Outdoor, but not indoor, nitrogen dioxide exposure is associated with persistent cough during the first year of life

Science of the Total Environment

Volumn 409, Issue 22, 2011, Pages 4667-4673

  Esplugues, Ana ^a,b   Ballester, Ferran ^a,b,c   Estarlich, Marisa ^a,b   Llop, Sabrina ^a,b   Fuentes Leonarte, Virginia ^a   Mantilla, Enrique ^d   Vioque, Jesús ^a,e   Iñiguez, Carmen ^a,b  

^a CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^b Center for Public Health Research CSISP   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d FUNDACIÓN CENTRO DE ESTUDIOS AMBIENTALES DEL MEDITERRÁNEO CEAM   (Spain)

^e MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

Air pollution; Cough; Infant; Nitrogen dioxide; Respiratory Infection

Indexed keywords

AMBIENT POLLUTION; BRONCHIOLITIS; CONFIDENCE INTERVAL; COUGH; CUMULATIVE INCIDENCE; EMPIRICAL MEASUREMENT; FIRST YEAR; IMMUNE SYSTEMS; INFANT; LAND USE REGRESSION; MULTIPLE LOGISTIC REGRESSION; NITROGEN DIOXIDE; NITROGEN DIOXIDES; ODDS RATIOS; PASSIVE SAMPLERS; POSTNATAL EXPOSURE; PRENATAL EXPOSURE; RESPIRATORY DISEASE; RESPIRATORY INFECTION; RESPIRATORY TRACT INFECTIONS; SAMPLING PERIOD; SAMPLING SITE; STUDY AREAS; TRAFFIC-RELATED AIR POLLUTION; VALENCIA;

AIR POLLUTION; GEOGRAPHIC INFORMATION SYSTEMS; NITROGEN; SURVEYS;

NITROGEN OXIDES;

NITROGEN DIOXIDE;

ATMOSPHERIC POLLUTION; CHILD HEALTH; GIS; HEALTH IMPACT; HEALTH RISK; MULTIPLE REGRESSION; NITROGEN DIOXIDE; POLLUTION EXPOSURE; RESPIRATORY DISEASE; RISK ASSESSMENT;

AIR POLLUTION; ARTICLE; BRONCHIOLITIS; BRONCHITIS; CHILD; CHRONIC COUGH; CONTROLLED STUDY; COUGHING; FEMALE; GEOGRAPHIC INFORMATION SYSTEM; HUMAN; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PATHOPHYSIOLOGY; PERINATAL DRUG EXPOSURE; PNEUMONIA; POPULATION RESEARCH; PRENATAL DRUG EXPOSURE; PRESCHOOL CHILD; PRIORITY JOURNAL; QUESTIONNAIRE; SPAIN; WHEEZING;

COUGH; ENVIRONMENTAL EXPOSURE; FEMALE; GEOGRAPHIC INFORMATION SYSTEMS; HUMANS; INCIDENCE; INFANT; LOGISTIC MODELS; MODELS, THEORETICAL; NITROGEN DIOXIDE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; QUESTIONNAIRES; RESPIRATORY SOUNDS; RESPIRATORY TRACT INFECTIONS; SPAIN; VEHICLE EMISSIONS;

COMUNIDAD VALENCIA; SPAIN;

EID: 80053322943     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2011.08.007     Document Type: Article

References (53)

