 109:395-402.
17. Mikics E., Toth M., Varju P., Gereben B., Liposits Z., Ashaber M., et al. Lasting changes in social behavior and amygdala function following traumatic experience induced by a single series of foot-shocks. Psychoneuroendocrinology 2008, 33:1198-1210.
18. Bruijnzeel A.W., Stam R., Wiegant V.M. LY354740 attenuates the expression of long-term behavioral sensitization induced by a single session of foot shocks. Eur J Pharmacol 2001, 426:77-80.
19. Bruijnzeel A.W., Stam R., Wiegant V.M. Effect of a benzodiazepine receptor agonist and corticotropin-releasing hormone receptor antagonists on long-term foot-shock-induced increase in defensive withdrawal behavior. Psychopharmacology (Berl) 2001, 158:132-139.
20. Rau V., DeCola J.P., Fanselow M.S. Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. Neurosci Biobehav Rev 2005, 29:1207-1223.
21. Rau V., Fanselow M.S. Exposure to a stressor produces a long lasting enhancement of fear learning in rats. Stress 2009, 12:125-133.
22. Baldi E., Lorenzini C.A., Bucherelli C. Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat. Neurobiol Learn Mem 2004, 81:162-166.
23. Cardena E., Carlson E. Acute stress disorder revisited. Annu Rev Clin Psychol 2011, 7:245-267.
24. Blanchard R.J., Blanchard D.C. Passive and active reactions to fear-eliciting stimuli. J Comp Physiol Psychol 1969, 68:129-135.
25. Haller J., Leveleki C., Baranyi J., Mikics E., Bakos N. Stress, social avoidance and anxiolytics: a potential model of stress-induced anxiety. Behav Pharmacol 2003, 14:439-446.
26. Gutman D.A., Owens M.J., Skelton K.H., Thrivikraman K.V., Nemeroff C.B. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther 2003, 304:874-880.
27. White D.A., Kalinichev M., Holtzman S.G. Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the rat. Brain Res 2007, 1149:141-148.
28. Siegmund A., Wotjak C.T. Hyperarousal does not depend on trauma-related contextual memory in an animal model of Posttraumatic Stress Disorder. Physiol Behav 2007, 90:103-107.
29. Daviu N., Fuentes S., Nadal R., Armario A. A single footshock causes long-lasting hypoactivity in unknown environments that is dependent on the development of contextual fear conditioning. Neurobiol Learn Mem 2010, 94:183-190.
30. Kamprath K., Wotjak C.T. Nonassociative learning processes determine expression and extinction of conditioned fear in mice. Learn Mem 2004, 11:770-786.
31. Pamplona F.A., Henes K., Micale V., Mauch C.P., Takahashi R.N., Wotjak C.T. Prolonged fear incubation leads to generalized avoidance behavior in mice. J Psychiatr Res 2011, 45:354-360.
32. Brudzynski S.M. Pharmacological and behavioral characteristics of 22kHz alarm calls in rats. Neurosci Biobehav Rev 2001, 25:611-617.
33. Litvin Y., Blanchard D.C., Blanchard R.J. Rat 22kHz ultrasonic vocalizations as alarm cries. Behav Brain Res 2007, 182:166-172.
34. Thompson K.E., Vasterling J.J., Benotsch E.G., Brailey K., Constans J., Uddo M., et al. Early symptom predictors of chronic distress in Gulf War veterans. J Nerv Ment Dis 2004, 192:146-152.
35. Weems C.F., Saltzman K.M., Reiss A.L., Carrion V.G. A prospective test of the association between hyperarousal and emotional numbing in youth with a history of traumatic stress. J Clin Child Adolesc Psychol 2003, 32:166-171.
36. Feuer C.A., Nishith P., Resick P. Prediction of numbing and effortful avoidance in female rape survivors with chronic PTSD. J Trauma Stress 2005, 18:165-170.
37. Solomon Z., Horesh D., Ein-Dor T. The longitudinal course of posttraumatic stress disorder symptom clusters among war veterans. J Clin Psychiatry 2009, 70:837-843.
38. Marshall G.N., Schell T.L., Glynn S.M., Shetty V. The role of hyperarousal in the manifestation of posttraumatic psychological distress following injury. J Abnorm Psychol 2006, 115:624-628.
39. Schell T.L., Marshall G.N., Jaycox L.H. All symptoms are not created equal: the prominent role of hyperarousal in the natural course of posttraumatic psychological distress. J Abnorm Psychol 2004, 113:189-197.