Synthesis, fluorescence and biodistribution of a bone-targeted near-infrared conjugate

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 5175-5183

  Mizrahi, Dana M ^a,b   Ziv Polat, Ofra ^a   Perlstein, Benny ^a   Gluz, Eran ^a   Margel, Shlomo ^a  

^a BAR ILAN UNIVERSITY   (Israel)

^b ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Bioconjugation; Biodistribution; Bone imaging; Bone disease; Fluorescence; Indocyanine green; Near infrared dye; Total synthesis

Indexed keywords

ALENDRONIC ACID; CARBOXYLIC ACID; INDOCYANINE GREEN; PAMIDRONIC ACID; RISEDRONIC ACID; SODIUM 4 [2 [(1,3,5,7) 7 [3 [5 (4 HYDROXY 4,4 DIPHOSPHONOBUTYLAMINO) 5 OXOPENTYL] 1,1 DIMETHYL 1H BENZO[E]INDOL 2 (3H) YLIDENE]HEPTA 1,3,5 TRIENYL] 1,1 DIMETHYL 1H BENZO[E]INDOLIUM 3 YL]BUTANE 1 SULFONATE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DISEASE; BONE SCINTISCANNING; CONTROLLED STUDY; COVALENT BOND; DRUG BINDING; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; FLUORESCENCE ANALYSIS; GAMMA RADIATION; IN VIVO STUDY; MALE; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; OSTEOPOROSIS; PAGET BONE DISEASE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BONE AND BONES; FLUORESCENT DYES; INDOCYANINE GREEN; MALE; MICE; MICE, INBRED BALB C; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, NEAR-INFRARED; TISSUE DISTRIBUTION;

EID: 80053215114     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.08.040     Document Type: Article

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