1. Aguilera I., Sunyer J., Fernández-Patier R., Hoek G., Aguirre-Alfaro A., Meliefste K., et al. Estimation of outdoor NO(x), NO(2), and BTEX exposure in a cohort of pregnant women using land use regression modeling. Environ Sci Technol 2008, 42:815-821.
2. Basu R., Samet J.M. A review of the epidemiological evidence on health effects of nitrogen dioxide exposure from gas stoves. J Environ Med 1999, 1:173-187.
3. Belanger K., Beckett W., Triche E., Bracken M.B., Holford T., Ren P., et al. Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. Am J Epidemiol 2003, 158:195-202.
4. Brauer M., Hoek G., Van Vliet P., Meliefste K., Fischer P.H., Wijga A., et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med 2002, 166(8):1092-1098. Oct 15.
5. Brauer M., Gehring U., Brunekreef B., de Jongste J., Gerritsen J., Rovers M., et al. Traffic-related air pollution and otitis media. Environ Health Perspect 2006, 114(9):1414-1418.
6. Brauer M., Hoek G., Smit H.A., de Jongste J.C., Gerritsen J., Postma D.S., et al. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J 2007, 29(5):879-888.
7. Ciuk J., Volkmer R.E., Edwards J.W. Domestic nitrogen oxide exposure, urinary nitrate, and asthma prevalence in preschool children. Arch Environ Health 2001, 56:433-438.
8. Cyrys J., Heinrich J., Richter K., Wolke G., Wichmann H.E. Sources and concentrations of indoor nitrogen dioxide in Hamburg (west Germany) and Erfurt (east Germany). Sci Total Environ 2000, 250(1-3):51-62.
9. Domingo-Salvany A., Regidor E., Alonso J., Alvarez-Dardet C. Proposal for a social class measure. Working Group of the Spanish Society of Epidemiology and the Spanish Society of Family and Community Medicine. Aten Primaria 2000, 25:350-363.
10. 2, as a marker of air pollution, and recurrent wheezing in children: a nested case-control study within the BAMSE birth cohort. Occup Environ Med 2003, 60:876-881.
11. 2 in a cohort of 1-year-old children in Valencia, Spain. Indoor Air 2010, 20:213-223.
12. Farrow A., Greenwood R., Preece S., Golding J. Nitrogen dioxide, the oxides of nitrogen, and infants' health symptoms. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Arch Environ Health 1997, 52:189-194.
13. Franck U., Herbarth O., Röder S., Schlink U., Borte M., Diez U., et al. Respiratory effects of indoor particles in young children are size dependent. Sci. Total Environ. 2011, 409(9):1621-1631.
14. Fuentes-Leonarte V., Tenias J.M., Ballester F. Environmental factors affecting children's respiratory health in the first years of life: a review of the scientific literature. Eur J Pediatr 2008, 167(10):1103-1109.
15. Fuentes-Leonarte V., Tenias J.M., Ballester F. Levels of pollutants in indoor air and respiratory health in preschool children: a systematic review. Pediatr Pulmonol 2009, 44:231-243.
16. 2 in homes of Ashford, UK and Barcelona and Menorca, Spain. Indoor Air 2004, 14(4):298-304.
17. Gauderman W.J., Avol E., Lurmann F., Kuenzli N., Gilliland F., Peters J., et al. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 2005, 16(6):737-743.
18. Gauvin S., Le Moullec Y., Bremont F., Momas I., Balducci F., Ciognard F., et al. Relationships between nitrogen dioxide personal exposure and ambient air monitoring measurements among children in three French metropolitan areas: VESTA study. Arch Environ Health 2001, 56(4):336-341.
19. Gehring U., Cyrys J., Sedlmeir G., Brunekreef B., Bellander T., Fischer P., Bauer C.P., Reinhardt D., Wichmann H.E., Heinrich J. Traffic-related air pollution and respiratory health during the first 2yrs of life. Eur Respir J 2002, 19:690-698.
20. Gehring U., Wijga A.H., Brauer M., Fischer P., de Jongste J.C., Kerkhof M., et al. Traffic-related air pollution and the development of asthma and allergies during the first 8years of life. Am J Respir Crit Care Med 2010, 181(6):596-603.
21. Iñiguez C., Ballester F., Estarlich M., Llop S., Fernandez-Patier R., Guirre-Alfaro A., Esplugues A. Estimation of personal NO2 exposure in a cohort of pregnant women. Sci Total Environ 2009, 407:6093-6099.
22. Jedrychowski W., Galas A., Pac A., Flak E., Camman D., Rauh V., et al. Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life. Eur J Epidemiol 2005, 20:775-782.
23. Jedrychowski W., Perera F.P., Maugeri U., Mrozek-Budzyn D., Mroz E., Flak E., et al. Early wheezing phenotypes and severity of respiratory illness in very early childhood: study on intrauterine exposure to fine particle matter. Environ Int 2009, 35:877-884.
24. Jedrychowski W., Maugeri U., Perera F.P., Mroz E., Klimaszewska-Rembiasz M., Flak E., et al. Early wheeze as reported by mothers and lung function in 4-year-olds. Prospective cohort study in Krakow. Pediatr Pulmonol 2010, 45(9):919-926. Sep.
25. Kraft M., Eikmann T., Kappos A., Kunzli N., Rapp R., Schneider K., Seitz H., Voss J.U., Wichmann H.E. The German view: effects of nitrogen dioxide on human health-derivation of health-related short-term and long-term values. Int J Hyg Environ Health 2005, 208:305-318.
26. Kusel M.M., de Klerk N.H., Kebadze T., Vohma V., Holt P.G., Johnston S.L., et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007, 119:1105-1110.
27. Latzin P., Roosli M., Huss A., Kuehni C.E., Frey U. Air pollution during pregnancy and lung function in newborns: a birth cohort study. Eur Respir J 2009, 33(3):594-603. Mar.
