Technetium-99 conjugated with methylene diphosphonate ( 99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 8, 2011, Pages 5702-5712

  Lai, Kunbei ^a   Xu, Li ^a   Jin, Chenjin ^a   Wu, Kaili ^a   Tian, Zhen ^a   Huang, Chuangxin ^a   Zhong, Xiaojing ^a   Ye, Haiyun ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; MEDRONATE TECHNETIUM TC 99M; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANTIINFLAMMATORY AGENT; DIAGNOSTIC AGENT; MMP2 PROTEIN, MOUSE; RADIOPHARMACEUTICAL AGENT; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CHOROID; CONTROLLED STUDY; CYTOTOXICITY TEST; DOSE RESPONSE; DOWN REGULATION; ELECTRORETINOGRAPHY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LASER COAGULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SUBRETINAL NEOVASCULARIZATION; ZYMOGRAPHY; ANIMAL; C57BL MOUSE; CELL DIVISION; CELL LINE; CELL MOTION; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; MACACA MULATTA; METABOLISM; PATHOLOGY; PHYSIOLOGY; RETINA; SCINTISCANNING; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DIVISION; CELL LINE; CELL MOVEMENT; CHOROID; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; ENDOTHELIAL CELLS; GENE EXPRESSION; LIGHT COAGULATION; MACACA MULATTA; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; RADIOPHARMACEUTICALS; RETINA; TECHNETIUM TC 99M MEDRONATE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80053327928     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6370     Document Type: Article

References (48)

