Myeloid related proteins activate Toll-like receptor 4 in human acute coronary syndromes

Atherosclerosis

Volumn 218, Issue 2, 2011, Pages 486-492

  Yonekawa, Keiko ^a   Neidhart, Michel ^a   Altwegg, Lukas A ^a   Wyss, Christophe A ^a   Corti, Roberto ^a   Vogl, Thomas ^c   Grigorian, Mariam ^d   Gay, Steffen ^a   Lüscher, Thomas F ^a,b   Maier, Willibald ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d Institute for Cancer Biology   (Denmark)

Author keywords

Acute coronary syndrome; Inflammation; Myeloid related protein; Toll like receptor

Indexed keywords

ANTIBODY; CD14 ANTIGEN; CD36 ANTIGEN; ENDOTOXIN; LIGAND; LIPOPOLYSACCHARIDE; MYELOID RELATED PROTEIN 14; MYELOID RELATED PROTEIN 8; POLYMYXIN B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CORONARY ARTERY THROMBOSIS; FEMALE; HUMAN; HUMAN CELL; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACUTE CORONARY SYNDROME; AGED; ANTIGENS, CD14; ATP-BINDING CASSETTE TRANSPORTERS; CALGRANULIN A; CALGRANULIN B; CYTOPLASM; ENDOTOXINS; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MONOCYTES; MYELOID CELLS; SEPSIS; SIGNAL TRANSDUCTION; THROMBOSIS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053270737     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.06.020     Document Type: Article

References (30)

1. Mayerl C., Lukasser M., Sedivy R., et al. Atherosclerosis research from past to present-on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow. Virchows Arch 2006, 449:96-103.
2. Methe H., Weis M. Atherogenesis and inflammation-was Virchow right?. Nephrol Dial Transplant 2007, 22:1823-1827.
3. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340:115-126.
4. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005, 352:1685-1695.
5. Piccinini A.M, Midwood K.S. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010, 2010.
6. Vainas T., Stassen F.R., Bruggeman C.A., et al. Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease. J Vasc Surg 2006, 44:326-332.
7. Krishnan J., Selvarajoo K., Tsuchiya M., Lee G., Choi S. Toll-like receptor signal transduction. Exp Mol Med 2007, 39:421-438.
8. Wyss C.A., Neidhart M., Altwegg L., et al. Cellular actors, Toll-like receptors, and local cytokine profile in acute coronary syndromes. Eur Heart J 2010, 31:1457-1469.
9. Ulevitch R.J. Therapeutics targeting the innate immune system. Nat Rev Immunol 2004, 4:512-520.
10. Foell D., Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 2004, 50:3762-3771.
11. Roth J., Burwinkel F., van den Bos C., et al. MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner. Blood 1993, 82:1875-1883.
12. Vogl T., Tenbrock K., Ludwig S., et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007, 13:1042-1049.
13. Altwegg L.A., Neidhart M., Hersberger M., et al. Myeloid-related protein 8/14 complex is released by monocytes and granulocytes at the site of coronary occlusion: a novel, early, and sensitive marker of acute coronary syndromes. Eur Heart J 2007, 28:941-948.
14. Ward J.R, Bingle L., Judge H.M., et al. Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. Thromb Haemost 2005, 94:831-838.
15. Chow J.C., Young D.W., Golenbock D.T., Christ W.J., Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999, 274:10689-10692.
16. Siegenthaler G., Roulin K., Chatellard-Gruaz D., et al. A heterocomplex formed by the calcium-binding proteins MRP8 (S100A8) and MRP14 (S100A9) binds unsaturated fatty acids with high affinity. J Biol Chem 1997, 272:9371-9377.
17. Liu S., Tobias R., McClure S., et al. Removal of endotoxin from recombinant protein preparations. Clin Biochem 1997, 30:455-463.
18. Wang R., Stephens J., Lacy M.J. Characterization of monoclonal antibody HTA125 with specificity for human TLR4. Hybrid Hybridomics 2003, 22:357-365.
19. Muta T., Takeshige K. Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations. Eur J Biochem 2001, 268:4580-4589.
20. Larrick J.W., Fischer D.G., Anderson S.J., Koren H.S. Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions. J Immunol 1980, 125:6-12.
21. Ospelt C., Brentano F., Rengel Y., et al. Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum 2008, 58:3684-3692.
22. Loser K., Vogl T., Voskort M., et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med 2010, 16:713-717.
23. Kerkhoff C., Sorg C., Tandon N.N., Nacken W. Interaction of S100A8/S100A9-arachidonic acid complexes with the scavenger receptor CD36 may facilitate fatty acid uptake by endothelial cells. Biochemistry 2001, 40:241-248.
24. Robinson M.J., Tessier P., Poulsom R., Hogg N. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 2002, 277:3658-3665.
25. Foell D., Wittkowski H., Vogl T., Roth J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 2007, 81:28-37.
26. Maier W., Altwegg L.A., Corti R., et al. Inflammatory markers at the site of ruptured plaque in acute myocardial infarction: locally increased interleukin-6 and serum amyloid a but decreased C-reactive protein. Circulation 2005, 111:1355-1361.
27. Healy A.M., Pickard M.D., Pradhan A.D., et al. Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 2006, 113:2278-2284.
28. Morrow D.A., Wang Y., Croce K., et al. Myeloid-related protein 8/14 and the risk of cardiovascular death or myocardial infarction after an acute coronary syndrome in the Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction (PROVE IT-TIMI 22) trial. Am Heart J 2008, 155:49-55.
29. Miyamoto S., Ueda M., Ikemoto M., et al. Increased serum levels and expression of S100A8/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable angina. Heart 2008, 94:1002-1007.
30. Ionita M.G., Vink A., Dijke I.E., et al. High levels of myeloid-related protein 14 in human atherosclerotic plaques correlate with the characteristics of rupture-prone lesions. Arterioscler Thromb Vasc Biol 2009, 29:1220-1227.