Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 5, 2011, Pages 855-861

  Karbach, Susanne ^a   Simon, Alexandra ^a   Slenzka, Anita ^a   Jaenecke, Isabel ^a   Habermeier, Alice ^a   Martiné, Ursula ^a   Förstermann, Ulrich ^a   Closs, Ellen I ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Citrulline to arginine recycling; Endothelial dysfunction; Endothelial NO synthase (eNOS); Lysosomal and proteasomal protein degradation; Peptide histidine transporter (PHT1)

Indexed keywords

AMINO ACID TRANSPORTER; ARGININE; CELL PROTEIN; CITRULLINE; DIPEPTIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTAMINE; HISTIDINE; LYSINE; LYSOSOME PROTEIN; PEPTIDE HISTIDINE TRANSPORTER 1; PROTEASOME; UNCLASSIFIED DRUG;

ARTICLE; BLADDER CARCINOMA; CANCER CELL CULTURE; CELL ASSAY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ARGININE; ATHEROSCLEROSIS; BIOLOGICAL TRANSPORT; CELL LINE; CHLOROQUINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRULLINE; DIPEPTIDES; ENDOTHELIUM, VASCULAR; GENES, REPORTER; HISTIDINE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LEUPEPTINS; LYSOSOMES; MEMBRANE TRANSPORT PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS;

EID: 80053280978     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.07.024     Document Type: Article

References (30)

1. Förstermann U., Münzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006, 113:1708-1714.
2. Hemmens B., Mayer B. Enzymology of nitric oxide synthases. Methods Mol Biol 1998, 100:1-32.
3. Fleming I. Molecular mechanisms underlying the activation of eNOS. Pflugers Arch 2010, 459:793-806.
4. Förstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 2008, 5:338-349.
5. Cooke J.P., Sydow K. A peculiar result and a fanciful hypothesis regarding l-arginine. Arterioscler Thromb Vasc Biol 2003, 23:1128. author reply - 9.
6. Böger R.H., Bode-Böger S.M. The clinical pharmacology of l-arginine. Annu Rev Pharmacol Toxicol 2001, 41:79-99.
7. Förstermann U., Closs E.I., Pollock J.S., Nakane M., Schwarz P., Gath I., et al. Nitric oxide synthase isoenzymes: characterization, molecular cloning and functions. Hypertension 1994, 23:1121-1131.
8. Simon A., Plies L., Habermeier A., Martine U., Reining M., Closs E.I. Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells. Circ Res 2003, 93:813-820.
9. Edgell C.J.S., McDonald C.C., Graham J.B. Permanent cell line expressing factor VIII related antigen established by hybridization. Proc Natl Acad Sci USA 1983, 80:3734-3737.
10. Forstermann U., Gorsky L.D., Pollock J.S., Ishii K., Schmidt H.H., Heller M., et al. Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin. Mol Pharmacol 1990, 38:7-13.
11. Marques C., Pereira P., Taylor A., Liang J.N., Reddy V.N., Szweda L.I., et al. Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J 2004, 18:1424-1426.
12. Hecker M., Sessa W.C., Harris H.J., Anggard E.E., Vane J.R. The metabolism of l-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle l-citrulline to l-arginine. Proc Natl Acad Sci USA 1990, 87:8612-8616.
13. Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Exp Biol Med (Marywood) 2006, 231:1197-1211.
14. Herrmann J., Lerman L.O., Lerman A. On to the road to degradation: atherosclerosis and the proteasome. Cardiovasc Res 2010, 85:291-302.
15. Thomas S., Kotamraju S., Zielonka J., Harder D., Kalyanaraman B. Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. Free Radic Biol Med 2007, 42:1049-1061.
16. Schnitzer J.E., Sung A., Horvat R., Bravo J. Preferential interaction of albumin-binding proteins, gp30 and gp18, with conformationally modified albumins. Presence in many cells and tissues with a possible role in catabolism. J Biol Chem 1992, 267:24544-24553.
17. Cooke J.P. ADMA: its role in vascular disease. Vasc Med 2005, 10(Suppl 1):S11-S17.
18. Pisoni R.L., Thoene J.G., Christensen H.N. Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal?. J Biol Chem 1985, 260:4791-4798.
19. Smith B.C., Denu J.M. Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta 2009, 1789:45-57.
20. Flam B.R., Hartmann P.J., Harrell-Booth M., Solomonson L.P., Eichler D.C. Caveolar localization of arginine regeneration enzymes, argininosuccinate synthase, and lyase, with endothelial nitric oxide synthase. Nitric Oxide 2001, 5:187-197.
21. Wilson A., Harada R., Nair N., Balasubramanian N., Cooke J. l-Arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 2007, 116:188-195.
22. Ananthakrishnan M., Barr F.E., Summar M.L., Smith H.A., Kaplowitz M., Cunningham G., et al. l-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol 2009, 297:L506-L511.
23. Schmidlin A., Fischer S., Wiesinger H. Transport of l-citrulline in neural cell cultures. Dev Neurosci 2000, 22:393-398.
24. Hecker M., Mitchell J., Swierkosz T., Sessa W., Vane J. Inhibition by l-glutamine of the release of endothelium-derived relaxation factor from cultured endothelial cells. Br J Pharmacol 1990, 101:237-239.
25. Swierkosz T., Mitchell J., Sessa W., Hecker M., Vane J. l-glutamine inhibits the release of endothelium derived relaxation factor from the rabbit aorta. Biochem Biophysiol Res Commun 1990, 172:143-148.
26. Wu G., Meininger C. Regulation of l-arginine synthesis from l-citrulline by l-glutamine in endothelial cells. Proc Natl Acad Sci USA 1993, 1993:H1965-H1971.
27. Herrera-Ruiz D., Wang Q., Gudmundsson O., Cook T., Smith R., Faria T., et al. Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissue. AAPS PharmSci 2001, 3(1):E9.
28. Yamashita T., Shimada S., Guo W., Satos K., Kohmura E., Hayakawa T., et al. Cloning and functional expression of a brain peptide/histidine transporter. J Biol Chem 1999, 272:10205-10211.
29. Sakata K., Yamashita T., Maeda M., Moriyama Y., Shimada S., Tohyama M. Cloning of a lymphatic peptide/histidine transporter. Biochem J 2001, 356:53-60.
30. Kikuta K., Sawamura T., Miwa S., Hashimoto N., Masaki T. High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine. Circ Res 1998, 83:1088-1096.