A mouse model of in Utero transplantation

Journal of Visualized Experiments

Volumn , Issue 47, 2010, Pages

  Nijagal, Amar ^a   Le, Tom ^a   Wegorzewska, Marta ^a   MacKenzie, Tippi C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Development; In utero; Issue 47; Medicine; Stem cells; Transplantation

Indexed keywords

EID: 80053315386     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2303     Document Type: Article

References (19)

1. Flake, A. W. et al. Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow. N Engl J Med 335, 1806-1810 (1996).
2. Wengler, G. S. et al. In-utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDXI). Lancet 348, 1484-1487 (1996).
3. Flake, A. W. & Zanjani, E. D. in utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers. Blood 94, 2179-2191 (1999).
4. Merianos, D. J. et al. Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice. J Clin Invest 119, 2590-2600 (2009).
5. Peranteau, W. H., Endo, M., Adibe, O. O. & Flake, A. W. Evidence for an immune barrier after in utero hematopoietic-cell transplantation. Blood 109, 1331-1333 (2007).
6. Kim, H. B., Shaaban, A. F., Yang, E. Y., Liechty, K. W. & Flake, A. W. Microchimerism and tolerance after in utero bone marrow transplantation in mice. J Surg Res 77, 1-5 (1998).
7. Durkin, E. T., Jones, K. A., Rajesh, D. & Shaaban, A. F. Early chimerism threshold predicts sustained engraftment and NK-cell tolerance in prenatal allogeneic chimeras. Blood 112, 5245-5253 (2008).
8. Mackenzie, T. C., Shaaban, A. F., Radu, A. & Flake, A. W. Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice. J Pediatr Surg 37, 1058-1064 (2002).
9. Hayashi, S. et al. Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy. Exp Hematol 31, 176-184 (2003).
10. Bouchard, S. et al. Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice. J Gene Med 5, 941-950 (2003).
11. Meza, N. W. et al. Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. Mol Ther 17, 2000-2009 (2009).
12. MacKenzie, T. C. et al. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Mol Ther 6, 349-358 (2002).
13. MacKenzie, T. C. et al. Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors. J Gene Med 7, 50-58 (2005).
14. Sabatino, D. E. et al. Persistent expression of hF. IX After tolerance induction by in utero or neonatal administration of AAV-1-F. IX in hemophilia B mice. Mol Ther 15, 1677-1685 (2007).
15. Mellor, A. L. & Munn, D. H. Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol 18, 367-391 (2000).
16. Billingham, R. E., Brent, L. & Medawar, P. B. Actively acquired tolerance of foreign cells. Nature 172, 603-606 (1953).
17. Endo, M. et al. Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector. Mol Ther 15, 579-587 (2007).
18. Waddington, S. N. et al. Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice. Gene Ther 10, 1234-1240 (2003).
19. Schachtner, S., Buck, C., Bergelson, J. & Baldwin, H. Temporally regulated expression patterns following in utero adenovirus-mediated gene transfer. Gene Ther 6, 1249-1257 (1999).