1. Lee P, Wang CC, Adamis AP. Ocular neovascularization: an epidemiologic review. Surv Ophthalmol. 1998;43:245-269.
2. Green WR. Histopathology of age-related macular degeneration. Mol Vis. 1999;5:27.
3. Lopez PF, Grossniklaus HE, Lambert HM, et al. Pathologic features of surgically excised subretinal neovascular membranes in agerelated macular degeneration. Am J Ophthalmol. 1991;112:647-656.
4. Oh H, Takagi H, Takagi C, et al. The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1999;40:1891-1898.
5. Pollack A, Korte GE, Heriot WJ, Henkind P. Ultrastructure of Bruch's membrane after krypton laser photocoagulation, II: repair of Bruch's membrane and the role of macrophages. Arch Ophthalmol. 1986;104:1377-1382.
6. Kimura H, Spee C, Sakamoto T, et al. Cellular response in subretinal neovascularization induced by bFGF-impregnated microspheres. Invest Ophthalmol Vis Sci. 1999;40:524-528.
7. Sakurai E, Anand A, Ambati BK, van Rooijen N, Ambati J. Macrophage depletion inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:3578-3585.
8. Espinosa-Heidmann DG, Suner IJ, Hernandez EP, Monroy D, Csaky KG, Cousins SW. Macrophage depletion diminishes lesion size and severity in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:3586-3592.
9. Yeh DC, Bula DV, Miller JW, Gragoudas ES, Arroyo JG. Expression of leukocyte adhesion molecules in human subfoveal choroidal neovascular membranes treated with and without photodynamic therapy. Invest Ophthalmol Vis Sci. 2004;45:2368-2373.
10. Sakurai E, Taguchi H, Anand A, et al. Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003;44:2743-2749.
11. Cousins SW, Espinosa-Heidmann DG, Csaky KG. Monocyte activation in patients with age-related macular degeneration: a biomarker of risk for choroidal neovascularization? Arch Ophthalmol. 2004;122:1013-1018.
12. Shi X, Semkova I, Muther PS, Dell S, Kociok N, Joussen AM. Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization. Exp Eye Res. 2006;83:1325-1334.
13. Steen B, Sejersen S, Berglin L, Seregard S, Kvanta A. Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes. Invest Ophthalmol Vis Sci. 1998;39:2194-2200.
14. Jiang N, Liang J, Lu X, Liu S, Zhong F, Wu J. Analysis of the response to treatment of rheumatoid arthritis with 99Tc-MDP [in Chinese]. J Mod Clin Med Bioeng. 2000;6:180-182.
15. Mu R, Chen S, Li Z, Ren L. Therapeutic effect of 99Tc-MDP and its role in proinflammatory cytokines in rheumatoid arthritis [in Chinese]. Chin J Rheumatol. 2004;8:39-41.
16. Sang S, Wu Y, Su C, Zhang W, Dong S. Clinical research of 99Tc-MDP in the treatment of ankylosing spondylitis [in Chinese]. Suzhou Univ J Med Sci. 2006;26:1021-1022.
17. Huang A, Yu L, Shen L. Effect of technetium-99 conjugated with methylene diphosphonate on IgM-RF, IgG-RF and IgA-RF. J Huazhong Univ Sci Tech Med Sci. 2003;23:266-268.
18. Karatay S, Erdem T, Yildirim K, et al. The effect of individualized diet challenges consisting of allergenic foods on TNF-alpha and IL-1beta levels in patients with rheumatoid arthritis. Rheumatology (Oxford). 2004;43:1429-1433.
19. Wang L, Gu Q, Xu Y, et al. Effects of Yunke (technetium-99 conjugated with methylene diphosphonate; (99)Tc-MDP) and/or colloidal chromic phosphate phosphonium-32, alone and in combination, in rats with adjuvant arthritis. Clin Exp Pharmacol Physiol. 2008;35:23-28.
20. Tobe T, Ortega S, Luna JD, et al. Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Am J Pathol. 1998;153:1641-1646.
21. Tobe T, Okamoto N, Vinores MA, et al. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors. Invest Ophthalmol Vis Sci. 1998;39:180-188.
22. Izumi-Nagai K, Nagai N, Ozawa Y, et al. Interleukin-6 receptormediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol. 2007;170:2149-2158.
23. Izumi-Nagai K, Nagai N, Ohgami K, et al. Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin. Invest Ophthalmol Vis Sci. 2008;49:1679-1685.
24. Munaut C, Noel A, Weidle UH, Krell HW, Foidart JM. Modulation of the expression of interstitial and type-IV collagenases in coculture of HT1080 fibrosarcoma cells and fibroblasts. Invasion Metastasis. 1995;15:169-178.
25. Lima e Silva R, Saishin Y, Akiyama H, et al. Suppression and regression of choroidal neovascularization by polyamine analogues. Invest Ophthalmol Vis Sci. 2005;46:3323-3330.
26. He S, Jin ML, Worpel V, Hinton DR. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol. 2003;121:1283-1288.
27. Heussen C, Dowdle EB. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem. 1980;102:196-202.
28. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407:242-248.
29. Cross MJ, Claesson-Welsh L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci. 2001;22:201-207.
30. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389-395.
31. Folkman J, Ingber DE. Angiostatic steroids: method of discovery and mechanism of action. Ann Surg. 1987;206:374-383.
32. Moses MA. The regulation of neovascularization of matrix metalloproteinases and their inhibitors. Stem Cells. 1997;15:180-189.
33. Mignatti P, Rifkin DB. Plasminogen activators and matrix metalloproteinases in angiogenesis. Enzyme Protein. 1996;49:117-137.
34. Berglin L, Sarman S, van der Ploeg I, et al. Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice. Invest Ophthalmol Vis Sci. 2003;44:403-408.
35. Lambert V, Wielockx B, Munaut C, et al. MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB J. 2003;17:2290-2292.
36. Banda MJ, Werb Z. Mouse macrophage elastase: purification and characterization as a metalloproteinase. Biochem J. 1981;193:589-605.
37. Hoffmann S, He S, Ehren M, Ryan SJ, Wiedemann P, Hinton DR. MMP-2 and MMP-9 secretion by RPE is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina. 2006;26:454-461.
38. Grossniklaus HE, Ling JX, Wallace TM, et al. Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis. 2002;8:119-126.
39. Nagai N, Oike Y, Izumi-Nagai K, et al. Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization. Arterioscler Thromb Vasc Biol. 2006;26:2252-2259.
40. Espinosa-Heidmann DG, Reinoso MA, Pina Y, et al. Quantitative enumeration of vascular smooth muscle cells and endothelial cells derived from bone marrow precursors in experimental choroidal neovascularization. Exp Eye Res. 2005;80:369-378.
41. van der Schaft TL, Mooy CM, de Bruijn WC, de Jong PT. Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study. Br J Ophthalmol. 1993;77: 657-661.
42. Sunderkotter C, Steinbrink K, Goebeler M, Bhardwaj R, Sorg C. Macrophages and angiogenesis. J Leukoc Biol. 1994;55:410-422.
43. Csaky KG, Baffi JZ, Byrnes GA, et al. Recruitment of marrowderived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor. Exp Eye Res. 2004;78:1107-1116.
44. Kvanta A, Shen WY, Sarman S, Seregard S, Steen B, Rakoczy E. Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization. Curr Eye Res. 2000;21:684-690.
45. Caicedo A, Espinosa-Heidmann DG, Pina Y, Hernandez EP, Cousins SW. Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. Exp Eye Res. 2005;81:38-47.
46. Elner SG, Elner VM, Pavilack MA, et al. Modulation and function of intercellular adhesion molecule-1 (CD54) on human retinal pigment epithelial cells. Lab Invest. 1992;66:200-211.
47. Mantovani A, Bussolino F, Dejana E. Cytokine regulation of endothelial cell function. FASEB J. 1992;6:2591-2599.
48. Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton DR. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006;171:45-56.