28. Linaker C.H., Chauhan A.J., Inskip H., Frew A.J., Sillence A., Coggon D., et al. Distribution and determinants of personal exposure to nitrogen dioxide in school children. Occup Environ Med 1996, 53(3):200-203.
29. Ma L., Shima M., Yoda Y., Yamamoto H., Nakai S., Tamura K., et al. Effects of airborne particulate matter on respiratory morbidity in asthmatic children. J Epidemiol 2008, 18:97-110.
30. Magnus P., Nafstad P., Oie L., Carlsen K.C.L., Becher G., Kongerud J., Samuelsen S.O., Botten G., Bakketeig L.S. Exposure to nitrogen dioxide and the occurrence of bronchial obstruction in children below 2years. Int J Epidemiol 1998, 27:995-999.
31. McConnell R., Islam T., Shankardass K., Jerrett M., Lurmann F., Gilliland F., et al. Childhood incident asthma and traffic-related air pollution at home and school. Environ Health Perspect 2010, 118:1021-1026.
32. McCormack M.C., Breysse P.N., Matsui E.C., Hansel N.N., Williams D., Curtin-Brosnan J., et al. In-home particle concentrations and childhood asthma morbidity. Environ Health Perspect 2009, 117:294-298.
33. Miyake Y., Tanaka K., Fujiwara H., Mitani Y., Ikemi H., Sasaki S., Ohya Y., Hirota Y. Residential proximity to main roads during pregnancy and the risk of allergic disorders in Japanese infants: the Osaka Maternal and Child Health Study. Pediatr Allergy Immunol 2010, 21:22-28.
34. Mortimer K., Neugebauer R., Lurmann F., Alcorn S., Balmes J., Tager I. Air Pollution and Pulmonary Function in Asthmatic Children: Effects of Prenatal and Lifetime Exposures. Epidemiology 2008, 19(4):550-557.
35. Mortimer K., Neugebauer R., Lurmann F., Alcorn S., Balmes J., Tager I. Early-lifetime exposure to air pollution and allergic sensitization in children with asthma. J Asthma 2008, 45(10):874-881. Dic.
36. Pénard-Morand C., Raherison C., Charpin D., Kopferschmitt C., Lavaud F., Caillaud D., et al. Long-term exposure to close-proximity air pollution and asthma and allergies in urban children. Eur Respir J 2010, 36(1):33-40. Jul.
37. Polk S., Sunyer J., Munoz-Ortiz L., Barnes M., Torrent M., Figueroa C., et al. A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezing. Am J Respir Crit Care Med 2004, 170:273-278.
38. R Development Core Team R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria 2010, URL. http://www.R-project.org.
39. Ramon R., Ballester F., Rebagliato M., Ribas N., Torrent M., Fernandez M., et al. [The environment and childhood research network ("INMA" network): study protocol] La Red de Investigacion "Infancia y Medio Ambiente" (Red INMA): protocolo de estudio. Rev Esp Salud Publica 2005, 79:203-220.
40. Regidor E., Gutiérrez-Fisac J.L., Alfaro M. Health Indicators 2009. Trends in health status indicators in Spain and their magnitude in the context of the European Union. Madrid: Ministry of Health and Social Policy [Consulted on 28-06-2011], Available at, 2011. http://www.msps.es/estadEstudios/estadisticas/inforRecopilaciones/indicadoresSalud.htm.
41. Ribas-Fito N., Ramon R., Ballester F., Grimalt J., Marco A., Olea N., et al. Child health and the environment: the INMA Spanish Study. Paediatr Perinat Epidemiol 2006, 20:403-410.
42. Rotko T., Kousa A., Alm S., Jantunen M. Exposures to nitrogen dioxide in EXPOLIS-Helsinki: microenvironment, behavioral and sociodemographic factors. J Expo Anal Environ Epidemiol 2001, 11(3):216-223. May.
43. Sahsuvaroglu T., Su J.G., Brook J., Burnett R., Loeb M., Jerrett M. Predicting personal nitrogen dioxide exposure in an elderly population: integrating residential indoor and outdoor measurements, fixed-site ambient pollution concentrations, modeled pollutant levels, and time-activity patterns. J Toxicol Environ Health A 2009, 72:1520-1533.
44. Schwartz J. Air pollution and children's health. Pediatrics 2004, 113:1037-1043.
45. Slama R., Morgenstern V., Cyrys J., Zutavern A., Herbarth O., Wichmann H.E., et al. Traffic related atmospheric pollutants levels during pregnancy and offspring's term birth weight: a study relying on a land-use regression exposure model. Environ Health Perspect 2007, 115(9):1283-1292.
46. Stata Corp Stata Statistical Software: Release 9. College Station, TX: StataCorp LP 2005.
47. Stick S. Pediatric origins of adult lung disease. The contribution of airway development to paediatric and adult lung disease. Thorax 2000, 55:587-594.
48. Sunyer J., Puig C., Torrent M., Garcia-Algar O., Calico I., Munoz-Ortiz L., Barnes M., Cullinan P. Nitrogen dioxide is not associated with respiratory infection during the first year of life. Int J Epidemiol 2004, 33:116-120.
49. Sunyer J., Garcia-Esteban R., Alvarez M., Guxens M., Goni F., Basterrechea M., et al. DDE in mothers' blood during pregnancy and lower respiratory tract infections in their infants. Epidemiology 2010, 21(5):729-735. Sep.
50. Turnovska T.H., Marinov B.I. The influence of air pollution during intrauterine development and early childhood on respiratory functions at later age. Int J Hyg Environ Health 2009, 212:519-532.
51. 2 and nitrous acid and respiratory symptoms in the first year of life. Epidemiology 2004, 15:471-478.
52. von Linstow M., Holst K.K., Larsen K., Koch A., Andersen P.K., Høgh B. Acute respiratory symptoms and general illness during the first year of life: a population-based birth cohort study. Pediatr Pulmonol 2008, 43:584-593.
53. Yu C.H., Morandi M.T., Weisel C.P. Passive dosimeters for nitrogen dioxide in personal/indoor air sampling: a review. J Expo Sci Environ Epidemiol 2008, 18:441-451.