Long-term α 1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity

Molecular Pharmacology

Volumn 80, Issue 4, 2011, Pages 747-758

  Doze, Van A ^a   Papay, Robert S ^b   Goldenstein, Brianna L ^a   Gupta, Manveen K ^b   Collette, Katie M ^a   Nelson, Brian W ^a   Lyons, Mariaha J ^a   Davis, Bethany A ^a   Luger, Elizabeth J ^a   Wood, Sarah G ^a   Haselton, James R ^a   Simpson, Paul C ^c,d   Perez, Dianne M ^b  

^a UNIVERSITY OF NORTH DAKOTA   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; CIRAZOLINE;

AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN SLICE; COGNITION; FEMALE; HIPPOCAMPUS; LEARNING; LOCOMOTION; LONG TERM POTENTIATION; LONGEVITY; MALE; MEMORY; MOOD; MOUSE; MUTANT; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYNAPTIC TRANSMISSION;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; AFFECT; ANIMALS; COGNITION; FEMALE; HIPPOCAMPUS; LONG-TERM POTENTIATION; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURONAL PLASTICITY; ORGAN CULTURE TECHNIQUES; RECEPTORS, ADRENERGIC, ALPHA-1; SYNAPSES;

EID: 80053214400     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.073734     Document Type: Article

References (41)

1. 1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol Psychiatry 9:278-286.
2. 1-noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biol Psychiatry 45:26-31.
3. Bach ME, Barad M, Son H, Zhuo M, Lu YF, Shih R, Mansuy I, Hawkins RD, and Kandel ER (1999) Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci USA 96:5280-5285. (Pubitemid 29214574)
4. 1A/1L-adrenoceptor partial agonist: a potential therapy for stress urinary incontinence. BJU Int 93:162-170.
5. Bullido MJ, Ramos MC, Ruiz-Gómez A, Tutor AS, Sastre I, Frank A, Coria F, Gil P, Mayor F Jr, and Valdivieso F (2004) Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's. Neurobiol Aging 25:853-859. (Pubitemid 38813165)
6. 1-adrenoceptor agonist cirazoline. Eur J Pharmacol 210:11-16.
7. De Montigny C, Silverstone PH, Debonnel G, Blier P, and Bakish D (1999) Venlafaxine in treatment-resistant major depression: a Canadian multicenter, openlabel trial. J Clin Psychopharmacol 19:401-406. (Pubitemid 29451504)
8. Deng W, Aimone JB, and Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11:339-350.
9. 1B- adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. Brain Res 1285:148-157.
10. 1- adrenoceptors inhibits memory consolidation in the chick. Eur J Neurosci 14:1369-1376.
11. 1 adrenergic receptor regulation of seizures and neurodegeneration (Abstract). FASEB J 22:748.12.
12. 1-adrenoceptor stimulation functionally antagonizes the hypnotic response to dexmedetomidine, an alpha 2-adrenoceptor agonist. Anesthesiology 75:252-256.
13. 1A adrenergic receptors regulate neurogenesis and gliogenesis. Mol Pharmacol 76:314-326.
14. Hollander E, Friedberg J, Wasserman S, Allen A, Birnbaum M, and Koran LM (2003) Venlafaxine in treatment-resistant obsessive-compulsive disorder. J Clin Psychiatry 64:546-550. (Pubitemid 36618283)
15. 1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation 115:763-772.
16. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
17. Jensen BC, O'Connell TD, and Simpson PC (2011) Alpha-1adrenergic receptors: Targets for agonist drugs to treat heart failure. J Mol Cell Cardiol doi:10.1016/ j.yjmcc.2010.11.014.
18. Klingner M, Apelt J, Kumar A, Sorger D, Sabri O, Steinbach J, Scheunemann M, and Schliebs R (2003) Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology. Int J Dev Neurosci 21:357-369. (Pubitemid 37346400)
19. Landfield PW and Lynch G (1977) Impaired monosynaptic potentiation in in vitro hippocampal slices from aged, memory-deficient rats. J Gerontol 32:523-533. (Pubitemid 8180446)
20. Larson EB, Shadlen MF, Wang L, McCormick WC, Bowen JD, Teri L, and Kukull WA (2004) Survival after initial diagnosis of Alzheimer disease. Ann Intern Med 140:501-509.
21. Libert S, Cohen D, and Guarente L (2008) Neurogenesis directed by Sirt1. Nat Cell Biol 10:373-374.
22. 1-adrenergic, dopamine and serotonin systems. J Neural Transm 106:197-211.
23. Malberg JE, Eisch AJ, Nestler EJ, and Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104-9110. (Pubitemid 32042912)
24. 1-adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biol Psychiatry 46:1259-1265.
25. 1-adrenergic receptor subtypes. Mol Pharmacol 46: 929-936.
26. Nakadate K, Matsukawa M, and Okado N (2006) Identification of adrenoceptor subtype-mediated changes in the density of synapses in the rat visual cortex. Neuroscience 138:37-46. (Pubitemid 43222067)
27. Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, and Ohta S (2008) Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci 28: 6239-6249.
28. 1AAR is expressed in neurons, GABAergic interneurons, and NG2 oligodendrocyte progenitors. J Comp Neurol 497:209-222.
29. 1 agonist or a partial agonist at the glycine site of the NMDA receptor. Neurobiol Learn Mem 67:69-74.
30. 1-adrenergic receptors facilitates spatial learning in rats. Eur Neuropsychopharmacol 8:17-26.
31. 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci USA 99:9474-9479.
32. 1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism. Cardiovasc Res 65:436-445.
33. Ruffolo RR Jr and Waddell JE (1982) Receptor interactions of imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist. J Pharmacol Exp Ther 222:29-36.
34. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809. (Pubitemid 36962615)
35. Schmidt-Hieber C, Jonas P, and Bischofberger J (2004) Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature 429:184-187. (Pubitemid 38656194)
36. 1- adrenoceptors: their role in the modulation of attention and memory formation. Pharmacol Ther 83:49-65.
37. Snyder JS, Kee N, and Wojtowicz JM (2001) Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. J Neurophysiol 85:2423-2431. (Pubitemid 32525520)
38. Sugimoto Y, Tagawa N, Kobayashi Y, Hotta Y, and Yamada J (2007) Effects of the serotonin and noradrenaline reuptake inhibitor (SNRI) milnacipran on marble burying behavior in mice. Biol Pharm Bull 30:2399-2401. (Pubitemid 350223737)
39. Szot P, White SS, Greenup JL, Leverenz JB, Peskind ER, and Raskind MA (2007) Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Neuroscience 146:471-480. (Pubitemid 46654630)
40. Yan XB, Hou HL, Wu LM, Liu J, and Zhou JN (2007) Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia. Neuropharmacology 53: 487-495. (Pubitemid 47284182)
41. Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, Bogue MA, Mills KD, Peters LL, Bult CJ, et al. (2009) Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 8:277-287.