HIV Tat protein inhibits hERG K + channels: A potential mechanism of HIV infection induced LQTs

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 5, 2011, Pages 876-880

  Bai, Yun Long ^a   Liu, Hui Bin ^a   Sun, Bo ^a   Zhang, Ying ^a   Li, Qi ^a   Hu, Chao Wei ^a   Zhu, Jiu Xin ^a   Gong, Dong Mei ^a   Teng, Xue ^a   Zhang, Qin ^a   Yang, Bao Feng ^a   Dong, De Li ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

AIDS; HERG K + channel; HIV Tat protein; Long QT syndrome; Reactive oxygen species

Indexed keywords

MESSENGER RNA; POTASSIUM CHANNEL HERG; REACTIVE OXYGEN METABOLITE; TEMPOL; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL STRAIN HEK293; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; GUINEA PIG; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCUBATION TIME; INHIBITION KINETICS; LONG QT SYNDROME; NONHUMAN; OXIDATIVE STRESS; PATCH CLAMP; PATHOGENESIS; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; STABLE EXPRESSION; WESTERN BLOTTING; WHOLE CELL;

ACTION POTENTIALS; ANIMALS; ANTIOXIDANTS; CELL LINE; CYCLIC N-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; GENE EXPRESSION; GUINEA PIGS; HEK293 CELLS; HIV; HIV INFECTIONS; HUMANS; LONG QT SYNDROME; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPIN LABELS; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

CAVIA;

EID: 80053279080     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.07.017     Document Type: Article

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