Cytotoxic and anti-infective phenolic compounds isolated from Mikania decora and Cremastosperma microcarpum

Planta Medica

Volumn 77, Issue 14, 2011, Pages 1597-1599

  Aponte, José C ^a,b   Jin, Zhuang ^a   Vaisberg, Abraham J ^c   Castillo, Denis ^c   Málaga, Edith ^c   Lewis, Walter H ^d   Sauvain, Michel ^e,f   Gilman, Robert H ^g   Hammond, Gerald B ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b BROWN UNIVERSITY   (United States)

^c UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^d WASHINGTON UNIVERSITY   (United States)

^e UNIVERSITÉ DE TOULOUSE   (France)

^f UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^g JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

anticancer; antileishmania; Compositae; Cremastosperma microcarpum Annonaceae; Mikania decora; trypanoside

Indexed keywords

10 ACETOXY 8,9 DEHYDRO 6 METHOXYTHYMOL BUTYRATE; 10 ACETOXY 8,9 EPOXY 6 METHOXYTHYMOL ISOBUTYRATE; ACETYLSCHIZOGINOL; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; CREMASTOSPERMA MICROCARPUM; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; EMBRYO; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEISHMANIA; LUNG CANCER; MALE; MELANOMA; MIKANIA; MIKANIA DECORA; MOUSE; MYELOID LEUKEMIA; NONHUMAN; PROSTATE CARCINOMA; TRYPANOSOMA CRUZI;

ANIMALS; ANNONACEAE; ANTI-INFECTIVE AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; FEMALE; HUMANS; LEISHMANIA; LIGNANS; MACROPHAGES; MALE; MICE; MIKANIA; PARASITIC SENSITIVITY TESTS; PERU; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PLANT STEMS; THYMOL; TREES; TRYPANOSOMA CRUZI;

ANNONACEAE; ASTERACEAE; CREMASTOSPERMA MICROCARPUM; LEISHMANIA AMAZONENSIS; MIKANIA; TRYPANOSOMA CRUZI;

EID: 80053310631     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1270960     Document Type: Article

References (24)

