Genetic variation in ABCA1 and risk of cardiovascular disease

Atherosclerosis

Volumn 218, Issue 2, 2011, Pages 281-282

  Frikke Schmidt, Ruth ^a  

^a Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL TRANSPORT; CORONARY ARTERY DISEASE; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MORTALITY; NOTE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROTEIN EXPRESSION; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; DISEASE ASSOCIATION; GENETIC VARIATION; HEREDITY; NONHUMAN; PATIENT IDENTIFICATION;

ALLELES; ATP-BINDING CASSETTE TRANSPORTERS; CARDIOVASCULAR DISEASES; COHORT STUDIES; GENETIC MARKERS; GENETIC VARIATION; HOMOZYGOTE; HUMANS; MALE; MUTATION; RISK;

EID: 80053228782     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.04.010     Document Type: Note

References (21)

1. The Emerging Risk Factors Collaboration Major lipids, apolipoproteins, and risk of vascular disease. JAMA 2009, 302:1993-2000.
2. Tall A.R., Breslow J.L., Rubin E.M. Genetic disorders affecting plasma high-density lipoproteins. The metabolic and molecular bases of inherited disease 2001, 2915-2936. McGraw-Hill, New York. 8th ed. C.R. Scriver, A.L. Beaudet, D. Valle, W.S. Sly (Eds.).
3. Frikke-Schmidt R., Nordestgaard B.G., Stene M.C.A., et al. Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA 2008, 299:2524-2532.
4. Teslovich T.M., Musunuru K., Smith A.V., et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010, 466:707-713.
5. Johannsen T.H., Kamstrup P.R., Andersen R.V., et al. Hepatic lipase, genetically elevated high-density lipoprotein, and risk of ischemic cardiovascular disease. J Clin Endocrinol Metab 2009, 94:1264-1273.
6. Willer C.J., Sanna S., Jackson A.U., et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008, 40:161-169.
7. Nordestgaard B.G., Tybjærg-Hansen A. Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk. Curr Opin Lipidol 2011, 22:113-122.
8. Frikke-Schmidt R., Nordestgaard B.G., Schnohr P., Steffensen R., Tybjaerg-Hansen A. Mutation in ABCA1 predicted risk of ischemic heart disease in the Copenhagen City Heart Study Population. J Am Coll Cardiol 2005, 46:1516-1520.
9. Frikke-Schmidt R., Nordestgaard B.G., Jensen G.B., Steffensen R., Tybjærg-Hansen A. Genetic variation in ABCA1 predicts ischemic heart disease in the general population. Arterioscler Thromb Vasc Biol 2008, 28:180-186.
10. Zwarts K.Y., Clee S.M., Zwinderman A.H., et al. ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels. Clin Genet 2002, 61:115-125.
11. Jensen M.K., Pai J.K., Mukamal K.J., Overvad K., Rimm E.B. Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease. Atherosclerosis 2007, 195:e172-e180.
12. Regieli JJ, Doevendans PA, Grobbee DE, Zwinderman AH, van der Graaf Y, Kastelein JJP, Jukema JW. ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting. Atherosclerosis, Submitted.
13. Timmins J.M., Lee J.Y., Boudyguina E., et al. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 2005, 115:1333-1342.
14. Brunham L.R., Kruit J.K., Iqbal J., et al. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 2006, 116:1052-1062.
15. Hamon Y., Broccardo C., Chambenoit O., et al. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2000, 2:399-406.
16. Luciani M.F., Chimini G. The ATP binding cassette transporter ABC1, is required for engulfment of corpses generated by apoptotic cell death. EMBO J 1996, 15:226-235.
17. Bodmer W., Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 2008, 40:695-701.
18. Humphries S.E., Cooper J.A., Talmud P.J., Miller G.J. Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. Clin Chem 2007, 53:8-16.
19. Dyson G., Frikke-Schmidt R., Nordestgaard B.G., Tybjaerg-Hansen A., Sing C.F. Modifications to the patient rule-induction method that utilize non-additive combinations of genetic and environmental effects to define partitions that predict ischemic heart disease. Genet Epidemiol 2009, 33:317-324.
20. Kathiresan S., Melander O., Anevski D., et al. Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 2008, 358:1240-1249.
21. Stengård J.H., Dyson G., Frikke-Schmidt R., Tybjærg-Hansen A., Nordestgaard B.G., Sing C.F. Context-dependent associations between variation in risk of ischemic heart disease and variation in the 5' promoter region of the apolipoprotein E gene in Danish women. Circ Cardiovasc Genet 2010, 3:22-30.