The optimal dose of prophylactic intravenous naloxone in ameliorating opioid-induced side effects in children receiving intravenous patient-controlled analgesia morphine for moderate to severe pain: A dose finding study

Anesthesia and Analgesia

Volumn 113, Issue 4, 2011, Pages 834-842

  Monitto, Constance L ^a   Kost Byerly, Sabine ^a   White, Elizabeth ^a   Lee, Carlton K K ^a   Rudek, Michelle A ^a   Thompson, Carol ^b   Yaster, Myron ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; NALOXONE;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; CHILD; CONTINUOUS INFUSION; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG EFFICACY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; OUTCOME ASSESSMENT; PATIENT CONTROLLED ANALGESIA; POSTOPERATIVE PAIN; PRESCHOOL CHILD; PRIORITY JOURNAL; PRURITUS; QUANTITATIVE ANALYSIS; SCHOOL CHILD; TANDEM MASS SPECTROMETRY; TREATMENT FAILURE; VOMITING;

EID: 80053310593     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31822c9a44     Document Type: Article

References (33)

1. Gan TJ, Ginsberg B, Glass PS, Fortney J, Jhaveri R, Perno R. Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997; 87:1075-81 (Pubitemid 27469306)
2. Maxwell LG, Kaufmann SC, Bitzer S, Jackson EV Jr, McGready J, Kost-Byerly S, Kozlowski L, Rothman SK, Yaster M. The effects of a small-dose naloxone infusion on opioid-induced side effects and analgesia in children and adolescents treated with intravenous patient-controlled analgesia: a double-blind, prospective, randomized, controlled study. Anesth Analg 2005;100:953-8 (Pubitemid 40409506)
3. Wong DL, Baker C. Pain in children: comparison of assessment scales. Pediatr Nurs 1988;14:9-17
4. McCaffery M, Beebe A. Pain: Clinical Manual for Nursing Practice. Baltimore: Mosby, 1993
5. Shah VP, Midha KK, Dighe S, McGilveray IJ, Skelly JP, Yacobi A, Layloff T, Viswanathan CT, Cook CE, McDowall RD. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies: conference report. Eur J Drug Metab Pharmacokinet 1991;16:249-55
6. Crain SM, Shen KF. Antagonists of excitatory opioid receptor functions enhance morphinés analgesic potency and attenuate opioid tolerance/dependence. Pain 2000;84:121-31 (Pubitemid 30074213)
7. Wang HY, Friedman E, Olmstead MC, Burns LH. Ultra-lowdose naloxone suppresses opioid tolerance, dependence and associated changes in mu opioid receptor-G protein coupling and G signaling. Neuroscience 2005;135:247-61 (Pubitemid 41219753)
8. Cepeda MS, Africano JM, Manrique AM, Fragoso W, Carr DB. The combination of low dose of naloxone and morphine in PCA does not decrease opioid requirements in the postoperative period. Pain 2002;96:73-9 (Pubitemid 34270630)
9. Cepeda MS, Alvarez H, Morales O, Carr DB. Addition of ultralow dose naloxone to postoperative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain 2004;107:41-6 (Pubitemid 38058697)
10. Sartain JB, Barry JJ, Richardson CA, Branagan HC. Effect of combining naloxone and morphine for intravenous patientcontrolled analgesia. Anesthesiology 2003;99:148-51 (Pubitemid 36799045)
11. Joshi GP, Duffy L, Chehade J, Wesevich J, Gajraj N, Johnson ER. Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. Anesthesiology 1999;90:1007-11 (Pubitemid 29159757)
12. Yeh YC, Lin TF, Wang CH, Wang YP, Lin CJ, Sun WZ. Effect of combining ultralow-dose naloxone with morphine in intravenous patient-controlled analgesia: the cut-off ratio of naloxone to morphine for antiemesis after gynecologic surgery. J Formos Med Assoc 2008;107:478-84
13. Dal D, Kanbak M, Caglar M, Aypar U. A background infusion of morphine does not enhance postoperative analgesia after cardiac surgery. Can J Anaesth 2003;50:476-9 (Pubitemid 36833604)
