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Volumn 46, Issue 10, 2011, Pages 4915-4923

Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-β-agarofuran sesquiterpenes

(6) Perestelo, Nayra R a Sánchez Cañete, María P b Gamarro, Francisco b Jiménez, Ignacio A a Castanys, Santiago b Bazzocchi, Isabel L a,b

a UNIVERSIDAD DE LA LAGUNA (Spain)

b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA (Spain)

Author keywords

Celastraceae; Dihydro agarofuran sesquiterpenes; Human MDR1 P glycoprotein inhibitors; Maytenus jelskii; Structure activity relationship

Indexed keywords

1 ACETOXY 2,6 DIBENZOYLOXY 9 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 1,15 DIACETOXY 2,6 DIBENZOYLOXY 9 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 1,15 DIACETOXY 6 BENZOYLOXY 9 (3 FUROYLOXY) 2,4 DIHYDROXY DIHYDRO BETA AGAROFURAN; 1,15 DIACETOXY 6,9 DIBENZOYLOXY 2,4 HYDROXY DIHYDRO BETA AGAROFURAN; 1,2,15 TRIACETOXY 6 BENZOYLOXY 9 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 1,2,6,15 TETRAACETOXY 9 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 2 ACETOXY 1,9 BIS(3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 2 ACETOXY 9 BENZOYLOXY 1 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 2 ACETOXY 9 BENZOYLOXY 1 (3 FUROYLOXY)DIHYDRO BETA AGAROFURAN; 2 ACETOXY 9 TRANS CYNAMOILOXY 1 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 2,3 DIACETOXY 9 BENZOYLOXY 1 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; 2,3 DIACETOXY 9 BENZOYLOXY 1 (3 FUROYLOXY)DIHYDRO BETA AGAROFURAN; 9 BENZOYLOXY 1 (3 FUROYLOXY) 4 HYDROXY DIHYDRO BETA AGAROFURAN; AGAROFURAN DERIVATIVE; DAUNORUBICIN; GLYCOPROTEIN P INHIBITOR; HERBACEOUS AGENT; MULTIDRUG RESISTANCE PROTEIN 1; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE;

ARTICLE; BENZYLATION; CELL STRAIN 3T3; CHEMOSENSITIVITY; CHEMOSENSITIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACETYLATION; DRUG ISOLATION; DRUG MECHANISM; DRUG SYNTHESIS; ESTERIFICATION; HUMAN; HUMAN CELL; IC 50; LIQUID CHROMATOGRAPHY; MAMMAL CELL; MAYTENUS; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; DRUG RESISTANCE, MULTIPLE; FRUIT; HUMANS; MAYTENUS; MODELS, MOLECULAR; P-GLYCOPROTEIN; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; UP-REGULATION;

EID: 80053212367 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.07.048 Document Type: Article

Times cited : (19)

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