1. Altmann K H., Gertsch J. Anticancer drugs from nature-natural products as a unique source of new microtubule-stabilizing agents. Nat Prod Rep 2007 24 327-357 (Pubitemid 46504987)
2. Koehn F E., Carter G T. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 2005 4 206-220 (Pubitemid 40372555)
3. Paterson I, Anderson E A. The renaissance of natural products as drug candidates. Science 2005 310 451-453 (Pubitemid 41507948)
4. Cordell G A., Colvard M D. Some thoughts on the future of ethnopharmacology. J Ethnopharmacol 2005 100 5-14 (Pubitemid 41078736)
5. Lewis W H., Lamas G, Vaisberg A, Corley D G., Sarasara C, Albán J, Apanú R, Castro R, Crandall C, Elvin-Lewis M, Fritz W, Hammond G, Klueh P, Millán B, Okunade A, Pacheco V, Tovar O, Yarupaitán G. Peruvian medicinal plant sources of new pharmaceuticals (International Cooperative Biodiversity Group-Peru). Pharm Biol 1999 37 69-83 (Pubitemid 129725346)
6. Aponte J C., Vaisberg A J., Rojas R, Sauvain M, Lewis W H., Lamas G, Sarasara C, Gilman R H., Hammond G B. A multipronged approach to the study of Peruvian ethnomedicinal plants: a legacy of the ICBG-Peru Project. J Nat Prod 2009 72 524-526
7. Aponte J C., Yang H, Vaisberg A J., Castillo D, Málaga E, Verástegui M, Casson L K., Stivers N, Bates P J., Rojas R, Fernandez I, Lewis W H., Sarasara C, Sauvain M, Gilman R H., Hammond G B. Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae). Planta Med 2010 76 705-707
8. Aponte J C., Vaisberg A J., Rojas R, Caviedes L, Lewis W L., Lamas G, Sarasara C, Gilman R H., Hammond G B. Isolation of cytotoxic metabolites from targeted Peruvian Amazonian medicinal plants. J Nat Prod 2008 71 102-105 (Pubitemid 351236405)
9. Aponte J C., Estevez Y, Gilman R H., Lewis W H., Rojas R, Sauvain M, Vaisberg A J., Hammond G B. Anti-infective and cytotoxic compounds present in Blepharodon nitidum. Planta Med 2008 74 407-410 (Pubitemid 351578798)
10. Catalán C A. N., Cuenca M R., Hernández L R., Joseph-Nathan P. cis,cis -Germacranolides and melampolides from Mikania thapsoides. J Nat Prod 2003 66 949-953 (Pubitemid 36909841)
11. Krautmann M, de Riscala E C., Burgueno-Tapia E, Mora-Perez Catalán C A. N., Joseph-Nathan P. C-15-Functionalized eudesmanolides from Mikania campanulata. J Nat Prod 2007 70 1173-1179 (Pubitemid 47279911)
12. Cava M P., Wakisaka K, Noguchi I, Edie D L. Phlebicine, a new biphenylbisbenzylisoquinoline alkaloid from Cremastosperma polyphlebum. J Org Chem 1974 39 3588-3591
13. Mihashi S, Yanagisawa I, Tanaka O, Shibata S. Further study on the diterpenes of Aralia spp. Tetrahedron Lett 1969 21 1683-1686
14. Matsuo A, Uto S, Nakayama M, Hayashi S, Yamasaki K, Kasai R, Tanaka O. ()-Thermarol, a new ent -pimarane-class diterpene diol from Jungermannia thermarum (Liverwort). Tetrahedron Lett 1976 28 2451-2454
15. González A G., Bermejo Barrera J, Estévez Rosas F, Yanes Hernandez A C., Espiñeira J, Josep-Nathan P. Thymol derivatives from Schizogyne glaberrima. Phytochemistry 1986 25 2889-2891
16. Bohlmann F, Jakupovic J, Lonitz M. Über Inhaltsstoffe der Eupatorium-Gruppe. Chem Ber 1977 110 301-314
17. González A G., Bermejo J, Estévez F, Yanes A C., Joseph-Nathan P. Derivados fenolicos del genero Schizogyne. Rev Latinoam Quím 1986 17 54-56
18. González A G., Bermejo Barrera J, Castaneda Acosta J, Estévez Rosas F. Anti-inflammatory activity of Schizogyne species. Fitoterapia 1988 59 476-478 (Pubitemid 19071520)
19. Aiba C J., Correa R G. C., Gottlieb O R. Natural occurrence of Erdtman's dehydrodiisoeugenol. Phytochemistry 1973 12 1163-1164
20. Enriquez R G., Chaves M A. Phytochemical investigations of plant of the genus Aristolochia, 1. Isolation and NMR spectral characterization of eupomatenoid derivatives. J Nat Prod 1984 47 896-899 (Pubitemid 15222641)
21. Bortolomeazzi R, Verardo G, Liessi A, Callea A. Formation of dehydrodiisoeugenol and dehydrodieugenol from the reaction of isoeugenol and eugenol with DPPH radical and their role in the radical scavenging activity. Food Chem 2010 118 256-265
22. Atsumi T, Fujisawa S, Satoh K, Sakagami H, Iwakura I, Uehai T, Sugita Y, Yokoe I. Cytotoxicity and radical intensity of eugenol, isoeugenol or related dimers. Anticancer Res 2000 20 2519-2524 (Pubitemid 30614462)
23. Le Quesne P W., Larrahondo J E., Raffauf R F. Antitumor plants. X. Constituents of Nectandra rigida. J Nat Prod 1980 43 353-359 (Pubitemid 11232917)
24. Meyer I, Koch O, Krutmann J. Use of dihydrodehydrodiisoeugenol as skin care preparations. PCT Int Appl 2010; WO 2010070152 A2 20100624.