14. Voepel-Lewis T, Marinkovic A, Kostrzewa A, Tait AR, Malviya S. The prevalence of and risk factors for adverse events in children receiving patient-controlled analgesia by proxy or patient-controlled analgesia after surgery. Anesth Analg 2008;107:70-5
15. Doyle E, Harper I, Morton NS. Patient-controlled analgesia with low dose background infusions after lower abdominal surgery in children. Br J Anaesth 1993;71:818-22 (Pubitemid 23356625)
16. Fleming BM, Coombs DW. A survey of complications documented in a quality-control analysis of patient controlled analgesia in the postoperative patient. J Pain Symptom Manage 1992;7:463-9 (Pubitemid 23009074)
17. Nelson KL, Yaster M, Kost-Byerly S, Monitto CL. A national survey of American pediatric anesthesiologists: patientcontrolled analgesia and other intravenous opioid therapies in pediatric acute pain management. Anesth Analg 2010;110: 754-60
18. Koch J, Manworren R, Clark L, Quinn CT, Buchanan GR, Rogers ZR. Pilot study of continuous co-infusion of morphine and naloxone in children with sickle cell pain crisis. Am J Hematol 2008;83:728-31
19. Porreca F, Ossipov MH. Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options. Pain Med 2009;10:654-62
20. Kraft MD. Methylnaltrexone, a new peripherally acting muopioid receptor antagonist being evaluated for the treatment of postoperative ileus. Expert Opin Investig Drugs 2008;17: 1365-77
21. Lynn AM, Nespeca MK, Bratton SL, Shen DD. Ventilatory effects of morphine infusions in cyanotic versus acyanotic infants after thoracotomy. Paediatr Anaesth 2003;13: 12-7 (Pubitemid 36114994)
22. Bouwmeester NJ, van den Anker JN, Hop WCJ, Anand KJS, Tibboel D. Age-and therapy-related effects on morphine requirements and plasma concentrations of morphine and its metabolites in postoperative infants. Br J Anaesth 2003; 90:642-52 (Pubitemid 36592339)
23. Dahlström B, Bolme P, Feychting H, Noack G, Paalzow L. Morphine kinetics in children. Clin Pharmacol Ther 1979; 26:354-65 (Pubitemid 10194677)
24. Darnell CM, Thompson J, Stromberg D, Roy L, Sheeran P. Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. Pediatrics 2008;121:e1363-71
25. Wiesenfeld-Hallin Z. Sex differences in pain perception. Gend Med 2005;2:137-45 (Pubitemid 41700276)
26. Dahan A, Kest B, Waxman AR, Sarton E. Sex-specific responses to opiates: animal and human studies. Anesthesiology 2008;107:83-93
27. Riley JL III, Robinson ME, Wise EA, Price DD. A meta-analytic review of pain perception across the menstrual cycle. Pain 1999;81:225-35 (Pubitemid 29257893)
28. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, Levine JD. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med 1996;2:1248-50 (Pubitemid 26375411)
29. Chia YY, Chow LH, Hung CC, Liu K, Ger LP, Wang PN. Gender and pain upon movement are associated with the requirements for postoperative patient-controlled iv analgesia: a prospective survey of 2,298 Chinese patients. Can J Anaesth 2002;49:249-55 (Pubitemid 34460770)
30. Cepeda MS, Carr DB. Women experience more pain and require more morphine than men to achieve a similar degree of analgesia. Anesth Analg 2003;97:1464-8 (Pubitemid 37310148)
31. Aubrun F, Salvi N, Coriat P, Riou B. Sex-and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology 2005;103:156-60 (Pubitemid 40943148)
32. Netzer P, Sendensky A, Wissmeyer MP, Baumeler S, Batista C, Scheurer U, Krause T, Reber P, Brenneisen R. The effect of naloxone-3-glucuronide on colonic transit time in healthy men after acute morphine administration: a placebo-controlled double-blinded crossover preclinical volunteer study. Aliment Pharmacol Ther 2008;28:1334-41
33. Reber P, Brenneisen R, Flogerzi B, Batista C, Netzer P, Scheurer U. Effect of naloxone-3-glucuronide and N-methylnaloxone on the motility of the isolated rat colon after morphine. Dig Dis Sci 2007;52:502-7 (Pubitemid 46202827)