Predicting the risk of pre-eclampsia between 11 and 13 weeks' gestation by combining maternal characteristics and serum analytes, PAPP-A and free β-hCG

Prenatal Diagnosis

Volumn 30, Issue 12-13, 2010, Pages 1138-1142

  Goetzinger, Katherine R ^a   Singla, Ashima ^a   Gerkowicz, Sabrina ^a   Dicke, Jeffrey M ^a   Gray, Diana L ^a   Odibo, Anthony O ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

First trimester screening; Free hCG; PAPP A; Pre eclampsia

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; PREGNANCY ASSOCIATED PLASMA PROTEIN A;

ADULT; AFRICAN AMERICAN; ANEUPLOIDY; ARTICLE; BODY MASS; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; PREDICTION; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SCREENING;

BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; COHORT STUDIES; FEMALE; HUMANS; PRE-ECLAMPSIA; PREDICTIVE VALUE OF TESTS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROGNOSIS; RETROSPECTIVE STUDIES; RISK;

EID: 78649637747     PISSN: 01973851     EISSN: 10970223     Source Type: Journal    
DOI: 10.1002/pd.2627     Document Type: Article

References (20)

1. American College of Obstetricians and Gynecologists. 2001. Chronic Hypertension in Pregnancy, ACOG Practice Bulletin #29. American College of Obstetricians and Gynecologists: Washington, DC; 1-9.
2. American College of Obstetricians and Gynecologists. 2002. Diagnosis and Management of Pre-eclampsia and Eclampsia, ACOG Practice Bulletin #33. American College of Obstetricians and Gynecologists: Washington, DC.
3. Clemmons DR. 1998. Role of insulin-like growth factor binding proteins in controlling IGF actions. Mol Cell Endocrinol 140: 19-24.
4. Confidential Enquiries. 2001. The National Institute for Clinical Excellence, Scottish Executive Health Department; Department of Health, Social Services and Public Safety, Northern Ireland: The Fifth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom 1997-1999. RCOG Press: London; 76-93.
5. Cowans NJ, Spencer K. 2007. First trimester ADAM12 and PAPP-A as markers of intrauterine fetal growth restriction through their roles in the insulin-like growth factor system. Prenat Diagn 27: 264-271.
6. Dugoff L, Hobbins JC, Malone FD, et al. 2004. First-trimester maternal serum PAPP-A and free beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population based screening study (The FASTER Trial). Am J Obstet Gynecol 191: 1446-1451.
7. Irwin JC, Suen LF, Martina NA, et al. 1999. Role of the IGF system in trophoblast invasion and pre-eclampsia. Hum Reprod 14: 90-96.
8. Kniss DA, Shubert PJ, Zimmerman PD, et al. 1994. Insulin-like growth factors: their regulation of glucose and amino acid transport in placental trophoblasts isolated from first trimester chorionic villi. J Reprod Med 39: 249-256.
9. Krantz D, Goetzl L, Simpson JL, et al. 2004. Association of extreme first-trimester free human chorionic gonadotropin-beta, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes. Am J Obstet Gynecol 191: 1452-1458.
10. Ong CYT, Liao AW, Spencer K, et al. 2000. First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications. BJOG 107: 1265-1270.
11. Poon LCY, Akolekar R, Lachmann R, et al. 2010. Hypertensive disorders in pregnancy: screening by biophysical and biochemical markers at 11-13 weeks. Ultrasound Obstet Gynecol 35: 662-670.
12. Smith GCS, Stenhouse EJ, Crossley JA, et al. 2002. Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, pre-eclampsia and stillbirth. J Clin Endocrinol Metab 87: 1762-1767.
13. Spencer K, Cowans NJ, Avgidou K, et al. 2008a. First trimester ultrasound and biochemical markers of aneuploidy and the prediction of small-for-gestational age fetuses. Ultrasound Obstet Gynecol 31: 15-19.
14. Spencer K, Cowans NJ, Molina F, et al. 2008b. First trimester biochemical markers of aneuploidy and the prediction of pre-term or very early pre-term delivery. Ultrasound Obstet Gynecol 31: 147-152.
15. Spencer K, Cowans NJ, Nicolaides KH. 2008c. Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia. Prenat Diagn 28: 7-10.
16. Spencer K, Yu CK, Cowans NJ, et al. 2005. Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler. Prenat Diagn 10: 949-953.
17. Spencer K, Yu CK, Savvidou M, et al. 2006. Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22 + 0 to 24 + 6 weeks' gestation. Ultrasound Obstet Gynecol 27: 658-663.
18. Tul N, Punsenjak S, Osredkar J, et al. 2003. Predicting complications of pregnancy with first-trimester maternal serum free beta-hCG, PAPP-A and inhibin-A. Prenat Diagn 23: 990-996.
19. Yaron Y, Heifetz S, Ochshorn Y, et al. 2002. Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome. Prenat Diagn 22: 778-782.
20. Yu CK, Smith GC, Papageorghiou AT, Cacho AM, Nicolaides KH, Fetal Medicine Foundation Second Trimester Screening Group. 2006. An integrated model for the prediction of pre-eclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk women. Am J Obstet Gynecol 193: 429-436.