Esophageal stem cells and 3D-cell culture models

Annals of the New York Academy of Sciences

Volumn 1232, Issue 1, 2011, Pages 316-322

  Souza, Rhonda F ^a   Schwartz, Robert E ^b,c   Mashimo, Hiroshi ^c,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d VA BOSTON HEALTHCARE SYSTEM   (United States)

Author keywords

3D cell culture models; Acid reflux; Barrett's esophagus; Bile reflux; Metaplasia; Neoplastic progression; Stem cells; Transdifferentiation

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; BARRETT ESOPHAGUS; BIOLOGICAL MODEL; BONE MARROW CELL; CELL CULTURE; CELL FUNCTION; CELL TRANSDIFFERENTIATION; DISEASE COURSE; DYSPLASIA; ESOPHAGUS; HUMAN; IN VITRO STUDY; INTESTINE; METAPLASIA; NONHUMAN; PHENOTYPE; STEM CELL;

EID: 80053213043     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.06070.x     Document Type: Article

References (14)

1. Sarosi, G., G. Brown, K. Jaiswal, et al 2008. Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus. Dis. Esophagus 21: 43-50.
2. Hutchinson, L., B. Stenstrom, D. Chen, et al 2010. Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell. Transplant. Stem. Cell Dev.
3. Milano, F., J.W. Van Baal, Ns. Buttar, et al 2007. Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cell. Gastroenterology 132: 2412-2421.
4. Wang, D.H., N.J. Clemons, T. Miyashita, et al 2010. Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology 138: 1810-1822.
5. Wang, D.H., & R.F. Souza 2011. Biology of Barrett's esophagus and esophageal adenocarcinoma. Gastrointest. Endosc. Clin. N. Am. 21: 25-38.
6. Kong, J., H. Nakagawa, B.K. Isariyawongse, et al 2009. Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis 30: 122-130.
7. Palanca-Wessels, M.C., M.T. Barrett, P.C. Galipeau, et.al. 1998. Geneticanalysis of Barrett's esophagus Epithelial cultures exhibiting cytogenetic and ploidy abnormalities. Gastroenterology 114: 295-304.
8. Okawa, T., C.Z. Michaylira, J. Kalabis, et al 2007. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev. 21: 2788-2803.
9. Grugan, K.D., C.G. Miller, Y. Yao, et.al. 2010. Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion. Proc. Natl. Acad. Sci. USA 107: 11026-11031.
10. Sato, T., R.G. Vries, H.J. Snippert, et al 2009. Single Lgr5 stem cells build crypt-villus structuresin vitrowithout a mesenchymal niche. Nature 459: 262-265.
11. Becker L., Q. Huang, & H. Mashimo 2008. Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal Tissue. Sci. World J. 8: 1168-1176.
12. Becker, L., Q. Huang & H. Mashimo 2009. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. Dis. Esophagus 23: 168-174.
13. Zhang, X., Q. Huang, R.K. Goyal & R.D. Odze 2008. DNA Ploidy abnormalities in basal and superficial regions of the crypts in Barrett's esophagus and associated neoplastic lesions. Am. J. Surg. Pathol. 32: 1327-1335.
14. Takubo, K., J.M. Nixon & J.R. Jass 1995. Ducts of esophageal glands proper and paneth cells in Barrett's esophagus: frequency in biopsy specimens. Pathology 27: 315-317.