Cerebral oxygen transport failure?: Decreasing hemoglobin and hematocrit levels after ischemic stroke predict poor outcome and mortality: Stroke: relevant impact of hemoglobin, hematocrit and transfusion (STRAIGHT) - An observational study

Stroke

Volumn 42, Issue 10, 2011, Pages 2832-2837

  Kellert, Lars ^a   Martin, Evgenia ^a   Sykora, Marek ^b   Bauer, Harald ^c   Gussmann, Philipp ^a   Diedler, Jennifer ^a   Herweh, Christian ^a   Ringleb, Peter A ^a   Hacke, Werner ^a   Steiner, Thorsten ^a   Bösel, Julian ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Faculty of Natural Sciences   (Slovakia)

^c Department of Anesthesiology ^*  (Germany)

Author keywords

acute stroke; hematocrit; hemoglobin; outcome; thrombolysis

Indexed keywords

HEMOGLOBIN;

ACUTE DISEASE; ACUTE ISCHEMIC STROKE; ADULT; AGED; ANEMIA; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CARDIOVASCULAR RISK; CONTROLLED STUDY; DATA BASE; FEMALE; HEMATOCRIT; HOSPITAL ADMISSION; HUMAN; INFORMATION PROCESSING; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; OXYGEN TRANSPORT; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; STROKE PATIENT;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; DATABASES, FACTUAL; FEMALE; FIBRINOLYTIC AGENTS; HEMATOCRIT; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; STROKE; TISSUE PLASMINOGEN ACTIVATOR; TREATMENT OUTCOME;

EID: 80053338173     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.110.606665     Document Type: Article

References (18)

1. Adams HP, Del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A, et al. American Heart Association, American Stroke Association Stroke Council, Clinical Cardiology, Cardiovascular Radiology and Intervention Council, Atherosclerotic Epiphoral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Groups Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists Stroke. 2007;38: 1655-1711.
2. World Health Organization. Iron deficiency anemia assessment, prevention, and control: a guide for programme managers. http://whqlibdocwhoint/hq/2001/ WHO-NHD-013pdf. Accessed October 23, 2010.
3. Zakai NA, Katz R, Hirsch C, Shlipak MG, Chaves PHM, Newman AB, et al. A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study. Arch Intern Med. 2005;165:2214-2220. (Pubitemid 41549915)
4. Penninx BW, Pahor M, Woodman RC, Guralnik JM. Anemia in old age is associated with increased mortality and hospitalization. J Gerontol A Biol Sci Med Sci. 2006;61:474-479. (Pubitemid 43794706)
5. Tanne D, Molshatzki N, Merzeliak O, Tsabari R, Toashi M, Schwannenthal Y. Anemia status, hemoglobin concentration and outcome after acute stroke: a cohort study. BMC Neurol. 2010;10:22.
6. Kramer AH, Zygun DA. Anemia and red blood cell transfusion in neurocritical care. Crit Care. 2009;13:R89. Abstract.
7. Leal-Noval SR, Munoz-Gomez M, Murillo-Cabezas F. Optimal hemoglobin concentration in patients with subarachnoid hemorrhage, acute ischemic stroke and traumatic brain injury. Curr Opin Crit Care. 2008; 14:156-162. (Pubitemid 351498780)
8. Wade JP, Taylor DW, Barnett HJ, Hachinksi VC. Hemoglobin concentration and prognosis in symptomatic obstructive cerebrovascular disease. Stroke. 1987;18:68-71. (Pubitemid 17016688)
9. Bhatia RS, Garg RK, Gaur SPS, Kar AM, Shukla R Agarwal A, et al. Predictive value of routine hematological and biochemical parameters on 30-day fatality in acute stroke. Neurol India. 2004;52:220-223. (Pubitemid 39136957)
10. Grotta J, Ackerman R, Correia J, Fallick G, Chang J. Whole blood viscosity parameters and cerebral blood flow. Stroke. 1982;13:296-301. (Pubitemid 12107349)
11. Allport LE, Parsons MW, Butcher KS, MacGregor L, Desmond PM, Tress BM, et al. Elevated hematocrit is associated with reduced reperfusion and tissue survival in acute stroke. Neurology. 2005;65: 1382-1387. (Pubitemid 41552766)
12. Diamond PT, Gale SD, Evans BA. Relationship of initial hematocrit level to discharge destination and resource utilization after ischemic stroke: a pilot study. Arch Phys Med Rehabil. 2003;84:964-967. (Pubitemid 36835118)
13. Lowe GD, Jaap AJ, Forbes CD. Relation of atrial fibrillation and high haematocrit to mortality in acute stroke. Lancet. 1983;1:784-786. (Pubitemid 13116503)
14. Huang WY, Chen IC, Meng L, Weng WC, Peng TI. The influence of anemia on clinical presentation and outcome of patients with first-ever atherosclerosis-related ischemic stroke. J Clin Neurosci. 2009;16: 645-649.
15. Asplund K. Haemodilution for acute ischaemic stroke. Cochrane Database Syst Rev. 2002;CD000103. Review.
16. Asplund K. Randomized clinical trials of hemodilution in acute ischemic stroke. Acta Neurol Scand Suppl. 1989;127:22-30. (Pubitemid 20049835)
17. Aichner FT, Fazekas F, Brainin M, Polz W, Mamoli B, Zeiler K. Hypervolemic hemodilution in acute ischemic stroke: the Multicenter Austrian Hemodilution Stroke Trial (MAHST). Stroke. 1998;29:743-749. (Pubitemid 28173396)
18. Pearson TC, Wetherley-Mein G. Vascular occlusive episodes and venous haematocrit in primary proliferative polycythaemia. Lancet. 1978;2: 1219-1222. (Pubitemid 9071903)