B cell-activating factor controls the production of adipokines and induces insulin resistance

Obesity

Volumn 19, Issue 10, 2011, Pages 1915-1922

  Hamada, Maho ^a   Abe, Masanori ^a   Miyake, Teruki ^a   Kawasaki, Keitarou ^a   Tada, Fujimasa ^a   Furukawa, Shinya ^a   Matsuura, Bunzo ^a   Hiasa, Yoichi ^a   Onji, Morikazu ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; MESSENGER RNA; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; GENE EXPRESSION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MALE; METABOLIC SYNDROME X; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PARACRINE SIGNALING; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ADIPOCYTES; ADIPOKINES; ANIMALS; B-CELL ACTIVATING FACTOR; GENE EXPRESSION; GLUCOSE; INFLAMMATION; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MUS;

EID: 80053274395     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.165     Document Type: Article

References (25)

1. Ahima RS, Flier JS. Adipose tissue as an endocrine organ. Trends Endocrinol Metab 2000;11:327-332.
2. Tilg H, Moschen AR. Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008;14:222-231. (Pubitemid 351481853)
3. Kopp A, Buechler C, Neumeier M et al. Innate immunity and adipocyte function: ligand-specific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity (Silver Spring) 2009;17:648-656.
4. Moore PA, Belvedere O, Orr A et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-263. (Pubitemid 29330000)
5. Schneider P, MacKay F, Steiner V et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189: 1747-1756. (Pubitemid 29272691)
6. Litinskiy MB, Nardelli B, Hilbert DM et al. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nat Immunol 2002;3:822-829.
7. Nardelli B, Belvedere O, Roschke V et al. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 2001;97:198-204. (Pubitemid 32061261)
8. Thompson JS, Bixler SA, Qian F et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 2001;293:2108-2111. (Pubitemid 32848062)
9. Mackay F, Silveira PA, Brink R. B cells and the BAFF/APRIL axis: fast-forward on autoimmunity and signaling. Curr Opin Immunol 2007;19:327-336. (Pubitemid 46687013)
10. Kim YH, Choi BH, Cheon HG, Do MS. B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation. Exp Mol Med 2009;41:208-216.
11. Pelekanou V, Kampa M, Kafousi M et al. Expression of TNF-superfamily members BAFF and APRIL in breast cancer: immunohistochemical study in 52 invasive ductal breast carcinomas. BMC Cancer 2008;8:76.
12. Alexaki VI, Notas G, Pelekanou V et al. Adipocytes as immune cells: differential expression of TWEAK, BAFF, and APRIL and their receptors (Fn14, BAFF-R, TACI, and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 2009;183:5948-5956.
13. Miyake T, Akbar SM, Yoshida O et al. Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease. J Gastroenterol 2010;45:859-867.
14. Parry TJ, Riccobene TA, Strawn SJ et al. Pharmacokinetics and immunological effects of exogenously administered recombinant human B lymphocyte stimulator (BLyS) in mice. J Pharmacol Exp Ther 2001;296: 396-404. (Pubitemid 32112465)
15. Andrikopoulos S, Blair AR, Deluca N, Fam BC, Proietto J. Evaluating the glucose tolerance test in mice. Am J Physiol Endocrinol Metab 2008;295:E1323-E1332.
16. Claudio E, Brown K, Park S, Wang H, Siebenlist U. BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells. Nat Immunol 2002;3:958-965. (Pubitemid 35154010)
17. Yan M, Marsters SA, Grewal IS et al. Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity. Nat Immunol 2000;1: 37-41.
18. White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 2002;283:E413-E422. (Pubitemid 35230477)
19. Kim CS, Lee SC, Kim YM et al. Visceral fat accumulation induced by a high-fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity (Silver Spring) 2008;16:1261-1269. (Pubitemid 351770531)
20. Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 2003;278:45777-45784. (Pubitemid 37432722)
21. Tchoukalova YD, Koutsari C, Votruba SB et al. Sex-and depot-dependent differences in adipogenesis in normal-weight humans. Obesity (Silver Spring) 2010;18:1875-1880.
22. Yamauchi T, Kamon J, Waki H et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-946. (Pubitemid 32756432)
23. Flier JS. Diabetes. The missing link with obesity? Nature 2001;409:292-293.
24. Gao Z, Hwang D, Bataille F et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex. J Biol Chem 2002;277: 48115-48121. (Pubitemid 35470759)
25. Rui L, Aguirre V, Kim JK et al. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest 2001;107:181-189. (Pubitemid 32096834)