Functional polymorphism of the GTP cyclohydrolase 1 gene affects the personality trait of novelty seeking in healthy subjects

Neuroscience Letters

Volumn 503, Issue 3, 2011, Pages 220-223

  Sadahiro, Ryoichi ^a   Suzuki, Akihito ^a   Matsumoto, Yoshihiko ^a   Shibuya, Naoshi ^a   Enokido, Masanori ^a   Kamata, Mitsuhiro ^a   Goto, Kaoru ^a   Otani, Koichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

GCH1; Novelty seeking; Personality; Polymorphism

Indexed keywords

6 PYRUVOYLTETRAHYDROPTERIN SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NITRIC OXIDE SYNTHASE; PHENYLALANINE 4 MONOOXYGENASE; SEPIAPTERIN REDUCTASE; TRYPTOPHAN HYDROXYLASE; TYROSINE 3 MONOOXYGENASE;

ADULT; ARTICLE; BEHAVIOR; COOPERATION; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HARM REDUCTION; HUMAN; HUMAN EXPERIMENT; JAPANESE; MALE; NORMAL HUMAN; NOVELTY SEEKING BEHAVIOR; PERSONALITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REWARD; SELF TRANSCENDENCE;

ADULT; ALLELES; BLOOD PRESSURE; COOPERATIVE BEHAVIOR; EXONS; EXPLORATORY BEHAVIOR; FEMALE; GENOTYPE; GTP CYCLOHYDROLASE; HUMANS; MALE; PERSONALITY; PERSONALITY TESTS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; REAL-TIME POLYMERASE CHAIN REACTION; REWARD;

EID: 80053266867     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.08.040     Document Type: Article

References (22)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association, Washington, DC. 4th ed.
2. Antoniades C., Shirodaria C., Van Assche T., Cunnington C., Tegeder I., Lötsch J., Guzik T.J., Leeson P., Diesch J., Tousoulis D., Stefanadis C., Costigan M., Woolf C.J., Alp N.J., Channon K.M. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. J. Am. Coll. Cardiol. 2008, 52:158-165.
3. Audrain-McGovern J., Rodriguez D., Patel V., Faith M.S., Rodgers K., Cuevas J. How do psychological factors influence adolescent smoking progression? The evidence for indirect effects through tobacco advertising receptivity. Pediatrics 2006, 117:1216-1225.
4. Cloninger C.R., Przybeck T.R., Svrakic D.M., Wetzel R.D. The Temperament and Character Inventory (TCI): A Guide to its Development and Use 1994, Center for Psychobiology of Personality, Washington University, St Louis, MI.
5. Cloninger C.R., Svrakic D.M., Przybeck T.R. Can personality assessment predict future depression? A twelve-month follow-up of 631 subjects. J. Affect. Disord. 2006, 92:35-44.
6. Cooper J.R., Bloom F.E., Roth R.H. The Biochemical Basis of Neurophamacology 2003, Oxford University Press, Oxford. 8th ed.
7. Costa P.T., McCrae R.R. The NEO-PI/NEO-FFI manual supplement, Odessa. Psychol. Assess. Resour. 1989.
8. Doehring A., Antoniades C., Channon K.M., Tegeder I., Lotsch J. Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk. Mutat. Res. 2008, 659:195-201.
9. Farmer R.F., Seeley J.R. Temperament and character predictors of depressed mood over a 4-year interval. Depress. Anxiety 2009, 26:371-381.
10. Gordon N. Segawa's disease: dopa-responsive dystonia. Int. J. Clin. Pract. 2008, 62:943-946.
11. Hyland K., Gunasekara R.S., Munk-Martin T.L., Arnold L.A., Engle T. The hph-1 mouse: a model for dominantly inherited GTP-cyclohydrolase deficiency. Ann. Neurol. 2003, 54(suppl 6):46-48.
12. Kijima N., Saito R., Suzuki M., Yoshino A., Ono Y., Kato M., Kitamura T. Cloninger's seven factor model of temperament and character and Japanese version of Temperament and Character Inventory (TCI). Jpn. J. Psychiatr. Diagn. 1996, 7:379-399. (Japanese).
13. Lam A.A., Hyland K., Heales S.J. Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states. J. Inherit. Metab. Dis. 2007, 30:256-262.
14. Liao Y.F., Zeng T.S., Chen L.L., Li Y.M., Yu F., Hu L.J., Yue L. Association of a functional polymorphism (C59038T) in GTP cyclohydrolase 1 gene and type 2 diabetic macrovascular disease in the Chinese population. J. Diabetes Complications 2010, 24:313-319.
15. Reif A., Kiive E., Kurrikoff T., Paaver M., Herterich S., Konstabel K., Tulviste T., Lesch K.P., Harro J. A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity. Psychopharmacology 2011, 214:239-248.
16. Sadahiro R., Suzuki A., Shibuya N., Kamata M., Matsumoto Y., Goto K., Otani K. Association study between a functional polymorphism of tyrosine hydroxylase gene promoter and personality traits in healthy subjects. Behav. Brain Res. 2010, 17:209-212.
17. Serova L.I., Filipenko M., Schilt N., Veerasirikul M., Sabban E.L. Estrogen-triggered activation of GTP cyclohydrolase 1 gene expression: role of estrogen receptor subtypes and interaction with cyclic AMP. Neuroscience 2006, 140:1253-1263.
18. Shimoji M., Hirayama K., Hyland K., Kapatos G. GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice. J. Neurochem. 1999, 72:757-764.
19. Shiraishi H., Suzuki A., Fukasawa T., Aoshima T., Ujiie Y., Ishii G., Otani K. Monoamine oxidase A gene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants. Psychiatr. Genet. 2006, 16:55-58.
20. Tegeder I., Costigan M., Griffin R.S., Abele A., Belfer I., Schmidt H., Ehnert C., Nejim J., Marian C., Scholz J., Wu T., Allchorne A., Diatchenko L., Binshtok A.M., Goldman D., Adolph J., Sama S., Atlas S.J., Carlezon W.A., Parsegian A., Lötsch J., Fillingim R.B., Maixner W., Geisslinger G., Max M.B., Woolf C.J. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat. Med. 2006, 12:1269-1277.
21. Wegener G., Volke V., Rosenberg R. Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo. Br. J. Pharmacol. 2000, 130:575-580.
22. Zhang L., Rao F., Zhang K., Khandrika S., Das M., Vaingankar S.M., Bao X., Rana B.K., Smith D.W., Wessel J., Salem R.M., Rodriguez-Flores J.L., Mahata S.K., Schork N.J., Ziegler M.G., O'Connor D.T. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. J. Clin. Invest. 2007, 117:2658-2671.