First-trimester prediction of preeclampsia using metabolomic biomarkers: A discovery phase study

Prenatal Diagnosis

Volumn 31, Issue 10, 2011, Pages 990-994

  Odibo, Anthony O ^a   Goetzinger, Katherine R ^a   Odibo, Linda ^a   Cahill, Alison G ^a   Macones, George A ^a   Nelson, D Michael ^a   Dietzen, Dennis J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Early preeclampsia; First trimester; Maternal serum screening; Metabolomics; Preeclampsia; Screening performance

Indexed keywords

ALANINE; ARGININE; BIOLOGICAL MARKER; CARNITINE DERIVATIVE; GLUTAMIC ACID; HYDROXYHEXANOYLCARNITINE; HYDROXYISOVALERYLCARNITINE; HYDROXYMETHYBUTYRYLCARNITINE; HYDROXYPROLINE; PHENYLALANINE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CASE CONTROL STUDY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DELIVERY; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; METABOLOMICS; PREDICTIVE VALUE; PREECLAMPSIA; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; TANDEM MASS SPECTROMETRY;

ADULT; ALANINE; AREA UNDER CURVE; BIOLOGICAL MARKERS; CARNITINE; CASE-CONTROL STUDIES; FEMALE; GESTATIONAL AGE; GLUTAMIC ACID; HUMANS; METABOLOMICS; PHENYLALANINE; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; REPRODUCIBILITY OF RESULTS;

EID: 80053334601     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2822     Document Type: Article

References (20)

1. Adams SH, Hoppel CL, Lok KH, et al. 2009. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid beta-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr 139: 1073-1081.
2. American College of Obstetricians and Gynecologists. 2002. Diagnosis and Management of Preeclampsia and Eclampsia. The College: Washington, DC; ACOG Practice Bulletin No. 33.
3. Bellamy L, Casas JP, Hingorani AD, Williams DJ. 2007. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ 335: 974.
4. Cuckle HS. 2011. Screening for pre-eclampsia-lessons from aneuploidy screening. Placenta 32(Suppl): S42-S48.
5. Dietzen DJ, Weindel AL, Carayannopoulos MO, et al. 2008. Rapid comprehensive amino acid analysis by liquid chromatography/tandem mass spectrometry: comparison to cation exchange with post-column ninhydrin detection. Rapid Commun Mass Spectrom 22: 3481-3488.
6. Dugoff L, Hobbins JC, Malone FD, et al. 2004. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Gynecol 191(4): 1446-1451.
7. Goetzinger KR, Singla A, Gerkowicz S, Dicke JM, Gray DL, Odibo AO. 2010. Predicting the risk of pre-eclampsia between 11 and 13 weeks' gestation by combining maternal characteristics and serum analytes, PAPP-A and free β-hCG. Prenat Diagn 30(12-13): 1138-1142.
8. Goodacre R, Kell DB. 2003. Evolutionary computation for the interpretation of metabolome data. In Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function. Harrigan GG, Goodacre R (eds). Kluwer Academic Publishers: Boston, MA; 239-256.
9. Kenny L, Dunn W, Ellis D, et al. 2005. Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. Metabolomics 1: 227-234.
10. Kenny LC, Broadhurst D, Brown M, et al. 2008. Detection and identification of novel metabolomic biomarkers in preeclampsia. Reprod Sci 15: 591-597.
11. Kenny LC, Broadhurst DI, Dunn W, et al, 2010. Screening for Pregnancy Endpoints Consortium. 2010. Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension 56(4): 741-749.
12. Levine RJ, Maynard SE, Qian C, et al. 2004. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350: 672-683.
13. Mihalik SJ, Goodpaster BH, Kelley DE, et al. 2010. Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) 18: 1695-1700.
14. Oresic M, Simell S, Sysi-Aho M, et al. 2008. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 205: 2975-2984.
15. Poon LC, Akolekar R, Lachmann R, Beta J, Nicolaides KH. 2010. Hypertensive disorders in pregnancy: screening by biophysical and biochemical markers at 11-13 weeks. Ultrasound Obstet Gynecol 35(6): 662-670.
16. Quehenberger O, Armando AM, Brown AH, et al. 2010. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 51: 3299-3305.
17. Redman CW, Sargent IL. 2005. Latest advances in understanding preeclampsia. Science 308: 1592-1594.
18. Sibai B, Dekker G, Kupferminc M. 2005. Pre-eclampsia. Lancet 365: 785-799.
19. Spencer K, Cowans NJ, Nicolaides KH. 2008. Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia. Prenat Diagn 28: 7-10.
20. Zhong Y, Tuuli M, Odibo AO. 2010. Apr;First-trimester assessment of placenta function and the prediction of preeclampsia and intrauterine growth restriction. Prenat Diagn 30(4): 293-308.